Wyniki wyszukiwania dla: Tomasz Dziaman

Pozycje od 1 do 10 spośród 10 wyników

artykuł

Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents

Maciej Przybyłek, Anna Kowalska, Natalia Tymorek, Tomasz Dziaman, więcej

4078

The thermodynamic properties of phenacetin in solid state and in saturated conditions in neat and binary solvents were characterized based on differential scanning calorimetry and spectroscopic solubility measurements. The temperature-related heat capacity values measured for both the solid and melt states were provided and used for precise determination of the values for ideal solubility, fusion...

artykuł

In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease

Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Tomasz Dziaman, więcej

Journal of Translational Medicine > 2018 > 16 > 1 > 1-11

Background A characteristic feature of malignant cells, such as colorectal cancer cells, is a profound decrease in the level of 5-hydroxymethylcytosine, a product of 5-methylcytosine oxidation by TET enzymes. Recent studies showed that ascorbate may upregulate the activity of TET enzymes in cultured cells and enhance formation of their products in genomic DNA. Methods The study included four groups...

artykuł

Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease

Tomasz Dziaman, Daniel Gackowski, Jolanta Guz, Kinga Linowiecka, więcej

Clinical Epigenetics > 2018 > 10 > 1 > 1-11

Background Active demethylation of 5-methyl-2′-deoxycytidine (5-mdC) in DNA occurs by oxidation to 5-(hydroxymethyl)-2′-deoxycytidine (5-hmdC) and further oxidation to 5-formyl-2′-deoxycytidine (5-fdC) and 5-carboxy-2′-deoxycytidine (5-cadC), and is carried out by enzymes of the ten-eleven translocation family (TETs 1, 2, 3). Decreased level of epigenetic DNA modifications in cancer tissue may be...

artykuł

8‐Oxo‐7,8‐dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients

Tomasz Dziaman, Zbigniew Banaszkiewicz, Krzysztof Roszkowski, Daniel Gackowski, więcej

International Journal of Cancer > 134 > 2 > 376 - 383

The aim of this work was to answer the question whether the broad range of parameters which describe oxidative stress and oxidatively damaged DNA and repair are appropriate prognosis factors of colon cancer (CRC) patients survival? The following parameters were analyzed for 89 CRC patients: concentration of uric acid and vitamins A, E, C in plasma; levels of 8‐oxodGuo (8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine)...

artykuł

Benefits and Risks of Iron Supplementation in Anemic Neonatal Pigs

Paweł Lipiński, Rafał R. Starzyński, François Canonne-Hergaux, Barbara Tudek, więcej

The American Journal of Pathology > 2010 > 177 > 3 > 1233-1243

Iron deficiency is a common health problem. The most severe consequence of this disorder is iron deficiency anemia (IDA), which is considered the most common nutritional deficiency worldwide. Newborn piglets are an ideal model to explore the multifaceted etiology of IDA in mammals, as IDA is the most prevalent deficiency disorder throughout the early postnatal period in this species and frequently...

artykuł

The effect of oxidative stress on nucleotide-excision repair in colon tissue of newborn piglets

Sabine A.S. Langie, Pawel Kowalczyk, Barbara Tudek, Romuald Zabielski, więcej

Mutation Research - Genetic Toxicology and Environmental Mutagenesis > 2010 > 695 > 1-2 > 75-80

Nucleotide-excision repair (NER) is important for the maintenance of genomic integrity and to prevent the onset of carcinogenesis. Oxidative stress was previously found to inhibit NER in vitro, and dietary antioxidants could thus protect DNA not only by reducing levels of oxidative DNA damage, but also by protecting NER against oxidative stress-induced inhibition. To obtain further insight in the...

artykuł

The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas

Jolanta Guz, Marek Foksinski, Agnieszka Siomek, Daniel Gackowski, więcej

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis > 2008 > 640 > 1-2 > 170-173

It has been known for a long time that DNA hypomethylation occurs in many human cancers and precancerous conditions. However, the mechanisms of hypomethylation are largely unknown. It is possible that endogenous 8-oxo-7,8-dihydroguanine (8-oxoGua) level may be linked to aberrant DNA methylation of adjacent cytosine and in this way influences carcinogenesis. Therefore, the aim of the present study...

