Spinal epidural abscess (SEA) is a rare infectious disease. However, if left unrecognized and untreated, the clinical outcome of SEA can be devastating.To report a rare clinical presentation of a cervicothoracolumbar SEA with cerebral salt wasting (CSW).Case report.Clinical history, physical and laboratory findings, and magnetic resonance imaging studies of a patient with cervicothoracolumbar SEA and CSW.We report the case of a 15-year-old boy with cervicothoracolumbar SEA complicated with CSW and treated with conservative methods.In conclusion, CSW can be seen at the follow-up period of the SEA and the clinicians must be aware of this entity.