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Arranging microparticles into desired pattern is of particular importance for many applications in the field of micro-electronics-mechanical system, regenerative medicine, tissue engineering and composite fabricating. A variety of techniques for patterning microparticles on the substrate have been developed in recent years based on optic, magnetic and electric field. However, each above mentioned...
Tumor growth requires formation of new angiogenic vessels, which differ in their morphology from those of healthy tissue. These vascular abnormalities result in altered blood flow dynamics, which can be assessed by dynamic contrast-enhanced ultrasound (DCE-US). Two distinct approaches are typically employed in DCE-US following an intravenous injection of ultrasound contrast agent: assessment of perfusion...
Cardiovascular disease, including atherosclerosis and critical limb ischemia, affects millions of people worldwide. There is a clinical need to base treatment decisions on quantitative analysis of the plaque composition. However, no reliable clinical methods to quantify the mechanical properties of plaque components and detect plaque vulnerability currently exist, particularly for coronary disease...
I describe recent progress in machine learning in medical ultrasound imaging. At a high level, the two technologies appear to be well-matched as the former attempts to make sense of complex patterns, and the latter can generate images of complex acoustic patterns. Thus, the general challenge to the image analysis practitioner is to design machine learning architectures that model the patterns in real...
To prevent unauthorized access to ICs, encryption can be enabled via extremely small and practically invisible microscale chips that are embedded inside the packaging of ICs. The authors lately demonstrated an acoustic power link based on AlN HBAR-like structures operating at 500 MHz [1]. Enormous acoustic losses introduced by air at such large frequencies necessitate tight coupling between the transducers...
Flow cytometer plays a key role in cell sorting and analysis. For a higher detection precision, sheath flow is adopted to avoid the turbulent or vortex effect when the cell flowing through a capillary tube during the cell counting in many commercial cytometers. This method works well when the low flow velocity is relatively low. However, in order to have a higher analysis efficiency for clinical laboratories,...
Accurate diagnosis of non-alcoholic steatohepatitis (NASH) is a critical issue in current clinical practice. Non-invasive diagnosis of NASH can be achieved by quantitative ultrasound (QUS), which requires a detailed understanding tissue-specific acoustic microstructure at cellular scale (i.e., 10 μm). Therefore, QUS methods would benefit from the knowledge of the acoustic properties of organelles...
Ultrasonic guided wave inspection has been in use for more than two decades. Its main advantage is that large sections of pipes can rapidly be screened. However, large area coverage comes at the cost of reduced resolution. Higher resolution can be achieved at higher frequencies-thickness products (> 300 kHz∗mm in steel), where more wave modes are excited; however, this makes the received signals...
Elastic properties of the ocular tissues are significantly affected by intraocular pressure (IOP) in the eye. For example, the speed of the elastic wave in the cornea dramatically increases with IOP. In our previous studies using ultrasound shear wave imaging we demonstrated that, for the lens, the increase in IOP does not result significant changes in the wave velocity. Compared with ultrasound imaging,...
One of the primary motivations for using ultrasound reflectometry for fingerprint imaging is the promise of increased spoof resistance over conventional optical or capacitive sensing approaches due to the ability for ultrasound to determine the elastic impedance of the imaged material. A fake 3D printed plastic finger can therefore be easily distinguished from a real finger. However, ultrasonic sensors...
Piezoelectric ultrasonic motors (PUMs) are based on the concept of driving the runner by a mechanical vibration excited on the stator via the converse piezoelectric effect. They exhibit merits of small size, simple structure, quick response, high accuracy and resolution, self-locking when power off and a lack of electromagnetic radiation. The linear PUMs become the research focus in recent years as...
Rodents are used extensively in research to study disease and evaluate drugs. Preclinical imaging systems allow for non-invasive assessments of animals. High frequency ultrasound systems have emerged over the last 15 years as valuable tools for evaluating numerous diseases and organs. When compared against other anatomical imaging systems, such as MRI and CT, ultrasound is the most cost effective,...
Multi-frequency transducers may have a number of emerging applications including multi-scale imaging, superharmonc contrast imaging and imaging-therapy applications. For imaging-therapy applications low-frequencies are typically needed for therapeutic heating or contrast agent destruction, while higher-frequencies are required for high-resolution imaging. However, development of these multi-frequency...
Laser Induced Phased Arrays (LIPAs) use post processing to focus and steer the generated ultrasonic beam, synthesizing a phased array. Their principle is based on laser ultrasonics where lasers are used to generate and detect ultrasound. The technique is broadband, non-contact, and couplant free, making LIPAs suitable for large stand-off distances, inspection of components of complex geometries and...
Electromagnetic [1] and acoustic [2] metamaterials that exhibit linear dispersion at a nonzero frequency and a wave vector (k) of zero, leading to a conical dispersion surface or so-called Dirac cone dispersion, have been demonstrated recently. These materials display unusual behavior associated with the occurrence of a finite group velocity at k = 0, leading to a wave which propagates with a uniform...
Automated tow placement has become a widely-used fabrication technique, especially for large aerospace structures. Robotic heads lay down strips of pre-impregnated fiber (called tows) along programmed paths. While the intention is to lay adjacent tows abutted to one another, occasionally a tow is placed leaving a non-zero gap between it and the previously-placed tow. In order to preserve the intended...
Harmonic imaging techniques are widely used in B-mode abdominal imaging and motion tracking in shear wave elasticity imaging (SWEI) to reduce clutter and improve data quality. Harmonic imaging can be both signal-to-noise (SNR) and penetration depth (PD) limited, resulting in decreased diagnostic utility. This work evaluates B-mode harmonic imaging and SWEI harmonic tracking data quality between imaging...
Blood clotting, a process to avoid bleeding, involves vasoconstriction, platelet plug build-up, coagulation, clot retraction and fibrinolysis. During coagulation, blood changes from liquid to gel, and the clot viscoelastic properties continue modifying until fibrinolysis. Tests to analyze bleeding disorders and anticoagulant therapy include clot-based assays, to detect the end-point of fibrin network...
In conventional ultrasonic monitoring of high intensity focused ultrasound (HIFU) treatment, it has been difficult to track the target region when the tissue to be treated deviates from the imaging plane along the elevation axis of the 1-D probe. A 2-D phased array probe providing 3-D imaging capability requires a large number of elements and it is very expensive to build a system to drive all channels...
Over the last decade, clinical studies show a strong interest for real-time 3D imaging. This calls for ultrasound probes with high-element-count 2D matrix transducer array, interfaced to an imaging system using an in-probe Application Specific Integrated Circuit (ASIC) that takes care of element selection, signal amplification, sub-array beamforming, etc. Since the ASIC is based on silicon and is...
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