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Welcome to the 42nd Computing in Cardiology Proceedings. This was the second time, after Lyon 2005, that the Computing in Cardiology community meet in France, a country with a long tradition of engineering applied to cardiology. The Board of Directors was delighted when Olivier Meste and his colleagues from University of Nice Sophia Antipolis volunteered to host this year's meeting. They prepared...
A typical feature of sinoatrial node (SAN) pacemaker cells is the presence of an ionic current, named ‘funny current’, If, that activates upon hyperpolarization. We aimed to: 1) test the impact of different mathematical models of If (Maltsev-Lakatta and Severi-DiFrancesco) in real cells by using the Dynamic Clamp (DC) technique; 2) adapt the DC protocol to adequately simulate a shift of the If activation...
Left atrium (LA) is a principal site of thrombus formation inducing thromboembolic events, which have been associated with LA low flow velocities. Recent developments in magnetic resonance imaging (MRI) 4D flow analysis enable a non-invasive visualization of LA flow patterns. Our main objective was to investigate modifications of the main vortices in the LA with regards to LA functional indices in...
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease characterized by an unexplained thickening of the heart ventricles. It is the first cause of sudden cardiac death in young adults. No reliable biomarkers for risk assessment have been presented so far, but the electrocardiograms of HCM patients are often abnormal due to structural and electrical abnormalities. The goal of our study...
Currently, clinical assessment of mitral regurgitation (MR) makes the use of 2D color Doppler imaging for the estimation of the vena contracta (VC) and of the effective regurgitant orifice area (EROA)‥Since the anatomic regurgitant orifice (ARO) has a 3D shape and it's not circular, it cannot be accurately represented by these 2D parameters. We developed a novel semiautomated method for 3D ARO segmentation...
The current validation of non-invasive blood pressure (NIBP) device is performed under resting condition. However, NIBPs are often used without giving much consideration about the measurement conditions. This study aimed to provide scientific data on the use of BP devices in unstable conditions.
We assessed the effects of cold face test (CFT) and active orthostatic test (AOT) on the RR intervals (RR), systolic pressure (SP) and maximal amplitude of arterial pressure first derivative (dmAP) time series of 25 healthy volunteers, and the instantaneous dynamics of their low-frequency powers (LFRR, LFSP and LFdmAP), to characterize their time course, and compare their performance as sympathetic...
Seismocardiography (SCG) is the measurement of vibrations in the sternum caused by the beating of the heart. Precise cardiac mechanical timings that can only be obtained from SCG are critically dependent on accurate identification of fiducial points.
Dialysis patients often suffer from cardiovascular diseases, motivating the use of continuous monitoring of cardiac activity in clinical routine. Cardiac pressure pulses propagate through the vascular system and enter the extracorporeal blood circuit of a dialysis machine, where the pulses are captured by pressure sensors. The cardiac pulses are obscured by the much stronger pressure pulses originating...
In 28 healthy volunteers, we assessed the effects of 5-min maneuvers that provoke different sympathetic and respiratory activities (supine rest (SR), controlled breathing (CB), standing (S) and exercise (E)) on the instantaneous low (LF) and high frequency (HF) powers of pulse (LFPP, HFPP), systolic (LFSP, HFSP), and diastolic pressures (LFDP, HFDP), to associate physiological correlates to LFPP and...
In this research Seismocardiogram (SCG) signal was used for timing the proximal pulse while pulse-plethysmogram (PPG) was used for timing the dorsal pulse for computing pulse transit time (PTT). Lower body negative pressure (LBNP) was applied for gradually reducing the pulse pressure in 9 subjects. The correlation between the pulse pressure and PTT derived using SCG was studied. It was determined...
This study aimed to assess an early classification of paroxysmal and persistent atrial fibrillation (AF) episodes by means of the surface ECG on a heterogeneous cohort of patients (in terms of antiarrhythmic treatment and state of evolution of the arrhythmia), which is similar to the context that clinicians find at tertiary centres in their daily work. 129 consecutive unselected patients suffering...
Catheter ablation is an effective therapy to treat atrial fibrillation (AF) whenever the proper atrial regions are targeted. Electro-anatomical mapping is commonly used for that purpose, thus facilitating the location of ablation targets. However, reliable mappings acquisition depends on an accurate detection of local activation waves (LAWs) from atrial electrograms (EGMs). This is currently a handmade...
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