artykuł

Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia

Daniel Gackowski, Rafal Rozalski, Agnieszka Siomek, Tomasz Dziaman, więcej

Journal of the Neurological Sciences > 2008 > 266 > 1-2 > 57-62

Oxidative DNA damage may contribute to neuronal cell loss and may be involved in pathogenesis of some neurodegenerative diseases. We assessed the broad spectrum of oxidative DNA damage biomarkers and antioxidants in mixed Alzheimer disease/vascular dementia (MD) and in control patients.The amount of the products of oxidative DNA damage repair (8-oxo-2′-deoxyguanosine and 8-oxoguanine) excreted into...

artykuł

Effects of basal level of antioxidants on oxidative DNA damage in humans

Marek Foksinski, Daniel Gackowski, Rafal Rozalski, Agnieszka Siomek, więcej

European Journal of Nutrition > 2007 > 46 > 3 > 174-180

Background Vitamins A, E and C, and uric acid, which can scavenge free radicals should also protect DNA from the damage. It is reasonable to assume that agents that decrease oxidative DNA damage should also decrease subsequent cancer development. Aim of the study A relationship between basal level of antioxidants (vitamins A, C and E and uric acid) and oxidative DNA damage was assessed. For the...

artykuł

Oxidative damage to DNA and antioxidant status in aging and age-related diseases

Ryszard Olinski, Agnieszka Siomek, Rafal Rozalski, Daniel Gackowski, więcej

Acta Biochimica Polonica > 2007 > 54 > 1 > 11-26

Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which...

Opcje filtrowania

Data publikacji

Ustaw własny zakres dat

Słowa kluczowe

OXIDATIVE STRESS (3)
ANTIOXIDANTS (2)
COLON CANCER (2)
OXIDATIVE DNA DAMAGE (2)
5-METHYLCYTOSINE (1)
8-OXODEOXYGUANINE (1)
8-OXODG (1)
8‐OXOGUA (1)
ADENOMA (1)
AGE-RELATED DISEASES (1)
AGING (1)
ALZHEIMER DISEASE (1)
ANTIOXIDANT VITAMINS (1)
ASCORBATE (1)
BER (1)
CEREBROSPINAL FLUID (1)
CO-SOLVENCY (1)
COLON ADENOMA AND CARCINOMA PATIENTS (1)
COLON POLYP (1)
COLORECTAL CANCER (1)
DEMETHYLATION (1)
DNA DAMAGE/REPAIR (1)
DNA DEMETHYLATION (1)
DNA EPIGENETIC MODIFICATION (1)
DNA REPAIR (1)
DNA-REPAIR CAPACITY (1)
EPIGENETIC DNA MODIFICATIONS (1)
EXCESS SOLUBILITY (1)
FUSION THERMODYNAMICS (1)
GO SYSTEM (1)
HEALTHY SUBJECT (1)
HEAT CAPACITY (1)
IBD (1)
IDEAL SOLUBILITY (1)
INFLAMMATORY BOWEL DISEASE (1)
MIXED DEMENTIA (1)
OXIDATIVE DAMAGE TO DNA (1)
PHENACETIN (1)
ROS (1)
SURVIVAL (1)
SYNERGISTIC EFFECT (1)
TEN-ELEVEN TRANSLOCATION PROTEIN (1)
URIC ACID (1)
więcej

Zbiór danych

Elsevier (4)
Springer (3)
Infona (1)
PSJD (1)
Wiley (1)

INFONA - portal komunikacji naukowej

Wyniki wyszukiwania dla: Tomasz Dziaman

Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents

In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease

Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease

8‐Oxo‐7,8‐dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients

Benefits and Risks of Iron Supplementation in Anemic Neonatal Pigs

The effect of oxidative stress on nucleotide-excision repair in colon tissue of newborn piglets

The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas

Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia

Effects of basal level of antioxidants on oxidative DNA damage in humans

Oxidative damage to DNA and antioxidant status in aging and age-related diseases

Opcje filtrowania

Data publikacji

Słowa kluczowe

Zbiór danych

Czasopismo

INFONA - portal komunikacji naukowej

Wyniki wyszukiwania dla: Tomasz Dziaman

Dodaj adresata

Anulowanie wysłania wiadomości

Czy na pewno chcesz anulować wysłanie wiadomości?

Wyślij wiadomość

Opcje filtrowania

Data publikacji

Ustawianie zakresu dat

Podaj zakres dat dla filtrowania wyświetlonych wyników. Możesz podać datę początkową, końcową lub obie daty. Daty możesz wpisać ręcznie lub wybrać za pomocą kalendarza.

Słowa kluczowe

Zbiór danych

Czasopismo

Zgłaszanie błędu / nadużycia

Nieudane wysłanie zgłoszenia

Ułatwienia dostępu