Search results for: José Manuel García‐Aznar

Items from 1 to 20 out of 27 results

article

Effects of tumour heterogeneous properties on modelling the transport of radiative particles

Victor Ogesa Juma, Diego Sainz‐DeMena, María Teresa Sánchez, José Manuel García‐Aznar

International Journal for Numerical Methods in Biomedical Engineering > 39 > 11 > n/a - n/a

Dose calculation plays a critical role in radiotherapy (RT) treatment planning, and there is a growing need to develop accurate dose deposition models that incorporate heterogeneous tumour properties. Deterministic models have demonstrated their capability in this regard, making them the focus of recent treatment planning studies as they serve as a basis for simplified models in RT treatment planning...

article

A novel algorithm to resolve lack of convergence and checkerboard instability in bone adaptation simulations using non‐local averaging

José Luis Calvo‐Gallego, Peter Pivonka, José Manuel García‐Aznar, Javier Martínez‐Reina

International Journal for Numerical Methods in Biomedical Engineering > 37 > 2 > n/a - n/a

Checkerboard is a typical instability in finite element (FE) simulations of bone adaptation and topology optimization in general. It consists in a patchwork pattern with elements of alternating stiffness, producing lack of convergence and instabilities in the predicted bone density. Averaging techniques have been proposed to solve this problem. One of the most acknowledged techniques (node based formulation)...

article

An agent-based and FE approach to simulate cell jamming and collective motion in epithelial layers

Ismael González-Valverde, José Manuel García-Aznar

Computational Particle Mechanics > 2019 > 6 > 1 > 85-96

The collective cell motion in epithelial layers is still poorly understood, despite this phenomenon being fundamental to explain several biological processes. Indeed, it has been experimentally observed that epithelial cells can behave either as a fluid or as a solid in the tissue. The transition between both states is related to cell–cell adhesions and cell morphology. In fact, cell motility can...

article

A hybrid computational model for collective cell durotaxis

Jorge Escribano, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, more

Biomechanics and Modeling in Mechanobiology > 2018 > 17 > 4 > 1037-1052

Collective cell migration is regulated by a complex set of mechanical interactions and cellular mechanisms. Collective migration emerges from mechanisms occurring at single cell level, involving processes like contraction, polymerization and depolymerization, of cell–cell interactions and of cell–substrate adhesion. Here, we present a computational framework which simulates the dynamics of this emergent...

article

A hybrid computational model to explore the topological characteristics of epithelial tissues

Ismael González‐Valverde, José Manuel García‐Aznar

International Journal for Numerical Methods in Biomedical Engineering > 33 > 11 > n/a - n/a

Epithelial tissues show a particular topology where cells resemble a polygon‐like shape, but some biological processes can alter this tissue topology. During cell proliferation, mitotic cell dilation deforms the tissue and modifies the tissue topology. Additionally, cells are reorganized in the epithelial layer and these rearrangements also alter the polygon distribution. We present here a computer‐based...

article

The role of nuclear mechanics in cell deformation under creeping flows

Francisco Serrano-Alcalde, José Manuel García-Aznar, María José Gómez-Benito

Journal of Theoretical Biology > 2017 > 432 > C > 25-32

Despite the relevant regulatory role that nuclear deformation plays in cell behaviour, a thorough understanding of how fluid flow modulates the deformation of the cell nucleus in non-confined environments is lacking. In this work, we investigated the dynamics of cell deformation under different creeping flows as a general simulation tool for predicting nuclear stresses and strains. Using this solid–fluid...

article

Numerical analysis of an osteoconduction model arising in bone‐implant integration

José R. Fernández, José Manuel García‐Aznar, María Masid

ZAMM ‐ Journal of Applied Mathematics and Mechanics / Zeitschrift für... > 97 > 9 > 1050 - 1063

In this paper, we study, from a numerical point of view, an osseointegrated model depending on the density of the osteogenic cells and osteoblasts and one generic growth factor. The problem is written as a coupled system of nonlinear partial differential equations and an ordinary differential equation. The variational formulation leads to two coupled parabolic nonlinear variational equations. Then,...

