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Intrauterine growth restriction (IUGR) is an anomaly of fetal growth dynamics, which is mainly caused by alterations in the vascular remodeling of utero-placental arteries. With a prevalence of 10% of pregnancies, IUGR remains the leading cause of perinatal mortality. Doppler velocimetry is the common screening tool for IUGR but this imaging modality remains controversial. In this context, we evaluated...
Acoustic streaming effects are usually treated using perturbation theory by writing the field variables as perturbation expansions utilizing a small scale parameter and solving the ensuing equation systems. When conducting numerical simulations, this approach can help reducing the computational effort drastically. In most cases, the zero-order velocity is assumed to be zero, which is an applicable...
Photoacoustic (PA) imaging aims for the reconstruction of acoustic sources that originate in pulsed light absorption. While the speed of sound (SOS) in biological tissue is heterogeneous, standard reconstruction algorithms usually assume a constant SOS. This results in deformations of the reconstructed sources, which are referred to as aberration and can have a severe impact on the spatial resolution...
We have recently demonstrated the feasibility of vascular guided wave imaging (VGWI) in non-invasive estimation of bi-plane (i.e., longitudinal and transverse) transmural arterial Young's modulus (ELV, ETV) in tubular phantoms using phase velocity (cph) (Guo et al., ITEC 2016). In this study, we further compare the ETV estimated from the circumferential Lamb type (CLT) wave by VGWI with ETP from the...
New ultrasound imaging and therapeutic modalities may require transducer designs that are not easily facilitated by conventional design guidelines and analytical expressions. This motivates the investigation of numerical optimization methods that can include the effect of structural layers (e.g. bonding and electrodes), electrical loading, and more than one active piezoceramic layer in the design...
Air-coupled transducers are used to conduct fast non-contact inspections in NDT. Normally, the bandwidth of a conventional transducer can be enhanced, but with a cost to its sensitivity. However, low sensitivity is very disadvantageous in air-coupled NDT. This paper presents a methodology for improving the bandwidth of an air-coupled diaphragm transducer without sensitivity loss by connecting a number...
In the present work, nonlinearities in temperature compensating (TC) SAW devices are investigated. The materials used are LiNbO3-rot128YX as the substrate and Copper electrodes covered with a SiO2-layer as the compensating layer. In order to understand the role of these materials for the nonlinearities in such acoustic devices, a FEM simulation model in combination with a perturbation approach [1]...
Histotripsy with ultrasound is an emerging noninvasive therapeutic modality that uses cavitation to precisely destroy diseased soft tissue. Accurate simulations of histotripsy are needed for treatment planning and device design. These simulations are performed in the time-domain, span hundreds of wavelengths, and must handle strong shocks and discontinuities between materials, such as the brain and...
Histotripsy with ultrasound is an emerging noninvasive therapeutic modality that uses cavitation to precisely destroy diseased soft tissue. Accurate simulations of histotripsy are needed for treatment planning and device design. These simulations must model transient pressure fields, span hundreds of wavelengths, and must handle strong shocks and discontinuities between materials, such as the brain...
Tissue elasticity is an important parameter which relates to the pathological state of soft tissue. Fibrotic lesions or malignant tumors are known to be notoriously stiff compared to benign tissue. Shear wave elastography can provide a fully quantitative measure of lesion stiffness by estimating the speed at which acoustically induced shear waves propagate through the material. This speed is in turn...
Irregular patterns of microcalcifications in the breast may indicate a malignant cancer tumor. The gold standard for early detection is X-ray mammography. However, high density of connective tissue of the breast can limit detection. Improved suppression of the connective tissue can be achieved with ultrasound. However detecting the weak signals from microcalcifications in a highly echoic background...
Burst wave lithotripsy (BWL) is an experimental method to noninvasively fragment urinary calculi using low-frequency focused bursts of ultrasound. To optimize many of the acoustic parameters for this technology, it is necessary to understand the physical interactions between ultrasound bursts and stones. In this study, the interaction of elastic waves with model stones was simulated and experimentally...
A general purpose finite element model that yielded directly the nonlinear frequency response of the second harmonic generation in SAW IDT resonators was developed. The model enabled us to study the effects of the nonlinear material constants, voltage drive, duty factor, and IDT geometry on f-2f nonlinear interactions. Specifically we have applied our model to the study of nonlinear frequency response...
Photoacoustic (PA) imaging aims for the reconstruction of acoustic sources that originate in pulsed light absorption. While the speed of sound (SOS) in biological tissue is heterogeneous, standard reconstruction algorithms usually assume a constant SOS. This results in deformations of the reconstructed sources, which are referred to as aberration and can have a severe impact on the spatial resolution...
A new toolbox for the simulation of acoustic wave fields is described. The toolbox, USim, is designed to make an acoustic modeling of ultrasound propagation in tissues reliable and fast. The forward simulations of the wave field are based on the Born-Neumann single scattering approximation of the solution of Sturm-Liouville equation. The toolbox allows simulating the ultrasound wave propagation in...
In this paper an ultrasonic reflectometry approach to measure the thermal conductivity and temperature of a material by contact is presented. This device can be utilized for monitoring material properties during manufacturing, and robotic handling of objects. The sensor comprises an AlN piezoelectric ultrasonic transducer operating at GHz frequencies, situated on one side of a silicon chip. The transducer...
The estimation of Ultrasound-Contrast-Agent (UCA) kinetics from Dynamic Contrast-Enhanced Ultrasound (DCE-US) recordings has shown promise to localize prostatic malignancy. In a two-dimensional (2D) approach, UCA dispersion and velocity provide a characterization of the prostate (micro)vasculature with diagnostic value [1]. To this end, the UCA transport kinetics are modelled with strong assumptions...
Resonator based S0 Lamb wave mode in AlN thin films plate has drawn great attentions thanks to its high phase velocity up to 10 km/s and large electromechanical coupling coefficient (K2). Moreover, this structure allows operation at high temperature conditions. Although several significant research efforts are ongoing to enable AlN-based piezoelectric devices for high temperature applications, an...
Previous work has shown that the degree of anisotropy in tissue can be assessed using Acoustic Radiation Force Impulse (ARFI) imaging performed with a geometrically asymmetric excitation. In this work, we investigate the clinical relevance of mechanical anisotropy in Duchenne muscular dystrophy (DMD). Anisotropy assessment was performed using relative elasticity (RE) and relative viscosity (RV) parameters...
Contrast of echographic images has been highly improved by the injection of microbubbles, due to their nonlinear behavior. However, this contrast enhancement is limited by the nonlinear acoustic propagation in tissue. To overcome this drawback, sub and ultra-harmonic contrast imaging can be used, since only microbubbles can generate these components. Nonlinear modeling is a primordial step in the...
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