Search results for: David Vearrier

Items from 1 to 13 out of 13 results

article

Clinical Pharmacology, Toxicity, and Abuse Potential of Opioids

David Vearrier, Oliver Grundmann

The Journal of Clinical Pharmacology > 61 > S2 > S70 - S88

Opioids were the most common drug class resulting in overdose deaths in the United States in 2019. Widespread clinical use of prescription opioids for moderate to severe pain contributed to the ongoing opioid epidemic with the subsequent emergence of fentanyl‐laced heroin. More potent analogues of fentanyl and structurally diverse opioid receptor agonists such as AH‐7921 and MT‐45 are fueling an increasingly...

article

Neonatal Sepsis

Muhammed Ershad, Ahmed Mostafa, Maricel Dela Cruz, David Vearrier

Current Emergency and Hospital Medicine Reports > 2019 > 7 > 3 > 83-90

Purpose of Review Neonatal sepsis is a diagnosis made in infants less than 28 days of life and consists of a clinical syndrome that may include systemic signs of infection, circulatory shock, and multisystem organ failure. Recent Findings Commonly involved bacteria include Staphylococcus aureus and Escherichia coli. Risk factors include central venous catheter use and prolonged hospitalization....

article

Gadolinium Aspiration Following Inadvertent Endotracheal Tube Cuff Injection in a Pediatric Patient

Ahmed Mamdouh Taha Mostafa, Muhammed Ershad, Maricel Dela Cruz, Rita G McKeever, more

Journal of Medical Toxicology > 2019 > 15 > 3 > 202-204

Introduction Gadolinium-based contrast agents (GBCA) are frequently used for MRI contrast studies. We report a case of pulmonary aspiration secondary to inadvertent GBCA injection. Case Report A 12-year-old female with a past medical history significant for mitochondrial disorder, bronchial asthma, autism, recurrent urinary tract infection, epilepsy, developmental delay, dysautonomia, and thrombocytopenia...

article

The American Academy of Clinical Toxicology Question of the Day

Ryan Surmaitis, Masood Khalid, Rita McKeever, David Vearrier, more

Disease-a-Month > 2017 > 63 > 8 > 182-234

article

Evaluation of a Food and Drug Administration Mandate to Limit Acetaminophen in Prescription Combination Products

David Goldberger, David Vearrier

Journal of Medical Toxicology > 2017 > 13 > 4 > 303-308

Introduction In 2014, the US Food and Drug Administration limited the production of prescription acetaminophen-opioid combination products to 325 mg per dose unit. The goal of this mandate was to decrease the likelihood of unintentional acetaminophen hepatotoxicity. This study was designed to determine if this federal regulation has succeeded in reducing unintentional acetaminophen-induced hepatotoxicity...

article

Issues in driving impairment

David Vearrier, Laura Vearrier, Rita McKeever, Jolene Okaneku, more

Disease-a-Month > 2016 > 62 > 4 > 72-116

chapter

Biological testing for drugs of abuse

David Vearrier, John A. Curtis, Michael I. Greenberg

Experientia Supplementum > Molecular, Clinical and Environmental Toxicology > 489-517

Testing for drugs of abuse has become commonplace and is used for a variety of indications. Commonly employed testing methods include immunoassay and chromatography. Testing methods vary in their sensitivity, specificity, time, and cost. While urine remains the most common body fluid used for testing of drugs of abuse, over the last several decades the use of alternative matrices such as blood, sweat,...

article

K2—Not the Spice of Life; Synthetic Cannabinoids and ST Elevation Myocardial Infarction: A Case Report

Rita G. McKeever, David Vearrier, Dorian Jacobs, Gregory LaSala, more

Journal of Medical Toxicology > 2015 > 11 > 1 > 129-131

Introduction The adverse effects of synthetic cannabinoids are not well-described nor have they been thoroughly studied. Case Report A 16-year-old male with a past medical history of asthma and attention deficit hyperactivity disorder (ADHD) presented to the emergency department (ED) complaining of 24 h of substernal pressure associated with dyspnea, nausea, and vomiting. He reported smoking...

article

Phenol Toxicity Following Cutaneous Exposure to Creolin®: A Case Report

David Vearrier, Dorian Jacobs, Michael I. Greenberg

Journal of Medical Toxicology > 2015 > 11 > 2 > 227-231

Introduction Phenol is a caustic that may cause cutaneous or gastrointestinal burns depending on the route of exposure. Significant absorption may result in systemic toxicity. We present a case of topical phenol exposure resulting in cutaneous burns and systemic phenol toxicity. Case report A 9-year-old girl was exposed to Creolin®, a general-purpose disinfectant containing phenol, when her mother...

article

Methamphetamine: History, Pathophysiology, Adverse Health Effects, Current Trends, and Hazards Associated with the Clandestine Manufacture of Methamphetamine

David Vearrier, Michael I. Greenberg, Susan Ney Miller, Jolene T. Okaneku, more

Disease-a-Month > 2012 > 58 > 2 > 38-89

article

Addressing Obstructive Sleep Apnea in the Emergency Department

David Vearrier, Barbara Phillips, Michael I. Greenberg

Journal of Emergency Medicine > 2011 > 41 > 6 > 728-740

Background: Obstructive sleep apnea (OSA) is a prevalent, serious disease that is under-recognized and under-treated. It results from a combination of increased pharyngeal collapsibility and impaired compensatory pharyngeal muscle dilator activity. OSA causes serious morbidity and mortality. OSA is also a public health problem in that it is an independent cause of car crashes, at great cost to society...