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Nowadays, pathologist« grade breast cancer histopathology slides by microscopes based on Nottingham as an international standard. The mitotic counting is one of the three scoring criteria in Nottingham standard for breast cancer grading based on histopathology slide image studies. Large number of non-mitosis organs, which exists in histopathology slide tissue, is one of the most important challenges...
This paper presents a method for automatic segmentation of mandibular canal from CBCT (cone beam CT) images based on 3D Active Appearance Models (AAM) and shape context registration. The proposed algorithm consists of two stages: Firstly, Shape Context based non-rigid surface registration of the manual segmented images is used to obtain the point correspondence between the given training cases. Subsequently,...
Diffusion weighted imaging (DWI) is a non-invasive method for investigating the brain white matter structure. It can be used to evaluate fiber bundles in the brain. However, clinical acquisitions are often low resolution. This paper proposes a method for improving the resolution using sparse representation. In this method a non-diffusion weighted image (bO) is utilized to learn the patches and then...
Simulation of human heart mitral valves is a challenging biomechanical problem due to its complex anatomical structure, material properties and time dependent loading conditions. This study presents a modeling and simulation of human mitral valve behavior considering the effects of material nonlinearity and Chordae tendineae rupture via a numerical analysis. Three-dimensional sized geometrical model...
We develop A computational finite element model to study microcirculation and drug delivery to tumors under drug bolus injection into the blood stream. The mathematical model is based on the fundamental laws of filtration and transport in biological tissues at the micro-scale level. The model consists of two separate regions. A network of vessels carrying blood flow (the capillaries), and the surrounding...
Thermal dose indicates the level of thermal lesion. During a thermal therapy, desired thermal dose distribution along a tissue can be obtained by proper manipulation of heat source. In this study, the inverse heat transfer problem is applied to estimate the external heat source in a living tissue for a desired thermal dose. The inverse method is the conjugate gradient method with the adjoint problem...
The objective of this work is modeling the interaction between pulsatile blood flow and arterial walls. We model blood flow in arteries as an incompressible viscous fluid with Newtonian rheology, confined by a poroelastic arterial wall modeled with the Biot equations. We propose loosely coupled solution strategy of the fluid-structure interaction problem, which allows solving the Navier-Stokes and...
The main goal of this study is to investigate the role of vascular graft thickness in wall stress gradient in anastomosis region. Atherosclerosis is a common heart disease causes high mortality rates every year. The gold standard treatment of atherosclerosis is replacing with autologous vein extracted from patient's body. Since proper autologous vein is limited, researchers have made efforts to achieve...
Spinal Cord Injury is one of the most important issues of medical society in the world. Problems that the disabled encounter after the accident are significant, namely pressure sores, bone mineral density loss, and disorders in circulation system. The proposed design is a new standing wheelchair that helps the disabled overcome these problems. Affordability and manufacturing problems still exist....
Porous nanocomposite scaffolds were fabricated by freeze casting method with composition of constant chitosan concentration (3 wt.%) blended with different percentages of (10, 20 and 50 wt.%) bioactive glass nanoparticles (BGNPs) which were synthesized by sol-gel method. Transmission Electron Microscopy (TEM) images proved that the size of synthesized BGNPs with formula of 64Si02.28Ca0.8P205 was lower...
Mesenchymal stem cells (MSCs) have the potential to differentiate to other cells and this feature makes it as an attractive source in tissue engineering. Mesenchymal stem cells are subjected to many mechanical stimuli in vivo such as an in vivo pressure loading and one of the cell respond to these stimuli is differentiation to cartilage or bone cell. One of the most significant ways for this goal...
In this study, an improved method of iterative independent component analysis (/ICA) on single-trial brain responses was employed to investigate neural mechanisms underlying inhibitory control deficits in adults with attention deficit / hyperactivity disorder (ADHD). Specially recorded data during a continuous performance task from 10 ADHD and 11 healthy control subjects were analyzed. Behavioral...
Sleep apnea is a frequent disorder where breathing process is ceased during the sleep and it is found to be a root for cardiovascular problems. In this study, we tend to detect this syndrome solely from nocturnal ECG records. The proposed method is based on higher order spectrum of heart rate variability (HRV) and ECG-derived respiratory (EDR) signals, which extracted from ECG signal. In order to...
Blood Pressure (BP) measurement during exercise test is of great importance. Due to the low accuracy of measuring BP using cuff and barometer during exercise and limitations in the continuous measurements because of the vessel crush, it will be of great advantage to obtain systolic and diastolic BP values in a cuff-less approach. This could be achieved by using extracted features and characteristics...
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