article

Erratum to: Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons

Laura Urrea, Miriam Segura-Feliu, Masami Masuda-Suzukake, Arnau Hervera, more

Molecular Neurobiology > 2018 > 55 > 3 > 1861-1861

The online version of the original article can be found under doi:10.1007/s12035-017-0451-4

article

Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons

Laura Urrea, Miriam Segura-Feliu, Masami Masuda-Suzukake, Arnau Hervera, more

Molecular Neurobiology > 2018 > 55 > 3 > 1847-1860

The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although...

article

Computational mechano-chemo-biology: a tool for the design of tissue scaffolds

Jose Manuel Garcia Aznar, Clara Valero, Carlos Borau, Noelia Garijo

Biomanufacturing Reviews > 2016 > 1 > 1 > 1-10

Computational modeling is usually employed for simulation, design and manufacturing of tissue scaffolds, specially focused on macroscopic and microscopic properties, relying on anatomy and geometrical constraints. However, these models typically require to take into account the effects of cell-matrix interaction due to its crucial influence on a range of cellular processes including cell adhesion,...

article

Quantification of angiogenic sprouting under different growth factors in a microfluidic platform

Cristina Del Amo, Carlos Borau, Raquel Gutiérrez, Jesús Asín, more

Journal of Biomechanics > 2016 > 49 > 8 > 1340-1346

Angiogenesis, as example of collective migration of endothelial cells (ECs), is the main dynamic process that culminates in sprout formation from existing vessels. After tissue injury, the vascularity is interrupted, triggering the regeneration process and the release of different growth factors (GFs). The main aim of this work is to quantify the effect of specific GFs during the initial stage of...

article

An unstructured immersed finite element method for nonlinear solid mechanics

Thomas Rüberg, Fehmi Cirak, José Manuel García Aznar

Advanced Modeling and Simulation in Engineering Sciences > 2016 > 3 > 1 > 1-28

We present an immersed finite element technique for boundary-value and interface problems from nonlinear solid mechanics. Its key features are the implicit representation of domain boundaries and interfaces, the use of Nitsche’s method for the incorporation of boundary conditions, accurate numerical integration based on marching tetrahedrons and cut-element stabilisation by means of extrapolation...

article

Preface: Particle-based simulations on cell and biomolecular mechanics

José Manuel García-Aznar

Computational Particle Mechanics > 2015 > 2 > 4 > 315-315

article

Is the callus shape an optimal response to a mechanobiological stimulus?

Frederico O. Ribeiro, João Folgado, José Manuel Garcia-Aznar, María José Gómez-Benito, more

Medical Engineering and Physics > 2014 > 36 > 11 > 1508-1514

After bone trauma, the natural response to restore bone function is the formation of a callus around the fracture. Although several bone healing models have been developed, none have effectively perceived early callus formation and shape as the result of an optimal response to a mechanobiological stimulus.In this paper, we investigate which stimulus regulates early callus formation. An optimal design...

article

A coupled mechano-biochemical model for bone adaptation

Václav Klika, Maria Angelés Pérez, José Manuel García-Aznar, František Maršík, more

Journal of Mathematical Biology > 2014 > 69 > 6-7 > 1383-1429

Bone remodelling is a fundamental biological process that controls bone microrepair, adaptation to environmental loads and calcium regulation among other important processes. It is not surprising that bone remodelling has been subject of intensive both experimental and theoretical research. In particular, many mathematical models have been developed in the last decades focusing in particular aspects...

article

A time-dependent phenomenological model for cell mechano-sensing

Carlos Borau, Roger D. Kamm, José Manuel García-Aznar

Biomechanics and Modeling in Mechanobiology > 2014 > 13 > 2 > 451-462

Adherent cells normally apply forces as a generic means of sensing and responding to the mechanical nature of their surrounding environment. How these forces vary as a function of the extracellular rigidity is critical to understanding the regulatory functions that drive important phenomena such as wound healing or muscle contraction. In recognition of this fact, experiments have been conducted to...

