Search results for: Shaowu Cheng

Items from 1 to 15 out of 15 results

article

A multi-aircraft conflict detection and resolution method for 4-dimensional trajectory-based operation

Siqi HAO, Shaowu CHENG, Yaping ZHANG

Chinese Journal of Aeronautics > 2018 > 31 > 7 > 1579-1593

Conflict Detection and Resolution (CD&R) is the key to ensure aviation safety based on Trajectory Prediction (TP). Uncertainties that affect aircraft motions cause difficulty in an accurate prediction of the trajectory, especially in the context of four-dimensional (4D) Trajectory-Based Operation (4DTBO), which brings the uncertainty of pilot intent. This study draws on the idea of time geography,...

article

Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density

David Hottman, Shaowu Cheng, Andrea Gram, Kyle LeBlanc, more

Neuroscience > 2018 > 373 > C > 207-217

Isoprenoids and prenylated proteins regulate a variety of cellular functions, including neurite growth and synaptic plasticity. Importantly, they are implicated in the pathogenesis of several diseases, including Alzheimer’s disease (AD). Recently, we have shown that two protein prenyltransferases, farnesyltransferase (FT) and geranylgeranyltransferase-1 (GGT), have differential effects in a mouse...

article

Lianqinjiedu decoction attenuates LPS-induced inflammation and acute lung injury in rats via TLR4/NF-κB pathway

Guiming Deng, Hai He, Zheng Chen, Linqi OuYang, more

Biomedicine & Pharmacotherapy > 2017 > 96 > C > 148-152

Acute lung injury (ALI) and its severe form acute respiratory distress syndrome remain the leading cause of morbidity and mortality. LianQinJieDu (LQJD), which is a traditional Chinese medicine, has been clinically used for antiviral drug. The present study investigated whether Lianqinjiedu(LQJD) ameliorates lipopolysaccharide(LPS)-induced acute lung injury in rats and aimed to determine the anti-inflammatory...

article

Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice

Shaowu Cheng, Willayat Y. Wani, David A. Hottman, Angela Jeong, more

Journal of Neurochemistry > 142 > 2 > 297 - 304

Autophagy and lysosomal function are important for protein homeostasis and their dysfunction have been associated with Alzheimer's disease (AD). Increased immunoreactivities of an important lysosomal protease, cathepsin D (Cat D), are evident in amyloid plaques and neurons in patients with AD. This study tests the hypothesis that deleting one allele of the cathepsin D gene (Ctsd) impacts cerebral...

article

Simulation analysis of factors affecting air route connection in China

Yaping Zhang, Ting Peng, Chuanyun Fu, Shaowu Cheng

Journal of Air Transport Management > 2016 > 50 > Complete > 12-20

In order to explore the impacts of various factors on air route connection, a probability model is constructed to simulate the Chinese airline network (CAN) in 2010, and the influences of tertiary industry output, degree and the spatial distance between two navigable cities on the analog results are discussed. Our research shows that, the opening of an air route is not completely determined by the...

article

HDL and cognition in neurodegenerative disorders

David A. Hottman, Dustin Chernick, Shaowu Cheng, Zhe Wang, more

Neurobiology of Disease > 2014 > 72 > Part A > 22-36

High-density lipoproteins (HDLs) are a heterogeneous group of lipoproteins composed of various lipids and proteins. HDL is formed both in the systemic circulation and in the brain. In addition to being a crucial player in the reverse cholesterol transport pathway, HDL possesses a wide range of other functions including anti-oxidation, anti-inflammation, pro-endothelial function, anti-thrombosis, and...

chapter

Comparative study on forecasting method of departure flight baggage demand

Shaowu Cheng, Qian Gao, Yapping Zhang

Proceedings of 2014 IEEE Chinese Guidance, Navigation and Control Conference > 1600 - 1605

2014 IEEE Chinese Guidance, Navigation and Control Conference (CGNCC)

In order to provide a scientific basis for the resource allocation in the stage of checked baggage, improve the service efficiency of airport passenger terminal. According to the flight data of an international airport passenger terminal in 2012 May, this paper establish the BP artificial neural network and multiple regression prediction models respectively, in which the influencing factors are decided...

article

Simvastatin Treatment Enhances NMDAR-Mediated Synaptic Transmission by Upregulating the Surface Distribution of the GluN2B Subunit

