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A new hypothesis regarding the effect of vitamin K 3 On hepatoma cell growth is presented. In brief, exploration of cell growth activity has been identified with the action of p34 cdc2 kinase and its associated protein tyrosine phosphatase. After exploring a series of substituted derivatives of vitamin K and vitamin K 3 oxide, we suggest a mechanism involving...
The syntheses of four trifunctional reagents for alkylating sulfhydryl groups in proteins are described: N-γ-maleimidobutyrylbiocytinyl-tyramine (compound I) and its sulfone, N-γ-maleimidobutyrylbiocytinyltyrosine (compound II), and N-α-4-maleimidobutyrylbiocytinamido-2 '-[p-(hydroxyphenyl)-propionamido] ethane (compound III). Each reagent contains a maleimide function capable of reacting with SH...
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