article

Culture of human bone marrow-derived mesenchymal stem cells on of poly(l-lactic acid) scaffolds: potential application for the tissue engineering of cartilage

Iñigo Izal, Pablo Aranda, Patricia Sanz-Ramos, Purificación Ripalda, more

Knee Surgery, Sports Traumatology, Arthroscopy > 2013 > 21 > 8 > 1737-1750

Purpose Due to the attractive properties of poly(l-lactic acid) (PLLA) for tissue engineering, the aim was to determine the growth and differentiation capacity of mesenchymal stromal cells (MSCs) in PLLA scaffolds and their potential use in the treatment of cartilage diseases. Methods MSCs were cultured in PLLA films and thin porous membranes to study adherence and proliferation. Permeability and...

article

Numerical method for the bone regeneration model, defined within the evolving 2D axisymmetric physical domain

Pavel A. Prokharau, Fred J. Vermolen, José Manuel García-Aznar

Computer Methods in Applied Mechanics and Engineering > 2013 > 253 > Complete > 117-145

A numerical algorithm, used to obtain a solution for a peri-implant osseointegration model is constructed. The model is formulated in terms of a system of three nonlinear coupled time-dependent advection–diffusion–reaction equations, which are defined within the irregular two dimensional physical domain, which evolves in time. The embedded boundary method and the level set function, which is approximated...

article

Model for direct bone apposition on pre-existing surfaces, during peri-implant osseointegration

Pavel A. Prokharau, Fred J. Vermolen, José Manuel García-Aznar

Journal of Theoretical Biology > 2012 > 304 > Complete > 131-142

In the present paper, a model for the early stages of peri-implant bone regeneration is developed. This model is able to capture some important characteristics of endosseous healing, which were not incorporated in the existing models. It is a well known fact, that during peri-implant osseointegration, bone forms only by apposition on the pre-existing rigid surface, which initially consists of the...

article

MECHANOBIOLOGICAL MODELING OF CELL MIGRATION: APPLICATION TO DISTRACTION OSTEOGENESIS

Esther Reina-Romo, María José Gómez-Benito, Jaime Domínguez, José Manuel García-Aznar

