Search results for: Maria X. Maldonado-Gomez

Items from 1 to 6 out of 6 results

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To engraft or not to engraft: an ecological framework for gut microbiome modulation with live microbes

Jens Walter, María X Maldonado-Gómez, Inés Martínez

Current Opinion in Biotechnology > 2018 > 49 > C > 129-139

Strategies aimed at modulating the gut microbiota by using live microbes range from single strains (probiotics or live biotherapeutics) to whole non-defined fecal transplants. Although often clinically efficacious, our understanding on how microbial-based strategies modulate gut microbiome composition and function is vastly incomplete. In this review, we present a framework based on ecological theory...

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Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome

María X. Maldonado-Gómez, Inés Martínez, Francesca Bottacini, Amy O’Callaghan, more

Cell Host & Microbe > 2016 > 20 > 4 > 515-526

Live bacteria (such as probiotics) have long been used to modulate gut microbiota and human physiology, but their colonization is mostly transient. Conceptual understanding of the ecological principles as they apply to exogenously introduced microbes in gut ecosystems is lacking. We find that, when orally administered to humans, Bifidobacterium longum AH1206 stably persists in the gut of 30% of individuals...

article

The Gut Microbiota of Rural Papua New Guineans: Composition, Diversity Patterns, and Ecological Processes

Inés Martínez, James C. Stegen, Maria X. Maldonado-Gómez, A. Murat Eren, more

Cell Reports > 2015 > 11 > 4 > 527-538

Although recent research revealed an impact of westernization on diversity and composition of the human gut microbiota, the exact consequences on metacommunity characteristics are insufficiently understood, and the underlying ecological mechanisms have not been elucidated. Here, we have compared the fecal microbiota of adults from two non-industrialized regions in Papua New Guinea (PNG) with that...

article

Adherence inhibition of enteric pathogens to epithelial cells by bovine colostrum fractions

Maria X. Maldonado-Gomez, Hyeyoung Lee, Daniela Barile, Mei Lu, more

International Dairy Journal > 2015 > 40 > Complete > 24-32

To initiate colonization, microbial pathogens express adhesins that recognize and adhere to host tissue cells. One strategy for inhibiting adherence relies on the presence of molecules that mimic epithelial receptor sites. In this study, in vitro experiments using HEp-2 cells were performed to assess the anti-adherence properties of bovine colostrum fractions against enteropathogenic Escherichia coli,...

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In vitro digestion and fermentation of 5-formyl-aminosailcylate-inulin: A potential prodrug of 5-aminosalicylic acid

Annette L. Hartzell, María X. Maldonado-Gómez, Junyi Yang, Robert W. Hutkins, more

Bioactive Carbohydrates and Dietary Fibre > 2013 > 2 > 1 > 8-14

Many carbohydrate polymers that have been used as carriers for colon-targeted drugs have shown benefits against colonic diseases. The objectives of this project were to (1) synthesize a derivative of 5-aminosalicylic acid (5-ASA), a drug used to treat inflammatory bowel disease, containing inulin, a carbohydrate polymer that has shown benefits against inflammatory bowel disease; (2) quantify the release...

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Synthesis and in vitro digestion and fermentation of acylated inulin

Annette L. Hartzell, María X. Maldonado-Gómez, Robert W. Hutkins, Devin J. Rose

Bioactive Carbohydrates and Dietary Fibre > 2013 > 1 > 1 > 81-88

The objective of this project was to develop a method for the synthesis of acetylated, propionylated, and butyrylated inulins as designer dietary fibers for enhanced gut health. High purity (HP) inulin was acylated with acetic anhydride, propionic anhydride, or butyric anhydride. Degrees of substitution [mol short chain fatty acid (SCFA)/mol fructosyl equivalents] were 0.313±0.013, 0.152±0.005, and...

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Search results for: Maria X. Maldonado-Gomez

To engraft or not to engraft: an ecological framework for gut microbiome modulation with live microbes

Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome

The Gut Microbiota of Rural Papua New Guineans: Composition, Diversity Patterns, and Ecological Processes

Adherence inhibition of enteric pathogens to epithelial cells by bovine colostrum fractions

In vitro digestion and fermentation of 5-formyl-aminosailcylate-inulin: A potential prodrug of 5-aminosalicylic acid

Synthesis and in vitro digestion and fermentation of acylated inulin

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