Marc-Alexander L. T. Parent, David A. Hottman, Shaowu Cheng, Wei Zhang, more

Cellular and Molecular Neurobiology > 2014 > 34 > 5 > 693-705

The ramifications of statins on plasma cholesterol and coronary heart disease have been well documented. However, there is increasing evidence that inhibition of the mevalonate pathway may provide independent neuroprotective and procognitive pleiotropic effects, most likely via inhibition of isoprenoids, mainly farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP). FPP and GGPP are...

article

Heightened cholinergic selective neuronal vulnerability caused by GRK5 deficiency

William Suo, Shaowu Cheng, Minchao He

Alzheimer's & Dementia > 2012 > 8 > 4(S) > P646

article

Isoprenoids and Related Pharmacological Interventions: Potential Application in Alzheimer’s Disease

Ling Li, Wei Zhang, Shaowu Cheng, Dongfeng Cao, more

Molecular Neurobiology > 2012 > 46 > 1 > 64-77

Two major isoprenoids, farnesyl pyrophosphate and geranylgeranyl pyrophosphate, serve as lipid donors for the posttranslational modification (known as prenylation) of proteins that possess a characteristic C-terminal motif. The prenylation reaction is catalyzed by prenyltransferases. The lipid prenyl group facilitates to anchor the proteins in cell membranes and mediates protein–protein interactions...

article

Differential effects of melatonin on amyloid‐β peptide 25–35‐induced mitochondrial dysfunction in hippocampal neurons at different stages of culture

Weiguo Dong, Fang Huang, Wenguo Fan, Shaowu Cheng, more

Journal of Pineal Research > 48 > 2 > 117 - 125

Abstract: β‐Amyloid (Aβ) is strongly involved in the pathogenesis of Alzheimer’s disease (AD), and mitochondria play an important role in neurodegenerative disorders. To determine whether any different effect of melatonin on cultured neurons treated with Aβ in vitro and which may be produced through its different action on mitochondria at different stages of culture, we investigated the damage of...

chapter

Bus arrival time prediction model based on APC data

Shaowu Cheng, Baoyi Liu, Botao Zhai

6th Advanced Forum on Transportation of China (AFTC 2010) > 165 - 169

6th Advanced Forum on Transportation of China (AFTC 2010)

Bus arrival times are influenced by stochastic variations in number of factors, (e.g., intersection delays, traffic congestion, and weather conditions) resulting in buses to deviate from the predetermined schedule and lengthening of passenger waiting times for buses. Providing passengers with accurate bus arrival times through advanced traveler information systems can help passengers' decision making...

article

Bone mesenchymal stem cells for gene transfer of NGF to the adult rat brain: Rescue the NGFR p75 positive neurons from fimbria–fornix lesion-induced degeneration

Shuilong Leng, Junfeng He, Wenguo Fan, Shaowu Cheng, more

Neuroscience Letters > 2008 > 448 > 3 > 282-287

The study was to evaluate the therapeutic benefit of transplanted bone mesenchymal stem cells (BMSCs) transfected never growth factor (NGF) gene and GFP gene (as a reporter gene), in treating the rat with fimbria–fornix lesion. After transduction of NGF gene via recombinant retroviral vectors into the rat BMSCs, BMSCs were therefore transformed into the GFP–NGF positive BMSCs, nearly 100% of BMSCs...

article

Expression and colocalization of NADPH-diaphorase and heme oxygenase-2 in trigeminal ganglion and mesencephalic trigeminal nucleus of the rat

Wenguo Fan, Weiguo Dong, Shuilong Leng, Dongpei Li, more

Journal of Molecular Histology > 2008 > 39 > 4 > 427-433

Carbon monoxide (CO) and nitric oxide (NO) are two endogenously produced gases that can function as second messenger molecules in the nervous system. The enzyme systems responsible for CO and NO biosynthesis are heme oxygenase (HO) and nitric oxide synthase (NOS), respectively. The present study was undertaken to examine the distribution of HO-2 and NOS of the trigeminal primary afferent neurons of...

chapter

An agile method of modeling business process simulation for virtual enterprises

Shaowu Cheng, Xiaofei Xu, Gang Wang, Quanlong Li

IEEE International Conference on e-Business Engineering (ICEBE'5) > 87 - 92

IEEE International Conference on e-Business Engineering

The agility of modeling business process simulation (BPS) is required by virtual enterprises. Firstly with some new concepts, such as the atomic business process simulation model (BPSM) and the business process simulation federation (BPSF) etc., a frame of business process simulation model for virtual enterprises (VE-BPSM) is presented. Business processes of a member enterprise are classified into...

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