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Despite numerous efforts, the accurate determination of trace biomolecules with zeptomolar sensitivity remains elusive. Here, a 3D carbon nanomaze (CAM) electrode for the ultrasensitive detection of trace biomolecules such as nucleic acids, proteins, and extracellular vesicles is reported. The CAM electrode consists of an interlaced carbon fiber array on which intercrossed graphene sheets are vertically...
In article number 2006521, Danqun Huo, Yang Luo, Changjun Hou, and co‐workers present a universal 3D carbon nanomaze (CAM) biosensing platform by integrating a programmable 3D DNAT‐ structured probe and in situ grown graphene sheets for the zeptomolar level detection of cancer biomarkers with a lowest LOD of 23 zM. Through simple functionalization by appending various biomolecular probes of interest,...
Direct tracing of small extracellular vesicle (sEV) cargoes holds unprecedented importance for elucidating the mechanisms involved in intercellular communication. However, high‐fidelity determination of sEVs’ molecular cargoes in situ has yet to be achieved due to the difficulty in transporting molecular probes into intact sEVs. Herein, a fLuorescent Intracellular‐Guided Hairpin‐Tetrahedron (fLIGHT)...
In article number 2002800, Guixue Wang, Yang Luo, and co‐workers introduce a DNA origami nanoprobe “fLIGHT” for high‐fidelity visualization of small extracellular vesicle microRNAs without RNA extraction. This innovative platform can aid in easy development of a universal molecular detection strategy that could facilitate extracellular vesicle‐derived fundamental biological studies.
Real‐time quantitative monitoring of miRNAs plays an essential role in diagnosis and therapeutics. Herein, a DSN‐coupled graphene nanoarray/gold nanoparticles (GNAs/AuNPs) carbon paper (CP) electrode for the dynamic, sensitive, and real‐time analysis of miRNAs is reported. GNAs are vertically grown on the conductive CP by radio frequency plasma enhanced chemical vapor deposition, and AuNPs are electrodeposited...
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