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PURPOSE: To determine whether outcome after conservative surgery and radiation therapy for young women is affected by having a family history (FH) suggestive of an inherited susceptibility to breast cancer.MATERIALS AND METHODS: Between 1968 and 1986, 205 patients 36 years of age or younger at diagnosis were treated with breast-conserving surgery and radiation therapy for clinical stage I or II invasive...
Purpose: Lobular carcinoma in situ, when found in an otherwise benign breast biopsy, is associated with an increased risk of developing a subsequent invasive breast cancer. Among patients with an infiltrating cancer resected without margin assessment, the extent of ductal carcinoma in situ is an established risk factor for LR after CS and RT. However, the association between the presence and extent...
We performed a one-arm prospective trial, 1986–92, to test the hypothesis that RT can be safely omitted after CS in selected pts with early-stage breast cancer. Pts were selected to include unicentric, clinical T1 carcinomas with neither an extensive intraductal component nor lymphatic vessel invasion. We required histologically negative margins of≥1cm and pathologically negative axillary nodes. The...
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