Journal of Biomechanics > 2012 > 45 > Supplement 1 > S216

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Keywords

FINITE ELEMENT SIMULATION (3)
BONE REGENERATION (2)
FINITE ELEMENT METHOD (2)
MICROFLUIDICS (2)
MOVING BOUNDARY (2)
OSSEOINTEGRATION (2)
65M12 (1)
65M15 (1)
65M60 (1)
74L15 (1)
92C17 (1)
A PRIORI ERROR ESTIMATES (1)
ADVECTION–DIFFUSION–REACTION SYSTEM (1)
AGENT‐BASED MODEL (1)
AMYLOID SPREADING (1)
ANGIOGENESIS (1)
BIOLOGICAL STIMULUS (1)
BMU (1)
BOLTZMANN TRANSPORT EQUATION (1)
BONE ADAPTATION (1)
BONE CELLS (1)
BONE HEALING (1)
BONE IMPLANT (1)
BONE REMODELING (1)
BONE REMODELLING (1)
BOUNDARY ELEMENTS (1)
CALLUS SHAPE (1)
CELL CONTRACTILITY (1)
CELL CYCLE AND CELL PROLIFERATION (1)
CELL DEFORMATION (1)
CELL DIFFERENTIATION (1)
CELL MECHANICS (1)
CELL PLASTICITY (1)
CELL-MATERIAL INTERACTION (1)
CELL‐CELL INTERACTION (1)
CELL–MATRIX INTERACTION (1)
CHECKERBOARD (1)
CHONDROCYTE DIFFERENTIATION (1)
COLLECTIVE CELL MIGRATION (1)
COLLECTIVE CELL MOTION (1)
COMPUTATIONAL MECHANO-BIOLOGY (1)
COMPUTATIONAL MODEL (1)
COMPUTER-AIDED TISSUE ENGINEERING (1)
CONTACT AND DISTANCE OSTEOGENESIS (1)
CONVERGENCE (1)
CORTICAL BONE (1)
CSG MODELLING (1)
CUT-ELEMENT STABILISATION (1)
DAMAGE (1)
DAMAGE MECHANICS (1)
DIPG (1)
DISTANCE AND CONTACT OSTEOGENESIS (1)
DUAL POROSITY (1)
DUROTAXIS (1)
EMBEDDED BOUNDARY (1)
EMERGENT SIMULATION OF CELL MONOLAYERS (1)
EXTERNAL BONE REMODELING (1)
FE ANALYSIS (1)
FINITE ELEMENT ANALYSIS (1)
FINITE ELEMENTS (1)
FINITE VOLUME METHOD (1)
FLUID–STRUCTURE INTERACTION (1)
GROOVE (1)
GROWTH FACTOR (1)
GROWTH FACTORS (1)
HYBRID MODEL (1)
HYBRID MODELING APPROACH (1)
HYBRID MODELLING (1)
IMMERSED FINITE ELEMENTS (1)
IMPLANT MICROTOPOGRAPHY (1)
IMPLICIT GEOMETRY (1)
INTERSTITIAL FLUID FLOW (1)
LEVEL SET METHOD (1)
MATHEMATICAL MODELLING (1)
MECHANICAL STIMULUS (1)
MECHANICS OF CELL MIGRATION (1)
MECHANO-BIOCHEMICAL MODEL (1)
MECHANO-SENSING (1)
MECHANOBIOLOGY (1)
MECHANOSTAT THEORY (1)
MECHANOTAXIS (1)
MESENCHYMAL STEM CELLS (1)
METHOD OF LINES (1)
MICROFLUIDIC DEVICES (1)
MINERALIZATION (1)
MODELING (1)
MOTOR ACTIVATION (1)
NEUROBLASTOMA (1)
NITSCHE’S METHOD (1)
NONLINEAR SOLID MECHANICS (1)
NUCLEUS MECHANICAL PROPERTIES (1)
NUMERICAL METHODS (1)
NUMERICAL SIMULATIONS (1)
OSTEOCONDUCTION (1)
PHOTON TRANSPORT (1)
PLLA SCAFFOLDS (1)
POROELASTICITY (1)
PRNP (1)
RADIATIVE PARTICLE TRANSPORT (1)
RANKL-RANK-OPG PATHWAY (1)
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Elsevier (12)
Springer (11)
Wiley (4)

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Search results for: José Manuel García‐Aznar

Effects of tumour heterogeneous properties on modelling the transport of radiative particles

A novel algorithm to resolve lack of convergence and checkerboard instability in bone adaptation simulations using non‐local averaging

An agent-based and FE approach to simulate cell jamming and collective motion in epithelial layers

A hybrid computational model for collective cell durotaxis

A hybrid computational model to explore the topological characteristics of epithelial tissues

The role of nuclear mechanics in cell deformation under creeping flows

Numerical analysis of an osteoconduction model arising in bone‐implant integration

Erratum to: Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons

Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons

Computational mechano-chemo-biology: a tool for the design of tissue scaffolds

Quantification of angiogenic sprouting under different growth factors in a microfluidic platform

An unstructured immersed finite element method for nonlinear solid mechanics

Preface: Particle-based simulations on cell and biomolecular mechanics

Is the callus shape an optimal response to a mechanobiological stimulus?

A coupled mechano-biochemical model for bone adaptation

A time-dependent phenomenological model for cell mechano-sensing

Culture of human bone marrow-derived mesenchymal stem cells on of poly(l-lactic acid) scaffolds: potential application for the tissue engineering of cartilage

Numerical method for the bone regeneration model, defined within the evolving 2D axisymmetric physical domain

Model for direct bone apposition on pre-existing surfaces, during peri-implant osseointegration

MECHANOBIOLOGICAL MODELING OF CELL MIGRATION: APPLICATION TO DISTRACTION OSTEOGENESIS

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