Search results for: Russell E. Lewis

Items from 1 to 20 out of 52 results

article

Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists

Erin K. McCreary, Matthew R. Davis, Navaneeth Narayanan, David R. Andes, more

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 43 > 10 > 1043 - 1050

Triazole antifungals (i.e., fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) are commonly used in clinical practice to prevent or treat invasive fungal infections. Most triazole antifungals require therapeutic drug monitoring (TDM) due to highly variable pharmacokinetics, known drug interactions, and established relationships between exposure and response. On behalf of the...

article

Saprochaete clavata infections in patients undergoing treatment for haematological malignancies: A report of a monocentric outbreak and review of the literature

Marta Stanzani, Monica Cricca, Claudia Sassi, Emanuele Sutto, more

Mycoses > 62 > 12 > 1100 - 1107

Saprochaete clavata is a rare cause of fungaemia with deep organ involvement in patients with haematological malignancies with reported mortality rates of 60%‐80%. We describe four cases of S clavata infection in a haematology unit over several months that were treated with voriconazole‐based regimens. We also review the literature on factors that could contribute to earlier recognition and effective...

article

Comparative serum bactericidal activity of meropenem-based combination regimens against extended-spectrum beta-lactamase and KPC-producing Klebsiella pneumoniae

Paolo Gaibani, Donatella Lombardo, Michele Bartoletti, Simone Ambretti, more

European Journal of Clinical Microbiology & Infectious Diseases > 2019 > 38 > 10 > 1925-1931

Combination therapies are frequently used in the treatment of multidrug-resistant Klebsiella pneumoniae infection without consensus regarding which combination is the most effective. We compared bactericidal titres from sera collected from critically ill patients receiving meropenem plus tigecycline (n = 5), meropenem plus colistin (n = 5), or meropenem, colistin and tigecycline (n = 5) against K. pneumoniae...

article

Transcriptional profiles of pulmonary innate immune responses to isogenic antibiotic‐susceptible and multidrug‐resistant Pseudomonas aeruginosa

Vincent H. Tam, Cynthia Pérez, Kimberly R. Ledesma, Russell E. Lewis

Microbiology and Immunology > 62 > 4 > 291 - 294

The virulence of an isogenic pair of Pseudomonas aeruginosa strains was studied under similar experimental conditions in two animal infection models. The time to death was significantly longer for the multidrug resistant (MDR) than the wild‐type strain. The transcriptional profiles of 84 innate immune response genes in the lungs of immune competent Balb/C mice were further compared. Significantly...

article

Febrile events in acute lymphoblastic leukemia: a prospective observational multicentric SEIFEM study (SEIFEM-2012/B ALL)

Roberta Di Blasi, Chiara Cattaneo, Russell E. Lewis, Mario Tumbarello, more

Annals of Hematology > 2018 > 97 > 5 > 791-798

The purpose of the present study is to estimate the current incidence of febrile events (FEs) and infectious episodes in acute lymphoblastic leukemia (ALL) and evaluate the outcome. We analyzed data on all FEs in a cohort of patients affected by ALL admitted to 20 Italian hematologic centers during 21 months of observation from April 1, 2012 to December 31, 2013. Data about treatment phase, steroids,...

article

Successful treatment of bilateral endogenous Fusarium solani endophthalmitis in a patient with acute lymphocytic leukaemia

Ilaria Rizzello, Fausto Castagnetti, Pier Giorgio Toschi, Patrizia Bertaccini, more

Mycoses > 61 > 1 > 53 - 60

Fusarium spp. are an uncommon cause of fungaemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we describe a patient with acute lymphoblastic leukaemia and a prior history of extensive corticosteroid exposure who developed disseminated Fusarium solani infection following chemotherapy despite posaconazole prophylaxis. She was successfully treated...

article

In vitro interaction of ceftazidime–avibactam in combination with different antimicrobials against KPC-producing Klebsiella pneumoniae clinical isolates

Paolo Gaibani, Russell E. Lewis, Silvia L. Volpe, Maddalena Giannella, more

International Journal of Infectious Diseases > 2017 > 65 > C > 1-3

Combination therapy has been recommended when using ceftazidime–avibactam (CAZ–AVI) for the treatment of KPC-producing Klebsiella pneumoniae (KPC-Kp), but the optimal combination is unknown. Six common antimicrobial agents (ertapenem, imipenem, meropenem, gentamicin, tigecycline, and ciprofloxacin) were evaluated for synergy with the recently approved cephalosporin–β-lactamase inhibitor combination...

article

Risk factors for recurrent carbapenem resistant Klebsiella pneumoniae bloodstream infection: a prospective cohort study

