Search results for: Junpei Soeda

Items from 1 to 20 out of 24 results

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Acetylcholine induces fibrogenic effects via M2/M3 acetylcholine receptors in non‐alcoholic steatohepatitis and in primary human hepatic stellate cells

Maelle L Morgan, Barbara Sigala, Junpei Soeda, Paul Cordero, more

Journal of Gastroenterology and Hepatology > 31 > 2 > 475 - 483

BackgroundThe parasympathetic nervous system (PNS), via neurotransmitter acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear. AimsWe aimed to determine the fibrogenic responses of human hepatic stellate cells (hHSC) to ACh and the relevance of the PNS in hepatic fibrosis in patients with non‐alcoholic steatohepatitis (NASH)...

article

Immunomodulatory and antioxidant function of albumin stabilises the endothelium and improves survival in a rodent model of chronic liver failure

Rita Garcia-Martinez, Fausto Andreola, Gautam Mehta, Katie Poulton, more

Journal of Hepatology > 2015 > 62 > 4 > 799-806

Liver failure is characterized by endothelial dysfunction, which results in hemodynamic disturbances leading to renal failure. Albumin infusion improves hemodynamics and prevents renal dysfunction in advance liver failure. These effects are only partly explained by the oncotic properties of albumin. This study was designed to test the hypothesis that albumin exerts its beneficial effects by stabilising...

article

The beta‐adrenoceptor agonist isoproterenol rescues acetaminophen‐injured livers through increasing progenitor numbers by Wnt in mice

Junpei Soeda, Angelina Mouralidarane, Shuvra Ray, Marco Novelli, more

Hepatology > 60 > 3 > 1023 - 1034

Acetaminophen (APAP)‐induced acute liver injury (AILI) is a major health problem. Accumulating evidence suggests that the sympathetic nervous system (SNS) regulates neuronal and hematopoietic progenitors. SNS signaling affects hepatic progenitor/oval cells (HPCs) and β‐adrenoceptor agonism will expand HPCs to reduce AILI. Dopamine β‐hydroxylase‐deficient mice (Dbh^−/−), lacking catecholamine SNS neurotransmitters,...

article

Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis

Chad McKee, Junpei Soeda, Esra Asilmaz, Barbara Sigalla, more

Biochemical and Biophysical Research Communications > 2013 > 437 > 4 > 597-602

Prazosin an α1-adrenoceptor (AR) antagonist has been shown to reduce liver injury in a mouse model of non-alcoholic steatohepatitis (NASH) and is suggested as a potential treatment of NASH especially given its concomitant anti-fibrotic properties. The effect however, of β-AR blockade in non-cirrhotic NASH is unknown and is as such investigated here. In the presence of the β-blocker propranolol (PRL),...

article

Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice

Angelina Mouralidarane, Junpei Soeda, Clara Visconti‐Pugmire, Anne‐Maj Samuelsson, more

Hepatology > 58 > 1 > 128 - 138

The global prevalence of obesity‐induced liver disease (nonalcoholic fatty liver disease; NAFLD) is rising. Suggested causes include a role for in utero influences of maternal obesity compounded by the availability of energy‐dense foods throughout postnatal life. Using a physiologically relevant model, we investigated the role of the innate immune system in liver injury induced by maternal obesity...

article

Developmental programming in the pathogenesis of non-alcoholic fatty pancreas disease in mice

Carter Rebeca, Angelina Mouralidarane, Junpei Soeda, Ray Shruva, more

Pancreatology > 2013 > 13 > 1 > e7-e8

article

Protein Engineered Variants of Hepatocyte Growth Factor/Scatter Factor Promote Proliferation of Primary Human Hepatocytes and in Rodent Liver

Jacob Ross, Ermanno Gherardi, Noemi Mallorqui–Fernandez, Marco Bocci, more

Gastroenterology > 2012 > 142 > 4 > 897-906

Hepatocyte growth factor/scatter factor (HGF/SF) stimulates hepatocyte DNA synthesis and protects against apoptosis; in vivo it promotes liver regeneration and reduces fibrosis. However, its therapeutic value is limited by its complex domain structure, high cost of production, instability, and poor tissue penetration due to sequestration by heparin sulfate proteoglycans (HSPGs). Using protein engineering...

