Search results for: Esther Gómez-Sánchez

Items from 1 to 13 out of 13 results

article

OLFM4 polymorphisms predict septic shock survival after major surgery

Felipe Pérez‐García, Salvador Resino, Esther Gómez‐Sánchez, Hugo Gonzalo‐Benito, more

European Journal of Clinical Investigation > 51 > 4 > n/a - n/a

Background Higher expression of olfactomedin‐4 (OLFM4), a gene regulated by nuclear factor‐kappa B (NF‐κB), has been related to a higher risk of organ failure and death in patients with septic shock. We aimed to evaluate the association between OLFM4 single nucleotide polymorphisms (SNPs) and septic shock‐related death in 175 patients who underwent major surgery, as well as its performance in predicting...

article

Epidural analgesia and its implications in the maternal health in a low parity comunity

Ivan Penuela, Pilar Isasi-Nebreda, Hedylamar Almeida, Mario López, more

BMC Pregnancy and Childbirth > 2019 > 19 > 1 > 1-9

Background In regard to obstetrical analgesia management there are different results related to the use of epidural analgesia versus mechanical adverse outcomes at delivery. Methods Cohort study of 23,183 consecutive, term, singleton vaginal deliveries, including spontaneous and induced labours, at a single institution from January 2004 to June 2016 to determine the association between epidural...

article

Procalcitonin and white blood cells, combined predictors of infection in cardiac surgery patients

María Heredia-Rodríguez, Juan Bustamante-Munguira, Mario Lorenzo, Esther Gómez-Sánchez, more

Journal of Surgical Research > 2017 > 212 > C > 187-194

Sepsis is strongly associated with an increased risk of postoperative mortality, longer length of hospital stay, and elevated health care costs. Early clinical symptoms overlap with those of systemic inflammatory response syndrome, a response that commonly occurs after cardiac surgery with cardiopulmonary bypass. Since a combination of biomarkers has been demonstrated to improve the prediction of...

article

IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study

Maria Angeles Jiménez-Sousa, Luz Maria Medrano, Pilar Liu, Amanda Fernández-Rodríguez, more

Annals of Intensive Care > 2017 > 7 > 1 > 1-9

Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, being the primary cause of death from infection, especially if not recognized and treated promptly. The aim of this study was to analyze whether IL-6 rs1800795 polymorphism is associated with septic shock-related death in European white patients who underwent major surgery. Methods We performed...

article

IL‐1B rs16944 polymorphism is related to septic shock and death

María Ángeles Jiménez‐Sousa, Luz M. Medrano, Pilar Liu, Raquel Almansa, more

European Journal of Clinical Investigation > 47 > 1 > 53 - 62

Background IL‐1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyse whether IL‐1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery. Materials and methods We performed a case–control study on 467 patients who underwent major cardiac or abdominal surgery. Of them, 205 patients...

article

Procalcitonin cannot be used as a biomarker of infection in heart surgery patients with acute kidney injury

María Heredia-Rodríguez, Juan Bustamante-Munguira, Inmaculada Fierro, Mario Lorenzo, more

Journal of Critical Care > 2016 > 33 > C > 233-239

We intended to assess how acute kidney injuy impacts on procalcitonin levels in cardiac surgery patients, with or without infection, and whether procalcitonin might be used as a biomarker of infection in acute kidney injuy.A case–control study was designed which included patients that had had cardiac surgery between January 2011 and January 2015. Every patient developing severe sepsis or septic shock...

article

Defining immunological dysfunction in sepsis: A requisite tool for precision medicine

Jesús F. Bermejo-Martin, David Andaluz-Ojeda, Raquel Almansa, Francisco Gandía, more

Journal of Infection > 2016 > 72 > 5 > 525-536

Immunological dysregulation is now recognised as a major pathogenic event in sepsis. Stimulation of immune response and immuno-modulation are emerging approaches for the treatment of this disease. Defining the underlying immunological alterations in sepsis is important for the design of future therapies with immuno-modulatory drugs.Clinical studies evaluating the immunological response in adult patients...

article

Predicting cardiac surgery–associated acute kidney injury: The CRATE score

Pablo Jorge-Monjas, Juan Bustamante-Munguira, Mario Lorenzo, María Heredia-Rodríguez, more

Journal of Critical Care > 2016 > 31 > 1 > 130-138

Acute kidney injury (AKI) is a frequent complication after cardiac surgery and is associated with increased mortality. The aim was to design a nondialytic AKI score in patients with previously normal renal function undergoing cardiac surgery.Data were collected on 909 patients who underwent cardiac surgery with cardiopulmonary bypass between 2012 and 2014. A total of 810 patients fulfilled the inclusion...

article

Impact of ventilator-associated pneumonia on mortality and epidemiological features of patients with secondary peritonitis

María Heredia-Rodríguez, María Teresa Peláez, Inmaculada Fierro, Esther Gómez-Sánchez, more

Annals of Intensive Care > 2016 > 6 > 1 > 1-9

Background Despite the significant impact of nosocomial infections on the morbidity and mortality of patients staying in the intensive care unit (ICU), no study over the past 20 years has focused specifically on VAP following secondary peritonitis. The objective of the present study was to determine in-hospital mortality and epidemiological features attributed to ventilator-associated pneumonia (VAP)...

article

Transcriptomic correlates of organ failure extent in sepsis

Raquel Almansa, María Heredia-Rodríguez, Esther Gomez-Sanchez, David Andaluz-Ojeda, more

Journal of Infection > 2015 > 70 > 5 > 445-456

Sepsis is characterised by the frequent presence of organ failure and marked immunologic alterations. We studied the association between the extent of organ failure and the transcriptomic response of septic patients.Gene expression profiles in the blood of 74 surgical patients with sepsis were compared with those of 30 surgical patients with no sepsis. Differentially expressed genes were assessed...

article

Erratum to: Development of the Post Cardiac Surgery (POCAS) prognostic score

Eduardo Tamayo, Inma Fierro, Juan Bustamante-Munguira, María Heredia-Rodríguez, more

Critical Care > 2015 > 19 > 1 > 1-4

article

Transcriptomic evidence of impaired immunoglobulin G production in fatal septic shock

Raquel Almansa, Eduardo Tamayo, María Heredia, Sandra Gutierrez, more

Journal of Critical Care > 2014 > 29 > 2 > 307-309

article

Development of the Post Cardiac Surgery (POCAS) prognostic score

Eduardo Tamayo, Inma Fierro, Juan Bustamante-Munguira, María Heredia-Rodríguez, more

Critical Care > 2013 > 17 > 5 > 1-10

Introduction The risk of mortality in cardiac surgery is generally evaluated using preoperative risk-scale models. However, intraoperative factors may change the risk factors of patients, and the organism functionality parameters determined upon ICU admittance could therefore be more relevant in deciding operative mortality. The goals of this study were to find associations between the general parameters...

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