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Thrombin activity enhancement and its receptor protease‐activated receptor 1 (PAR‐1) activation play vital roles in neurologic deficits in the central nervous system. Our recent study showed that PAR‐1 upregulation stimulated by chronic high glucose (HG) caused central neuron injury through neuroinflammation; however, the molecular mechanisms are far from clear. In the present study, we found that...
Sarsasapogenin (Sar), a natural steroidal compound, shows neuroprotection, cognition‐enhancement, antiinflammation, antithrombosis effects, and so on. However, whether Sar has ameliorative effects on diabetes‐associated cognitive impairment remains unknown. In this study, we found that Sar ameliorated diabetes‐associated memory impairment in streptozotocin‐induced diabetic rats, evidenced by increased...
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