article

Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells

Junpei Soeda, Maelle Morgan, Chad McKee, Angelina Mouralidarane, more

Biochemical and Biophysical Research Communications > 2012 > 417 > 1 > 17-22

Cigarette smoke (CS) may cause liver fibrosis but possible involved mechanisms are unclear. Among the many chemicals in CS is nicotine – which affects cells through nicotinic acetylcholine receptors (nAChR). We studied the effects of nicotine, and involved pathways, on human primary hepatic stellate cells (hHSCs), the principal fibrogenic cells in the liver. We then determined possible disease relevance...

article

Pathophysiology and clinical management of non-alcoholic fatty liver disease

Angelina Mouralidarane, Jude A. Oben, Junpei Soeda

Medicine > 2011 > 39 > 10 > 592-596

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction in the Western world. It defines the spectrum from steatosis to cirrhosis and hepatocellular carcinoma. The predominant cause of NAFLD is obesity. Its pathogenesis involves insulin resistance, hepatic fat deposition, consequent increased oxidant stress, activation of matrix producing cells and propagation of fibrogenesis...

article

Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells

Hiroshi Sakai, Yoh-ichi Tagawa, Miho Tamai, Hiroaki Motoyama, more

Biochemical and Biophysical Research Communications > 2010 > 403 > 3-4 > 298-304

Hepatic stem/progenitor cells are one of several cell sources that show promise for restoration of liver mass and function. Although hepatic progenitor cells (HPCs), including oval cells, are induced by administration of certain hepatotoxins in experimental animals, such a strategy would be inappropriate in a clinical setting. Here, we investigated the possibility of isolating HPCs in a portal branch-ligated...

article

Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice

Jude A. Oben, Angelina Mouralidarane, Anne-Maj Samuelsson, Phillippa J. Matthews, more

Journal of Hepatology > 2010 > 52 > 6 > 913-920

Obesity induced, non-alcoholic fatty liver disease (NAFLD), is now the major cause in affluent countries, of the spectrum of steatosis-to-cirrhosis. Obesity and NAFLD rates in reproductive age women, and adolescents, are rising worldwide. Our hypothesis was that maternal obesity and lactation transmit to the offspring a pre-disposition to dysmetabolism, obesity and NAFLD.Female mice were fed standard...

article

Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease

Jude A. Oben, Trusha Patel, Angelina Mouralidarane, Ann Maj Samuelsson, more

Biochemical and Biophysical Research Communications > 2010 > 394 > 1 > 24-28

The prevalence of pancreatic adenocarcinoma (PAC) parallels rising rates of obesity and dysmetabolism, a possible link being non-alcoholic fatty pancreas disease (NAFPD). We have recently shown that maternal obesity programmes the development of a dysmetabolic and fatty liver (non-alcoholic fatty liver disease, NAFLD) phenotype in adult offspring. Since the pancreas and liver originate from the same...

article

Clinical and pathological features of primary carcinoma of the cystic duct

Takenari Nakata, Akira Kobayashi, Shiro Miwa, Junpei Soeda, more

Journal of Hepato-Biliary-Pancreatic Sciences > 2009 > 16 > 1 > 75-82

Background According to Farrar’s criteria, a tumor restricted to the cystic duct is defined as cystic duct carcinoma, but this definition excludes advanced carcinoma originating from the cystic duct. Patients and methods For the purpose of this study, primary cystic duct carcinoma was defined as a tumor originating from the cystic duct. We investigated the clinicopathological features of 15 cystic...

article

Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer

Terumasa Noike, Shiro Miwa, Junpei Soeda, Akira Kobayashi, more

Human Pathology > 2008 > 39 > 2 > 201-208

We examined whether the expression of thioredoxin-1 (Trx-1) was associated with patient prognosis after liver resection for metastatic colorectal cancer. Eighty-four patients underwent resection of liver metastases from colorectal cancer, leaving no macroscopic evidence of residual tumor. Immunohistochemical study was performed to evaluate the relation among Trx-1, vascular endothelial growth factor...

article

Is major hepatectomy with pancreatoduodenectomy justified for advanced biliary malignancy?

