Search results for: Shinsuke Hisaka

Items from 1 to 11 out of 11 results

article

Effect of Schisandrae Fructus on glycyrrhizin content in Kampo extracts containing Glycyrrhizae Radix used clinically in Japan

Mitsuhiko Nose, Momoka Tada, Asuka Kato, Shinsuke Hisaka, more

Journal of Natural Medicines > 2019 > 73 > 4 > 834-840

Glycyrrhizae Radix is an important crude drug in Japan and is the most frequently prescribed drug in Kampo medicines for the treatment of a wide range of diseases. Glycyrrhizin (GL), the major active ingredient of Glycyrrhizae Radix, has various pharmacological actions but causes adverse effects such as pseudoaldosteronism. In a previous study, the GL content of shoseiryuto was found to be unexpectedly...

article

Evaluation of the safety and efficacy of Glycyrrhiza uralensis root extracts produced using artificial hydroponic-field hybrid cultivation systems II: comparison of serum concentration of glycyrrhetinic acid serum concentration in mice

Mitsuhiko Nose, Kazuma Yamanaka, Shinsuke Hisaka, Takayuki Inui, more

Journal of Natural Medicines > 2019 > 73 > 3 > 661-666

To evaluate the safety and efficacy of Glycyrrhiza uralensis root produced using artificial hydroponic and artificial hydroponic-field hybrid cultivation systems, we investigated the pharmacokinetics of a major metabolite of glycyrrhizin (GL), glycyrrhetinic acid (GA). Hot water extracts obtained from the roots of the artificial hydroponic-field hybrid cultivated Glycyrrhiza uralensis were orally...

article

Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system

Hiroshi Akiyama, Mitsuhiko Nose, Hajime Takiguchi, Keiichi Sugiyama, more

Journal of Natural Medicines > 2019 > 73 > 3 > 608-613

As a part of the investigation of the safety and efficacy of the cultivated Coptis japonica rhizome extracts using an artificial hydroponic cultivation system, the mutagenetic and anti-allergic activities were evaluated. Some extracts of commercial crude drugs of Coptis sp. were also evaluated for the comparison. None of the extracts showed a significant mutagenicity in Salmonella typhimurium TA102...

article

Correction to: Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan

Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, more

Journal of Natural Medicines > 2018 > 72 > 2 > 593-593

The article Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan, written by Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, Shinsuke Hisaka, Sayaka Masada, Masato Homma and Takashi Hakamatsuka, was originally published Online First without open access. After publication in volume 71, issue 4, page 711–722 the author...

article

Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan

Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, more

Journal of Natural Medicines > 2017 > 71 > 4 > 711-722

Glycyrrhizae Radix is the most frequently used crude drug in Japan and is prescribed in Kampo medicine for the treatment of a wide range of diseases. The major active ingredient of Glycyrrhizae Radix, glycyrrhizin (GL), has been shown to possess various pharmacological actions, but is also known to cause adverse effects such as pseudoaldosteronism. To avoid the adverse effects of GL, precautions have...

article

Propanoylation Derived from Lipid Peroxides Modulates the Properties of Amyloid Protein

Shinsuke Hisaka, Chiyuri Yoshimura, Shoichi Tashima, Saki Tsurumi, more

Free Radical Biology and Medicine > 2015 > 87 > S1 > S129-S130

article

Suppressive effect of the hot-water extract of Ficus pseudopalma Blanco leaves on the postprandial increase in blood glucose level in mice

Reginald B. Salonga, Shinsuke Hisaka, Jasmin S. Mendoza, Yoshiaki Takaya, more

Journal of Natural Medicines > 2013 > 67 > 4 > 725-729

The use of medicinal plants with anti-diabetic properties continues because of the high cost of diabetes mellitus treatment. In the Bicol region of the Philippines, one local source is the leaves of Ficus pseudopalma Blanco (Philippine fig), which is utilized as an ingredient of their cuisine, and the decoction of its leaves is believed to have a blood-glucose lowering effect. The aim of this study...

