Search results for: Zainulabedin M. Saiyed

Items from 1 to 11 out of 11 results

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Safety and toxicological evaluation of Meratrim®: An herbal formulation for weight management

Zainulabedin M. Saiyed, Krishanu Sengupta, Alluri V. Krishnaraju, Golakoti Trimurtulu, more

Food and Chemical Toxicology > 2015 > 78 > Complete > 122-129

Meratrim is a unique dietary ingredient consisting of extracts from Sphaeranthus indicus flower heads and Garcinia mangostana fruit rind. Clinical studies have demonstrated that Meratrim is effective and well-tolerated in weight management. Herein we assessed the broad spectrum safety of Meratrim in a battery of in vitro and animal toxicological studies including a sub-chronic repeated-dose 13-week...

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Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study

James P. Lugo, Zainulabedin M. Saiyed, Nancy E. Lane

Nutrition Journal > 2015 > 15 > 1 > 1-15

Background Undenatured type II collagen (UC-II) is a nutritional supplement derived from chicken sternum cartilage. The purpose of this study was to evaluate the efficacy and tolerability of UC-II for knee osteoarthritis (OA) pain and associated symptoms compared to placebo and to glucosamine hydrochloride plus chondroitin sulfate (GC). Methods One hundred ninety one volunteers were randomized into...

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Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers

James P Lugo, Zainulabedin M Saiyed, Francis C Lau, Jhanna Pamela L Molina, more

Journal of the International Society of Sports Nutrition > 2013 > 10 > 1 > 1-12

Background UC-II contains a patented form of undenatured type II collagen derived from chicken sternum. Previous preclinical and clinical studies support the safety and efficacy of UC-II in modulating joint discomfort in osteoarthritis and rheumatoid arthritis. The purpose of this study was to assess the efficacy and tolerability of UC-II in moderating joint function and joint pain due to strenuous...

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Effect of methamphetamine on expression of HIV coreceptors and CC-chemokines by dendritic cells

Madhavan P.N. Nair, Zainulabedin M. Saiyed

Life Sciences > 2011 > 88 > 21-22 > 987-994

The United States is currently experiencing an entangled epidemic of HIV infection and use of different drugs of abuse, especially of methamphetamine (Meth). Blood monocyte-derived dendritic cells (DC) are the first line of defense against HIV-1 infection, and are the initial target of HIV-1 infection in injection drug users. DC-SIGN present on dendritic cells is the first molecule that facilitates...

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HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: Implication for HIV-associated neurocognitive disorder (HAND)

Zainulabedin M. Saiyed, Nimisha Gandhi, Marisela Agudelo, Jessica Napuri, more

Neurochemistry International > 2011 > 58 > 6 > 656-664

Histone deacetylases (HDACs) play a pivotal role in epigenetic regulation of transcription and homeostasis of protein acetylation in histones and other proteins involved in chromatin remodeling. Histone hypoacetylation and transcriptional dysfunction have been shown to be associated with a variety of neurodegenerative diseases. More recently, neuron specific overexpression of HDAC2 has been shown...

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Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS

Thangavel Samikkannu, Marisela Agudelo, Nimisha Gandhi, Pichili V. B. Reddy, more

Journal of NeuroVirology > 2011 > 17 > 3 > 230-238

HIV-1 clades (subtypes) differentially contribute to the neuropathogenesis of HIV-associated dementia (HAD) in neuroAIDS. HIV-1 envelop protein, gp120, plays a major role in neuronal function. It is not well understood how these HIV-1 clades exert these neuropathogenic differences. The N-methyl-d-aspartate (NMDA) receptor-reduced glutamine synthesis could lead to secretion of neurotoxins such as arachidonic...

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MicroRNA: implications in HIV, a brief overview

Sudheesh Pilakka-Kanthikeel, Zainulabedin M. Saiyed, Jessica Napuri, Madhavan P. N. Nair

Journal of NeuroVirology > 2011 > 17 > 5 > 416-423

MicroRNAs (miRNAs) are 20–22 nucleotide length noncoding RNA molecules that represent key regulators of many normal cellular functions. miRNAs undergo two processing steps which transform a long primary transcript into the mature miRNA. Available literatures demonstrate the association between alterations in the expression of miRNAs and the progression of numerous human disorders. Even though significant...

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Implications of ER Stress, the Unfolded Protein Response, and Pro‐ and Anti‐Apoptotic Protein Fingerprints in Human Monocyte‐Derived Dendritic Cells Treated With Alcohol

Nawal M. Boukli, Zainulabedin M. Saiyed, Martha Ricaurte, José W. Rodriguez, more

Alcoholism: Clinical and Experimental Research > 34 > 12 > 2081 - 2088

Background: Dendritic cells (DCs) are responsible for the activation of T cells and B cells. There is accumulating evidence that psychoactive substances such as alcohol can affect immune responses. We hypothesize that this occurs by modulating changes in proteins triggering a process known as unfolded protein response (UPR). This process protects cells from the toxic effects of misfolded proteins...

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Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: Implications for HIV-1-associated neurocognitive disorder

Nimisha Gandhi, Zainulabedin M. Saiyed, Jessica Napuri, Thangavel Samikkannu, more

Journal of NeuroVirology > 2010 > 16 > 4 > 294-305

In recent years, increasing interest has emerged to assess the human immunodeficiency virus type 1 (HIV-1) clade C viral pathogenesis due to its anticipated spread in the United States and other western countries. Previous studies suggest that clade C is less neuropathogenic than clade B; however, the underlying mechanism is poorly understood. Additionally, the interactive role of drugs of abuse such...

article

Methamphetamine Enhances HIV-1 Infectivity in Monocyte Derived Dendritic Cells

Madhavan P. N. Nair, Zainulabedin M. Saiyed, Narayanan Nair, Nimisha H. Gandhi, more

Journal of Neuroimmune Pharmacology > 2009 > 4 > 1 > 129-139

The US is currently experiencing an epidemic of methamphetamine (Meth) use as a recreational drug. Recent studies also show a high prevalence of HIV-1 infection among Meth users. We report that Meth enhances HIV-1 infectivity of dendritic cells as measured by multinuclear activation of a galactosidase indicator (MAGI) cell assay, p24 assay, and LTR-RU5 amplification. Meth induces increased HIV-1 infection...

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AZT 5′-triphosphate nanoformulation suppresses human immunodeficiency virus type 1 replication in peripheral blood mononuclear cells

Zainulabedin M. Saiyed, Nimisha H. Gandhi, Madhavan P. N. Nair

Journal of NeuroVirology > 2009 > 15 > 4 > 343-347

Inefficient cellular phosphorylation of nucleoside and nucleotide analog reverse transcriptase inhibitors (NRTIs) to their active nucleoside 5′-triphosphate (NTPs) form is one of the limitations for human immunodeficiency virus (HIV) therapy. We report herein direct binding of 3′-azido-3′-deoxythymidine-5′-triphosphate (AZTTP) onto magnetic nanoparticles (Fe₃O₄; magnetite) due to ionic interaction...

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