Shiro Miwa, Akira Kobayashi, Yasuhiko Akahane, Takenari Nakata, more

Journal of Hepato-Biliary-Pancreatic Sciences > 2007 > 14 > 2 > 136-141

Background/Purpose Major hepatectomy with concomitant pancreatoduodenectomy (M-HPD) is usually indicated for the resection of diffuse bile duct cancer or advanced gallbladder cancer. This is the only procedure that can potentially cure such advanced cancers, so both a low mortality rate and long-term survival could potentially justify performing this procedure. Methods Between 1990 and 2005, the...

article

Impact of Tumor Spread to the Cystic Duct on the Prognosis of Patients with Gallbladder Carcinoma

Takenari Nakata, Akira Kobayashi, Shiro Miwa, Junpei Soeda, more

World Journal of Surgery > 2007 > 31 > 1 > 155-161

Introduction The importance of gallbladder carcinoma spread to the cystic duct has not yet been described. Although the cystic duct is contiguous with the gallbladder, it is located in the hepatoduodenal ligament and differs in structure from the gallbladder. The incidence and prognostic significance of cancer spread to the cystic duct in patients with gallbladder cancer is unclear. Methods Surgical...

article

Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery

Shiro Miwa, Shinichi Miyagawa, Akira Kobayashi, Yasuhiko Akahane, more

Journal of Gastroenterology > 2006 > 41 > 9 > 893-900

Background We performed hepatectomy without lymph node (LN) dissection for intrahepatic cholangiocarcinoma (ICC) limited to the peripheral region of the liver, and hepatectomy with extrahepatic bile duct resection and regional LN dissection for any types of ICC extending to the hepatic hilum. Surgical outcomes were evaluated to elucidate the prognostic factors that influence patient survival with...

article

Prognostic significance of mature dendritic cells and factors associated with their accumulation in metastatic liver tumors from colorectal cancer

Shinichi Miyagawa, Junpei Soeda, Satoshi Takagi, Shiroh Miwa, more

Human Pathology > 2004 > 35 > 11 > 1392-1396

Although dendritic cells (DCs) play an important role in tumor immunity, their prognostic significance and factors related to mature DCs have not been addressed in metastatic liver tumors. In surgically resected, paraffin-embedded tissue sections from 70 patients with colorectal liver metastasis, CD83 (a marker of mature DCs) positive cells and cancer cells positive for the terminal deoxynucleotidyl...

article

Dendritic cells, T-cell infiltration, and grp94 expression in cholangiocellular carcinoma

Satoshi Takagi, Shin-Ichi Miyagawa, Eri Ichikawa, Junpei Soeda, more

Human Pathology > 2004 > 35 > 7 > 881-886

Although dendritic cells (DCs) play an important role in tumor immunity, there have been no reports on their role in cholangiocellular carcinoma (CCC). In 26 formalin-fixed, paraffin-embedded tissue sections from patients with CCC, cells positive for CD83 (a marker of mature DCs), CD1a (a marker of immature DCs), and CD8 and CD4 (T cell markers) were counted, and expression of glucose-regulated protein...

article

Primary Abscess of the Omentum: Report of a Case

Noriaki Otagiri, Junpei Soeda, Tomoyasu Yoshino, Hisanao Chisuwa, more

Surgery Today > 2004 > 34 > 3 > 261-264

We report a case of a primary abscess of the omentum without any obvious etiology. A 62-year-old man was referred to our clinic with lower abdominal pain, and computed tomography showed an intra-abdominal abscess in the left pelvic area. Laparotomy revealed that the abscess adhered to the urinary bladder and abdominal wall, but no perforation of the alimentary tract was identified and there was no...

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INFONA - science communication portal

Search results for: Junpei Soeda

Acetylcholine induces fibrogenic effects via M2/M3 acetylcholine receptors in non‐alcoholic steatohepatitis and in primary human hepatic stellate cells

Immunomodulatory and antioxidant function of albumin stabilises the endothelium and improves survival in a rodent model of chronic liver failure

The beta‐adrenoceptor agonist isoproterenol rescues acetaminophen‐injured livers through increasing progenitor numbers by Wnt in mice

Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis

Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice

Developmental programming in the pathogenesis of non-alcoholic fatty pancreas disease in mice

Protein Engineered Variants of Hepatocyte Growth Factor/Scatter Factor Promote Proliferation of Primary Human Hepatocytes and in Rodent Liver

Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells

Pathophysiology and clinical management of non-alcoholic fatty liver disease

Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells

Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice

Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease

Clinical and pathological features of primary carcinoma of the cystic duct

Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer

Is major hepatectomy with pancreatoduodenectomy justified for advanced biliary malignancy?

Impact of Tumor Spread to the Cystic Duct on the Prognosis of Patients with Gallbladder Carcinoma

Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery

Prognostic significance of mature dendritic cells and factors associated with their accumulation in metastatic liver tumors from colorectal cancer

Dendritic cells, T-cell infiltration, and grp94 expression in cholangiocellular carcinoma

Primary Abscess of the Omentum: Report of a Case

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