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Recent studies identified bone morphogenic protein 6 (BMP6) as a key regulator of hepatic hepcidin expression and iron metabolism, but the cellular source of BMP6 and the reason for its specific effect on hepatocytes are unknown.BMP and hepcidin expression upon iron sensing were analyzed in vivo in BMP6 −/− and BMP6 +/+ mice and ex vivo in tissue and in vitro in cells of the liver...