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Lefty is a novel member of the transforming growth factor (TGF) supergene family which has the potential to antagonise actions of TGF-β1 – the main factor driving fibrotic disease in the kidney and in other organs. TGF-β1 can induce fibrosis through several mechanisms, including epithelial–mesenchymal transition (EMT) which contributes to myofibroblast accumulation in the renal interstitium. This...