Search results for: Kelly Chen

Items from 1 to 18 out of 18 results

article

Individual differences in threat and reward neural circuitry activation: Testing dimensional models of early adversity, anxiety and depression

Katherine S. Young, Camilla Ward, Meghan Vinograd, Kelly Chen, more

European Journal of Neuroscience > 55 > 9-10 > 2739 - 2753

Altered functioning of the brain's threat and reward circuitry has been linked to early life adversity and to symptoms of anxiety and depression. To date, however, these relationships have been studied largely in isolation and in categorical‐based approaches. It is unclear to what extent early life adversity and psychopathology have unique effects on brain functioning during threat and reward processing...

article

Unequal opportunities and public policy: The impact of parental disability benefits on child postsecondary attendance

Kelly Chen, Lars Osberg, Shelley Phipps

Canadian Journal of Economics/Revue canadienne d'économique > 52 > 4 > 1401 - 1432

This paper uses Canada's National Longitudinal Survey of Children and Youth to examine whether greater cash transfers available to parents with disabilities when their child was aged 5 to 15 increase the chances that the child will attend postsecondary education (PSE) as a young adult. We exploit differences across provinces and over time in the generosity of provincial disability benefits programs...

article

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

Nikolaos Tsamandouras, Wen Li Kelly Chen, Collin D. Edington, Cynthia L. Stokes, more

The AAPS Journal > 2017 > 19 > 5 > 1499-1512

Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose. However, the need for more physiologically realistic in vitro models has recently fueled the emerging field of tissue-engineered 3D cultures, also referred to as organs-on-chips, or microphysiological...

article

Social calls honestly signal female competitive ability in Asian particoloured bats

Bo Luo, Guanjun Lu, Kelly Chen, Dongge Guo, more

Animal Behaviour > 2017 > 127 > C > 101-108

Why a variety of social animals vocalize during agonistic foraging interactions remains obscure. One possibility is that these signals advertise the signaller's competitive ability, playing a role in the defence of food resources, yet there is limited evidence in support of this idea. Here, we used adult female Asian particoloured bats, Vespertilio sinensis, to test whether individual variation in...

chapter

Supplier management in photomask field

Kelly Chen, Eric Guo, Sammy Chen, Sherry Zhu

2016 IEEE International Conference on Industrial Engineering and Engineering Management (IEEM) > 1928 - 1932

2016 IEEE International Conference on Industrial Engineering and Engineering Management (IEEM)

Many industries such as photomask field are putting more and more emphasis on enhancing their core market competitiveness for the moment and they may achieve this goal through efficient supplier management because nowadays suppliers have become indispensable partners of enterprises for long-term development and interest. Thereby, enterprises ought to pay more attention to supplier management and improve...

article

Young in class: Implications for inattentive/hyperactive behaviour of Canadian boys and girls

Kelly Chen, Nicole Fortin, Shelley Phipps

Canadian Journal of Economics/Revue canadienne d'économique > 48 > 5 > 1601 - 1634

Using data from the Statistics Canada National Longitudinal Survey of Children and Youth (NLSCY), this paper investigates the impact of school entry age on inattentive/hyperactive behaviours. We employ both an across‐provinces and time difference‐in‐differences approach and a within‐province regression discontinuity design. We find that being young in class causes greater inattentive/hyperactive behaviour,...

article

Heart valve regeneration: the need for systems approaches

Jenna Usprech, Wen Li Kelly Chen, Craig A. Simmons

Wiley Interdisciplinary Reviews: Systems Biology and Medicine > 8 > 2 > 169 - 182

Tissue‐engineered heart valves are promising alternatives to address the limitations of current valve replacements, particularly for growing children. Current heart valve tissue engineering strategies involve the selection of biomaterial scaffolds, cell types, and often in vitro culture conditions aimed at regenerating a valve for implantation and subsequent maturation in vivo. However, identifying...

article

Luminescent Thermochromism in a Gold(I)–Copper(I) Phosphine–Pyridine Complex

Kelly Chen, Vincent J. Catalano

European Journal of Inorganic Chemistry > 2015 > 31 > 5254 - 5261

The Au^I complex [Au(Ph₂PCH₂py)₂]BF₄ (1) was prepared by mixing (tetrahydrothiophene)gold(I) chloride with 2‐[(diphenylphosphino)methyl]pyridine (Ph₂PCH₂py) in dichloromethane. The addition of [Cu(NCCH₃)₄]BF₄ to 1 produced green‐luminescent [AuCu(Ph₂PCH₂py)₂(NCCH₃)₂](BF₄)₂ (2). When crystals of 2 were exposed to air, two acetonitrile molecules were lost to form crystals of yellow‐luminescent [AuCu(Ph...

article

Inter-generational effects of disability benefits: evidence from Canadian social assistance programs