Maddalena Giannella, Elena Graziano, Lorenzo Marconi, Nicolo Girometti, more

European Journal of Clinical Microbiology & Infectious Diseases > 2017 > 36 > 10 > 1965-1970

To assess risk factors for recurrent carbapenem-resistant Klebsiella pneumoniae bloodstream-infection (CR-KP BSI), we performed a prospective observational cohort study of all consecutive adult patients cured of a CR-KP BSI at our hospital over a six-year period (June 2010 to June 2016). Maximum follow-up per patient was 180 days from the index blood cultures (BCs). Recurrent CR-KP BSI was defined...

article

Liver transplantation is associated with good clinical outcome in patients with active tuberculosis and acute liver failure due to anti‐tubercular treatment

Michele Bartoletti, Giulia Martelli, Sara Tedeschi, Mariacristina Morelli, more

Transplant Infectious Disease > 19 > 2 > n/a - n/a

Background Active tuberculosis (TB) is commonly considered a contraindication for liver transplantation (LT). However, in patients with TB who develop acute liver failure (ALF) due to toxicity induced by anti‐tubercular treatment (ATT), LT could be the only opportunity for treatment. The aim of this study was to evaluate the feasibility of LT in this scenario. Methods We described 2 cases and comprehensively...

article

Radiologic findings of Fusarium pneumonia in neutropenic patients

Claudia Sassi, Marta Stanzani, Russell E. Lewis, Nicola Vianelli, more

Mycoses > 60 > 2 > 73 - 78

In neutropenic patients, lungs are involved in 50%–80% of cases of fusariosis, but imaging of pulmonary fusariosis has been previously described as indistinguishable from other invasive mould diseases. Our attempt was to identify a radiological pattern that may distinguish pulmonary fusariosis from other mould diseases. We examined the CT findings of nine neutropenic haematology patients with invasive...

article

Risk factors for infections in myelofibrosis: role of disease status and treatment. A multicenter study of 507 patients

Nicola Polverelli, Massimo Breccia, Giulia Benevolo, Bruno Martino, more

American Journal of Hematology > 92 > 1 > 37 - 41

Although infectious complications represent a relevant cause of morbidity and mortality in patients with myelofibrosis (MF), little is known about their incidence, outcome and risk factors. We retrospectively evaluated a cohort of 507 MF patients, diagnosed between 1980 and 2014 in five Italian hematology centers, to define the epidemiology of infections and describe the impact of ruxolitinib (RUX)...

chapter

Fungal Drug Resistance and Pharmacologic Considerations of Dosing Newer Antifungal Therapies

Russell E. Lewis, David S. Perlin

Current Clinical Oncology > Principles and Practice of Cancer Infectious Diseases > Major Etiologic Agents > 317-329

Recent advances in hematopoietic cell transplantation and a broadening array of salvage chemotherapy options have extended the survival of patients with hematological cancers, but can result in prolonged periods of immunosuppression and susceptibility to invasive fungal infections. Among these high-risk patient populations, systemic antifungal therapy is administered episodically or sometimes continuously...

chapter

Polyene Antifungal Agents

Russell E. Lewis

Aspergillosis: from diagnosis to prevention > Introduction > 281-305

Polyene antifungals have been the cornerstone treatment for invasive aspergillosis for over 40 years. Whilst new treatment options have somewhat changed their role, lipid-associated amphotericin B regimens remain important therapeutic options for aspergillosis due to their broad-spectrum of activity and limited cross-resistance with triazole antifungals. Recent studies have demonstrated the importance...

article

Improved Radiographic Imaging of Invasive Fungal Disease: The Cornerstone to Antifungal Stewardship in the Hematology Units?

Marta Stanzani, Claudia Sassi, Giuseppe Battista, Michele Cavo, more

Current Fungal Infection Reports > 2016 > 10 > 2 > 78-86

Empirical or fever-driven antifungal treatment strategies are widely recognized to result in overtreatment of patients and excessive cost. As a result, diagnostic-driven approaches for managing invasive fungal diseases (IFDs) in hematology units have been proposed that rely on early non-specific radiologic findings frequent testing with non-culture-based biomarkers (e.g., galactomannan, PCR) as a...

article

Computerized tomographic pulmonary angiography discriminates invasive mould disease of the lung from lymphoma

Claudia Sassi, Marta Stanzani, Russell E. Lewis

British Journal of Haematology > 169 > 4 > 462 - 462

article

Epidemiology and outcomes of bloodstream infection in patients with cirrhosis

Michele Bartoletti, Maddalena Giannella, Paolo Caraceni, Marco Domenicali, more

Journal of Hepatology > 2014 > 61 > 1 > 51-58

Bloodstream infections (BSIs) in cirrhotic patients are 10-fold more common than in non-cirrhotic patients and increasingly caused by resistant pathogens. We examined 162 BSI episodes in cirrhotic patients to describe the etiology and risk factors for 30-day mortality.We retrospectively analyzed all consecutive BSIs in patients with liver cirrhosis at our 1350-bed teaching hospital (January 2008 to...

