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Provides an abstract for each of the plenary presentations and a brief professional biography of each presenter. The complete presentations were not made available for publication as part of the conference proceedings.
Presents the introductory welcome message from the conference proceedings. May include the conference officers' congratulations to all involved with the conference event and publication of the proceedings record.
This work presents an idealized geometric model of the lymph node (LN) consisting of a set of 'elementary' macroscopic structures such as subcapsular sinus, trabecular sinuses with a special focus on fibroblastic reticular cells (FRC) network. An experimental data driven computational algorithm has been developed to reconstruct the macroscopic structure of FRC network based on high-resolution confocal...
Rapidly evolving pathogens, such as RNA viruses exploit the high mutation rate to avoid or escape host immune response. Despite a random mutation process, the relatively small size of their genomes imposes evolutionary constraints. Viral evolution hence is characterized by highly connected mutations that arise within the same genome through a random sequential process. In this abstract we present...
Nowadays non-cellulosic, β-glucans from the different source are intensively investigated due to the fact that these biological polymers are recognized as potent immunological stimulators for the mammal's immune system. Dendritic cells are the most important antigen presenting cells for activating naive T cells. The research goals of the recent investigation were to determine how the different molecular...
Packing equal disks in a unit square is a classical geometrical problem which arises in many industrial and scientific fields. Finding optimal solutions has been proved to be NPhard, therefore, only local optimal solutions can be identified. We tackle this problem by means of the optimization Immune Algorithm (optIA), which has been proved to be among the best derivativefree optimization algorithms...
Transitional (TR) B cells are immature B cells that have migrated from the bone marrow to peripheral lymphoid organs, but can still undergo selection against autoreactivity. TR cells that survive selection eventually develop into mature naïve B cells (CD27-IgD+, NA). Upon exposure to antigen, NA cells may become IgM memory (CD27+IgD+, MM) or "classical", classswitched memory (CD27+IgD-,...
Calcium dynamics lie at the heart of many adaptive cellular signals and are thus tightly controlled. While the importance of calcium in immune cell modulation has long been known, it is only in recent studies that immune cell differentiation, maturation and response to T cell receptor signaling, have been linked to the dynamics of calcium. Postantigen binding calcium signaling is controlled by the...
The development of cloud computing brings convenience to our lives due to high efficiency, usability, accessibility and affordability. But the cloud data privacy faces severe challenges. Although Negative survey, which is spired by Artificial Immune System (AIS), can protect users’ privacy data with high efficiency and degree of privacy protection, its accuracy is influenced by the number of client...
We present PareDA (ParetoDesignAutomation), a composite automated methodology for the simulation-based multi-scenario multi-objective optimization of analog circuits and thin-film cell devices, relying on randomized algorithms, both domain and constraints sensitivity analysis, epsilon-dominance and global robustness analysis. We test PareDA algorithm on the designing problem of a three stage operational...
Traditional clonal selection algorithm gives us some inspiration for many applications, but in the medical image enhancement application we found some defects of this algorithm. So we improved the clonal selection algorithm in three ways. First, we designed the real coding of the MRI brain image, instead of binary coding. Second, we added the mutation distance to control the mutation progress and...
Genome wide association studies (GWAS) have tended to focus on the association between single nucleotide polymorphisms (SNPs) and human diseases by looking at individual variants. However, complex diseases are more likely due to certain combinations of genetic variants rather than single variants acting independently in an additive fashion. As such, the interactions between multiple SNPs, epistatic...
The Negative Selection Algorithm is an anomaly detection technique, inspired by the self-nonself discrimination behavior observed in the Biological Immune Systems. The most controversial problem of the negative selection algorithm is its inherent limitation in detecting foreign patterns as anomalies. This limitation causes high false positive rate in anomaly detection systems which are based on the...
As the first cancer-causing human virus identified, Epstein-Barr virus (EBV) has been implicated in the development of a wide range of B cell lymphoproliferative disorders, a subset of T/NK cell lymphomas, and post-transplant lymphoproliferative disorders. We made use of the immunological data on EBV available through publications, technical reports, and databases and constructed Epstein-Barr virus...
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