article

The immunological and chemical detection of N-(hexanoyl)phosphatidylethanolamine and N-(hexanoyl)phosphatidylserine in an oxidative model induced by carbon tetrachloride

Shinsuke Hisaka, Naomi Yamada, Kentaro Naito, Toshihiko Osawa

Biochemical and Biophysical Research Communications > 2010 > 393 > 4 > 631-636

Lipid peroxidation products have a high reactivity against the primary amino groups of biomolecules such as aminophospholipids, proteins, and DNA. Until now, many papers have reported about the modification of biomolecules derived from lipid peroxides. Our group has also reported that aminophospholipids, such as phosphatidylethanolamine (PE), can be modified by lipid peroxidation including 13-hydroperoxyoctadecadienoic...

article

Propanoylation of Amyloid β is Trigger to the Aggregation and Enhanced its Neurotoxicity

Shinsuke Hisaka, Yoshimi Hayashi, Masayo Shamoto-Nagai, Yoji Kato, more

Free Radical Biology and Medicine > 2010 > 49 > Supplement > S80

article

Chemical and immunochemical identification of propanoyllysine derived from oxidized n-3 polyunsaturated fatty acid

Shinsuke Hisaka, Yoji Kato, Noritoshi Kitamoto, Akihiro Yoshida, more

Free Radical Biology and Medicine > 2009 > 46 > 11 > 1463-1471

It is known that n-3 polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid and eicosapentaenoic acid, are rapidly oxidized in vitro. Nɛ-(propanoyl)lysine (propionyllysine, or PRL) is formed from the reaction of the oxidized products of n-3 PUFAs and lysine. To evaluate the oxidized n-3 PUFA-derived protein modifications in vivo, we have developed detection methods using a novel monoclonal...

article

Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism

Xuebo Liu, Takahiro Shibata, Shinsuke Hisaka, Toshihiko Osawa

Brain Research > 2009 > 1254 > Complete > 18-27

Astaxanthin is a powerful antioxidant that occurs naturally in a wide variety of living organisms. The aim of this study is to investigate the effect and the mechanism of astaxanthin on reactive oxygen species (ROS)-mediated apoptosis in dopaminergic SH-SY5Y cells. The treatment with DHA hydroperoxide (DHA-OOH) or 6-hydroxydopamine (6-OHDA), either of which is ROS-inducing neurotoxin, led to a significant...

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Keywords

GLYCYRRHIZAE RADIX (2)
KAMPO EXTRACTS (2)
LIPID PEROXIDATION (2)
PH (2)
PSEUDOALDOSTERONISM (2)
FICUS PSEUDOPLAMA BLANCO (1)
AMIDE-TYPE ADDUCT (1)
AMINOPHOSPHOLIPID (1)
ARTIFICIAL HYDROPONIC-FIELD HYBRID CULTIVATION (1)
ASTAXANTHIN (1)
BERBERINE (1)
BIOMARKER (1)
COPTIS JAPONICA (1)
DIABETES MELLITUS (1)
FREE RADICALS (1)
GLYCYRRHETINIC ACID (GA) (1)
GLYCYRRHIZA URALENSIS (1)
GLYCYRRHIZIN (1)
GLYCYRRHIZIN (GL) (1)
HEXANOYLLYSINE (1)
HPLC (1)
HYDROPONIC CULTIVATION (1)
MITOCHONDRIA PROTECTION (1)
MONOCLONAL ANTIBODY (1)
MORACEAE (1)
NEURONAL APOPTOSIS (1)
ORAL ADMINISTRATION (1)
ORAL GLUCOSE TOLERANCE TEST (OGTT) (1)
OXIDATIVE MODIFICATION (1)
PARKINSON'S DISEASE (1)
POSTPRANDIAL BLOOD GLUCOSE LEVEL (1)
PROPANOYLLYSINE (1)
PUFA (1)
REACTIVE OXYGEN SPECIE (1)
SCHISANDRAE FRUCTUS (1)
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Springer (6)
Elsevier (5)

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Search results for: Shinsuke Hisaka

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