Kelly Chen, Lars Osberg, Shelley Phipps

Journal of Population Economics > 2015 > 28 > 4 > 873-910

Individuals with disabilities face greater challenges in the labor market than able-bodied individuals, and a growing body of research is finding that their children also tend to have more developmental problems than the children of able-bodied parents. Can transfer payments help reduce this gap? In this paper, we present the first evidence on how parental disability benefits affect the well-being...

article

Child health and parental paid work

Peter Burton, Kelly Chen, Lynn Lethbridge, Shelley Phipps

Review of Economics of the Household > 2017 > 15 > 2 > 597-620

We ask how the paid work of Canadian married mothers and fathers is affected when a child has a physical/mental condition or health problem that leads to restrictions in daily activities. Using the Statistics Canada National Longitudinal Survey of Children and Youth, we find that married mothers of children with disabilities are less likely to engage in paid work and/or work fewer paid hours per week...

article

Hydrogel Substrate Stiffness and Topography Interact to Induce Contact Guidance in Cardiac Fibroblasts

Shahed Al‐Haque, Jason W. Miklas, Nicole Feric, Loraine L. Y. Chiu, more

Macromolecular Bioscience > 12 > 10 > 1342 - 1353

Previous studies demonstrated the importance of substrate stiffness and topography on the phenotype of many different cell types including fibroblasts. Yet the interaction of these two physical parameters remains insufficiently characterized, in particular for cardiac fibroblasts. Most studies focusing on contact guidance use rigid patterned substrates. It is not known how the ability of cardiac fibroblasts...

article

Macromol. Biosci. 10/2012

Shahed Al‐Haque, Jason W. Miklas, Nicole Feric, Loraine L. Y. Chiu, more

Macromolecular Bioscience > 12 > 10 > n/a - n/a

Cover: The ability of cardiac fibroblasts to sense the topography of their microenvironment varies with substrate stiffness. Stiffness and topography have an interactive effect on cell morphology and alignment. This paper demonstrates that 18 kPa topographically modified substrates optimally induce elongation and alignment of cardiac fibroblasts. Further details can be found in the article by S. Al‐Haque,...

article

Aberrant Frontal Lobe Maturation in Adolescents with Fragile X Syndrome is Related to Delayed Cognitive Maturation

Signe Bray, Melissa Hirt, Booil Jo, Scott S. Hall, more

Biological Psychiatry > 2011 > 70 > 9 > 852-858

Fragile X syndrome (FXS) is the most common known heritable cause of intellectual disability. Prior studies in FXS have observed a plateau in cognitive and adaptive behavioral development in early adolescence, suggesting that brain development in FXS may diverge from typical development during this period.In this study, we examined adolescent brain development using structural magnetic resonance imaging...

article

Comparison of Two Chlorhexidine Gluconate (CHG) Containing Catheter Site Dressings

Sandra Gonzalez, Shubhangi Bhende, Daniel Burkley, Kelly Chen, more

American Journal of Infection Control > 2011 > 39 > 5 > E42

article

Questioning the Existence of “Class Effect” in Catheter Site Dressings for Preventing Catheter Related Blood Stream Infections

Liza G. Ovington, Shubhangi Bhende Bhende, Daniel Burkley, Kelly Chen, more

American Journal of Infection Control > 2011 > 39 > 5 > E40-E41

article

Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine

Wen Li Kelly Chen, Craig A. Simmons

Advanced Drug Delivery Reviews > 2011 > 63 > 4-5 > 269-276

Diseased tissues are noted for their compromised mechanical properties, which contribute to organ failure; regeneration entails restoration of tissue structure and thereby functions. Thus, the physical signature of a tissue is closely associated with its biological function. In this review, we consider a mechanics-centric view of disease and regeneration by drawing parallels between in vivo tissue-level...

article

Integration of statistical modeling and high-content microscopy to systematically investigate cell–substrate interactions

Wen Li Kelly Chen, Morakot Likhitpanichkul, Anthony Ho, Craig A. Simmons

Biomaterials > 2010 > 31 > 9 > 2489-2497

Cell–substrate interactions are multifaceted, involving the integration of various physical and biochemical signals. The interactions among these microenvironmental factors cannot be facilely elucidated and quantified by conventional experimentation, and necessitate multifactorial strategies. Here we describe an approach that integrates statistical design and analysis of experiments with automated...

article

Influence of substrate stiffness on the phenotype of heart cells

Bashir Bhana, Rohin K. Iyer, Wen Li Kelly Chen, Ruogang Zhao, more

Biotechnology and Bioengineering > 105 > 6 > 1148 - 1160

Adult cardiomyocytes (CM) retain little capacity to regenerate, which motivates efforts to engineer heart tissues that can emulate the functional and mechanical properties of native myocardium. Although the effects of matrix stiffness on individual CM have been explored, less attention was devoted to studies at the monolayer and the tissue level. The purpose of this study was to characterize the influence...

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