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Zebrafish have proven to be a crucial model for biological elucidations, especially heart-disease studies, owing to their remarkable regeneration capacity. Other than conventional methods, monitoring of electrocardiogram (ECG) has shown promising results recently; however, experiments were usually carried out with sedated fish, resulting in affected signals. In this work, wireless power transfer (WPT)...
Genome sequencing projects have revealed thousands of suspected genes, challenging researchers to develop efficient large-scale functional analysis methodologies. Determining the function of a gene product generally requires a means to alter its function. Genetically tractable model organisms have been widely exploited for the isolation and characterization of activating and inactivating mutations...
Discovering target and off-target effects of specific compounds is critical to drug discovery and development. We generated a compendium of “chemical-genetic interaction” profiles by testing the collection of viable yeast haploid deletion mutants for hypersensitivity to 82 compounds and natural product extracts. To cluster compounds with a similar mode-of-action and to reveal insights into the cellular...
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