article

Carbapenem‐resistant Klebsiella pneumoniae colonization at liver transplantation: A management challenge

Maddalena Giannella, Maria Cristina Morelli, Francesco Cristini, Giorgio Ercolani, more

Liver Transplantation > 20 > 5 > 631 - 633

article

Risk factors for early mortality in haematological malignancy patients with pulmonary mucormycosis

Russell E. Lewis, Sarah P. Georgiadou, Fotis Sampsonas, George Chamilos, more

Mycoses > 57 > 1 > 49 - 55

Pulmonary mucormycosis (PM) is a life‐threatening opportunistic mycosis with a variable clinical evolution and few prognostic markers for outcome assessment. Several clinical risk factors for poor outcome present at the diagnosis of PM were analyzed in 75 consecutive hematology patients from 2000–2012. Significant variables (P < 0.1) were entered into a multivariate Cox‐proportional hazard regression...

article

Epidemiology and sites of involvement of invasive fungal infections in patients with haematological malignancies: a 20‐year autopsy study

Russell E. Lewis, Lizebeth Cahyame‐Zuniga, Konstantinos Leventakos, Georgios Chamilos, more

Mycoses > 56 > 6 > 638 - 645

Autopsy studies remain an essential tool for understanding the patterns of fungal disease not detected ante mortem with current diagnostic approaches. We collected data concerning the microbiological trends, patient clinical characteristics and sites of involvement for invasive fungal infections (IFIs) identified at autopsy in a single large cancer treatment centre over a 20‐year period (1989–2008)...

article

Routine use of a real-time polymerase chain reaction method for detection of bloodstream infections in neutropaenic patients

Michela Paolucci, Marta Stanzani, Fraia Melchionda, Giulia Tolomelli, more

Diagnostic Microbiology & Infectious Disease > 2013 > 75 > 2 > 130-134

We examined the performance of a real-time polymerase chain reaction (PCR) test (SeptiFast) for early detection of bloodstream infection in febrile neutropaenic patients. Blood samples from 201 patients were screened for pathogens by blood culture and by PCR on the first day of fever. PCR results were available earlier (median 3 days for bacteria, 5 days fungal pathogens; P ≤ 0.01). The sensitivity...

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INFONA - science communication portal

Search results for: Russell E. Lewis

Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists

Saprochaete clavata infections in patients undergoing treatment for haematological malignancies: A report of a monocentric outbreak and review of the literature

Comparative serum bactericidal activity of meropenem-based combination regimens against extended-spectrum beta-lactamase and KPC-producing Klebsiella pneumoniae

Transcriptional profiles of pulmonary innate immune responses to isogenic antibiotic‐susceptible and multidrug‐resistant Pseudomonas aeruginosa

Febrile events in acute lymphoblastic leukemia: a prospective observational multicentric SEIFEM study (SEIFEM-2012/B ALL)

Successful treatment of bilateral endogenous Fusarium solani endophthalmitis in a patient with acute lymphocytic leukaemia

In vitro interaction of ceftazidime–avibactam in combination with different antimicrobials against KPC-producing Klebsiella pneumoniae clinical isolates

Risk factors for recurrent carbapenem resistant Klebsiella pneumoniae bloodstream infection: a prospective cohort study

Liver transplantation is associated with good clinical outcome in patients with active tuberculosis and acute liver failure due to anti‐tubercular treatment

Radiologic findings of Fusarium pneumonia in neutropenic patients

Risk factors for infections in myelofibrosis: role of disease status and treatment. A multicenter study of 507 patients

Fungal Drug Resistance and Pharmacologic Considerations of Dosing Newer Antifungal Therapies

Polyene Antifungal Agents

Improved Radiographic Imaging of Invasive Fungal Disease: The Cornerstone to Antifungal Stewardship in the Hematology Units?

Computerized tomographic pulmonary angiography discriminates invasive mould disease of the lung from lymphoma

Epidemiology and outcomes of bloodstream infection in patients with cirrhosis

Carbapenem‐resistant Klebsiella pneumoniae colonization at liver transplantation: A management challenge

Risk factors for early mortality in haematological malignancy patients with pulmonary mucormycosis

Epidemiology and sites of involvement of invasive fungal infections in patients with haematological malignancies: a 20‐year autopsy study

Routine use of a real-time polymerase chain reaction method for detection of bloodstream infections in neutropaenic patients

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