The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum glycoprotein biomarker, alpha-fetoprotein (AFP) Carbohydrate binding proteins, such as lectins, can be used as diagnostic indicators for monitoring glycosylation changes during disease...
A novel non-lithographic, contamination-free technique for the fabrication of graphene field effect transistors (GFET) is presented. The GFET was modified with C reactive protein aptamer. Iron nanoparticles were immobilized on the GFET channel surface by using an aptamer-target protein (CRP)-aptamer sandwich method. Bistability signal was obtained by backgate voltage up/down sweeping. The bistability...
This paper reports a new class of biosensors based on composite nanomaterial thin film. The composite nanomaterial film is synthesized using a simple vacuum filtration method. Using composite nanomaterial film, we can not only simplify the positioning and integration fabrication process of nanoscale materials into a functional device, but also enhance the sensing surface area significantly, which...
In this paper, a simple and robust sensing assay platform for detection of biological materials is reported. The fluorescence based sensing platform benefits from the combined use of our novel dye-doped nanoparticle tags and nanoporous high surface area (~1,400 m2/g) films to achieve high intrinsic signal amplification. The dye-doped nanoparticles are synthesized from poly-methylsilsesquioxane (PMSSQ)...
Gold - poly(dimethylsiloxane) (Au - PDMS) nanocomposite freestanding films were prepared and used to study the binding of Human Serum Albumin (HSA) to polyclonal anti-HSA. A new method of synthesis was developed for sensing application when most of the gold nanoparticles have to be localized in the surface layer. The localized surface plasmon resonance band in gold nanoparticles is used to monitor...
This study was designed to develop and evaluate a chitosan-collagen-soybean phosphatidylcholine (SPC) complex film impregnated with mitomycin C (MMC)-PLA- nanoparticles for treatment of hepatocellular carcinoma in mice. MMC-PLA-nanoparticles were prepared by a reverse micelle-solvent evaporation method. PLA-MMC-nanoparticles were dispersed throughout the film. SEM, ATR-FTIR were used to character...
A novel optical biosensor with gold surface bound silver nanoparticles has been constructed for detection of bio-molecules like antigen, antibody protein and DNA plasmid, which exhibited distinct optical properties of localized surface plasmon resonance (LSPR). The silver colloidal nanoparticles were prepared by using sodium borohydride reduction of silver nitrate and characterized by using UV-vis...
This paper reports a rapid, simple and direct method for the synthesis of gold nanoparticles (AuNPs) in polypyrrole (PPy) film, which provides a biocompatible matrix for the strong adsorption of antibodies. The electrochemical synthesis of AuNPs/PPy composite on gold or carbon electrode occurs within 20 minutes, and does not involve addition of any nanoparticles or reducing agent. This method is compatible...
We are developing a novel reporter for proximity assays based on enhanced lanthanide luminescence promoted by metal nanoparticles. This method should provide high on/off ratios using photostable labels.
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.