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Secretory non-pancreatic (group II) phospholipase A 2 (sPLA 2 ) releases precursors of important mediators of inflammation from phospholipids. Based on the inflammatory character of atherosclerosis we previously described the identification of sPLA 2 in human atherosclerotic plaques. In vitro studies on lipoproteins have shown that sPLA 2 is able to favour the formation...
Atherosclerotic plaques exhibit a series of features that are similar to those of chronic inflammation. Based on the fact that during inflammation several cell types synthesize and secrete a group II phospholipase A2 (PLA2), an immunohistochemical study was undertaken to explore whether this enzyme can be identified in human atherosclerotic lesions. Tissue specimens obtained from 13 patients who...
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