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We explored a possible new method for prediction of activating mutations in cancer-related proteins. This method is based on elucidation of flexibility of proteins associated in activating complexes. Based on the theory of intermediate binding complexes, the binding process is not only related to the three-dimensional structure of proteins, but also to the four-dimensional set of possible conformations...
For numerical simulations in a sphere, we have recently proposed a new spherical grid system called Yin-Yang-Zhong grid. The Yin-Yang-Zhong grid is composed of three components — Yin, Yang, and Zhong — that are combined to cover a spherical region with partial overlaps on their borders. Mutual interpolations are applied to sew the components together, following the overset grid methodology. We review...
This work presents an alternative assessment of climate projections using FACTS (Bastien and Gay, 2016), based on possible future emissions pathways related to the Intended National Determined Contributions presented in 2015 as part of the Paris Agreement on climate change. Moreover it proposes emission reductions in order to stabilize the climate to the desired levels proposed by the international...
A practical application of multi-physics simulations was presented. In order to analyse thermal stability of MEMS micro scanner, multi-physics simulation procedure was proposed and then verified by comparing the simulated results to the measured data. The proposed procedure started from defining simulation parameters and was verified stepwise by comparing the interim results with the related experimental...
Managing risks in supply chains is challenging for most companies, given the globalisation process which is strengthening the production constraints and also introducing more procurements risks. This is especially difficult for smaller companies because they generally lack resources to develop a specific expertise or buy expensive tools. Our research aims at addressing those issues by proposing an...
In almost all industrial fields such as automobile and aerospace industries, in recent years, the precisely complicated shapes of channel and frame parts are increasingly applied. To fabricate these parts, the U-bending process being a common sheet-metal forming process is widely employed. However, the asymmetrical U-bending process lacks researches. Therefore, in this study, the effects of asymmetrical...
This work presents a new approach for assessing the climate system and for stabilizing the temperature and other climate parameters. FACTS, as we call it, is a fuzzy inference system that overview certain climate state, and is able to generate the CO2 emissions reduction needed to implement in order to stabilize the temperature. FACTS was constructed using a neural network optimization process along...
It is becoming increasingly important to make possible constitutive modelling and simulation of material behaviour for the prediction of possible failures in material. This can allow to the optimization of design of highly loaded engineering components. In order to achieve that goal, material parameters should be accurately determined for the chosen material model. The major step in material parameters...
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