Gian Luca Scoarughi

article

Low‐intensity pulsed ultrasound affects growth, differentiation, migration, and epithelial‐to‐mesenchymal transition of colorectal cancer cells

Donatella Lucchetti, Luigi Perelli, Filomena Colella, Claudio Ricciardi‐Tenore, more

Journal of Cellular Physiology > 235 > 6 > 5363 - 5377

Ultrasound (US) offers potentially important opportunities from a therapeutic point of view. Thus, the study of the biological effects of US on cancer cells is important to understand the consequences of these changes on the malignant phenotype. This study aimed to investigate the effects of low‐intensity ultrasound (LIPUS) on the phenotype of colorectal cancer cell lines. Cell proliferation was evaluated...

article

5th International Symposium on Focused Ultrasound

Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, more

Journal of Therapeutic Ultrasound > 2016 > 4 > 1 > 1-113

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Use of Immunodiagnostics for the Early Detection of Biofilm Infections

Laura Selan, Jennifer Kofonow, Gian Luca Scoarughi, Tim Vail, more

Springer Series on Biofilms > The Role of Biofilms in Device-Related Infections > 219-237

Biofilm infections are a therapeutic and diagnostic challenge due to their location and persistence. Specimen culturing is the golden standard for diagnosing bacterial infections, but recent investigation of the ability of this technique to grow bacteria from a biofilm has indicated that it is not reliable. Other testing modalities, such as PCR and serology assays, are either nonspecific for biofilm...

article

Phosphorylcholine Impairs Susceptibility to Biofilm Formation of Hydrogel Contact Lenses

Laura Selan, Stefano Palma, Gian Luca Scoarughi, Rosanna Papa, more

American Journal of Ophthalmology > 2009 > 147 > 1 > 134-139

To compare silicone-hydrogel, poly(2-hydroxyethyl methacrylate) (pHEMA), and phosphorylcholine-coated (PC-C) contact lenses in terms of their susceptibility to biofilm formation by Staphylococcus epidermidis and Pseudomonas aeruginosa.Laboratory investigation.Biofilm formation on colonized test lenses was evaluated with confocal microscopy and in vitro antibiotic susceptibility assays. The results...

article

Interspecific transfer of mammalian artificial chromosomes between farm animals

Filomena Monica Cavaliere, Gian Luca Scoarughi, Carmen Cimmino

Chromosome Research > 2009 > 17 > 4 > 507-517

It is often desirable to transfer a mammalian artificial chromosome (MAC) from the cells of one species to those of another. Attempts to carry out such transfer have been successful in some cases and have failed in others. In this study we have tested the hypothesis that centromeric DNA sequence similarity could be a useful criterion for determining MAC host range. Homology studies indicated that...

article

Protease treatment affects both invasion ability and biofilm formation in Listeria monocytogenes

Catia Longhi, Gian Luca Scoarughi, Federica Poggiali, Andrea Cellini, more

Microbial Pathogenesis > 2008 > 45 > 1 > 45-52

Listeria monocytogenes is a notably invasive bacterium associated with life-threatening food-borne disease in humans. Several surface proteins have been shown to be essential in the adhesion of L. monocytogenes, and in the subsequent invasion of phagocytes. Because the control of the invasion of host cells by Listeria could potentially hinder its spread in the infected host, we have examined the effects...

article

Stringent control in the archaeal genus Sulfolobus

Andrea Cellini, Gian Luca Scoarughi, Paola Poggiali, Iolanda Santino, more

Research in Microbiology > 2004 > 155 > 2 > 98-104

Six Archaea belonging to the phylum Euryarchaeota were previously analyzed with respect to stringent control. Only one of the strains studied was shown to possess Bacteria-like stringent control over stable RNA accumulation; ppGpp and pppGpp production was totally lacking in all Archaea analyzed. To broaden our knowledge of stringent control in the Archaea, we examined here the accumulation of stable...

article

Molecular characterization of Burkholderia cepacia isolates from cystic fibrosis (CF) patients in an Italian CF center

Andrea Petrucca, Paola Cipriani, Piera Valenti, Daniela Santapaola, more

Research in Microbiology > 2003 > 154 > 7 > 491-498

Bacteria of the Burkholderia cepacia complex consist of a number of closely related genomic species (genomovars) potentially pathogenic for cystic fibrosis (CF) patients, collectively referred to as the B. cepacia complex. The genomovar status and epidemiological relatedness of B. cepacia complex strains recovered from CF patients, attending a CF Center at the University Hospital ''Policlinico Umberto...

article

Effect of amino acid starvation on glucose transport in two archaeal organisms

Gian Luca Scoarughi, Iolanda Santino, Rosa Sessa, Carmen Cimmino, more

FEMS Microbiology Letters > 2003 > 218 > 1 > 47-50

When protein synthesis is arrested by amino acid starvation, Escherichia coli wild-type strains show stringent control (SC) over stable RNA (sRNA) accumulation as well as a large number of other growth-related processes. One of the events under SC is transport of metabolites. Thus, under amino acid starvation, E. coli fails to accumulate the non-metabolizable glucose analog α-methyl-D-glucoside, whereas...

article

Construction of a swine artificial chromosome: a novel vector for transgenesis in the pig

Paola Poggiali, Gian Luca Scoarughi, Marialuisa Lavitrano, Pierluigi Donini, more

Biochimie > 2002 > 84 > 11 > 1143-1150

A de novo SAC was constructed by making use of YAC technology and a humanized yeast strain. The construct (about 310 kb) contained pig centromeric DNA and the Neo gene. The construct was introduced into a pig cell line by yeast-mammalian cell fusion and G418 resistant clones were obtained. One clone was characterized by FISH and shown to contain an episomally located microchromosome containing YAC,...

INFONA - science communication portal

Search results for: Gian Luca Scoarughi

Low‐intensity pulsed ultrasound affects growth, differentiation, migration, and epithelial‐to‐mesenchymal transition of colorectal cancer cells

5th International Symposium on Focused Ultrasound

Use of Immunodiagnostics for the Early Detection of Biofilm Infections

Phosphorylcholine Impairs Susceptibility to Biofilm Formation of Hydrogel Contact Lenses

Interspecific transfer of mammalian artificial chromosomes between farm animals

Protease treatment affects both invasion ability and biofilm formation in Listeria monocytogenes

Stringent control in the archaeal genus Sulfolobus

Molecular characterization of Burkholderia cepacia isolates from cystic fibrosis (CF) patients in an Italian CF center

Effect of amino acid starvation on glucose transport in two archaeal organisms

Construction of a swine artificial chromosome: a novel vector for transgenesis in the pig

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