Search results for: Matthew D. Davidson

Items from 1 to 8 out of 8 results

article

Photoinduced Dithiolane Crosslinking for Multiresponsive Dynamic Hydrogels

Benjamin R. Nelson, Bruce E. Kirkpatrick, Connor E. Miksch, Matthew D. Davidson, more

Advanced Materials > 36 > 43 > n/a - n/a

While many hydrogels are elastic networks crosslinked by covalent bonds, viscoelastic hydrogels with adaptable crosslinks are increasingly being developed to better recapitulate time and position‐dependent processes found in many tissues. In this work, 1,2‐dithiolanes are presented as dynamic covalent photocrosslinkers of hydrogels, resulting in disulfide bonds throughout the hydrogel that respond...

article

Multi‐Material Volumetric Additive Manufacturing of Hydrogels using Gelatin as a Sacrificial Network and 3D Suspension Bath

Morgan B. Riffe, Matthew D. Davidson, Gabriel Seymour, Abhishek P. Dhand, more

Advanced Materials > 36 > 34 > n/a - n/a

Volumetric additive manufacturing (VAM) is an emerging layerless method for the rapid processing of reactive resins into 3D structures, where printing is much faster (seconds) than other lithography and direct ink writing methods (minutes to hours). As a vial of resin rotates in the VAM process, patterned light exposure defines a 3D object and then resin that has not undergone gelation can be washed...

article

Injectable MSC Spheroid and Microgel Granular Composites for Engineering Tissue

Nikolas Di Caprio, Matthew D. Davidson, Andrew C. Daly, Jason A. Burdick

Advanced Materials > 36 > 14 > n/a - n/a

Many cell types require direct cell–cell interactions for differentiation and function; yet, this can be challenging to incorporate into 3‐dimensional (3D) structures for the engineering of tissues. Here, a new approach is introduced that combines aggregates of cells (spheroids) with similarly‐sized hydrogel particles (microgels) to form granular composites that are injectable, undergo interparticle...

article

Simultaneous One‐Pot Interpenetrating Network Formation to Expand 3D Processing Capabilities

Abhishek P. Dhand, Matthew D. Davidson, Jonathan H. Galarraga, Taimoor H. Qazi, more

Advanced Materials > 34 > 28 > n/a - n/a

The incorporation of a secondary network into traditional single‐network hydrogels can enhance mechanical properties, such as toughness and loading to failure. These features are important for many applications, including as biomedical materials; however, the processing of interpenetrating polymer network (IPN) hydrogels is often limited by their multistep fabrication procedures. Here, a one‐pot scheme...

article

Microstructured Hydrogels to Guide Self‐Assembly and Function of Lung Alveolospheres

Claudia Loebel, Aaron I. Weiner, Madeline K. Eiken, Jeremy B. Katzen, more

Advanced Materials > 34 > 28 > n/a - n/a

Epithelial cell organoids have increased opportunities to probe questions on tissue development and disease in vitro and for therapeutic cell transplantation. Despite their potential, current protocols to grow these organoids almost exclusively depend on culture within 3D Matrigel, which limits defined culture conditions, introduces animal components, and results in heterogenous organoids (i.e., shape,...

article

Mechanochemical Adhesion and Plasticity in Multifiber Hydrogel Networks

Matthew D. Davidson, Ehsan Ban, Anna C. M. Schoonen, Mu‐Huan Lee, more

Advanced Materials > 32 > 8 > n/a - n/a

The extracellular matrix (ECM) has force‐responsive (i.e., mechanochemical) properties that enable adaptation to mechanical loading through changes in fibrous network structure and interfiber bonding. Imparting such properties into synthetic fibrous materials will allow reinforcement under mechanical load, the potential for material self‐adhesion, and the general mimicking of ECM. Multifiber hydrogel...

article

Hydrogels: Mechanochemical Adhesion and Plasticity in Multifiber Hydrogel Networks (Adv. Mater. 8/2020)

Matthew D. Davidson, Ehsan Ban, Anna C. M. Schoonen, Mu‐Huan Lee, more

Advanced Materials > 32 > 8 > n/a - n/a

In article number 1905719, Jason A. Burdick and co‐workers describe the development of adhesive fibrous hydrogel networks where force induces chemical bonding between mixed fiber populations containing complementary chemical groups. This mechanochemical behavior can be applied to numerous material systems to introduce unique properties, from textiles to biomedical applications.

article

Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitro

Dustin R. Berger, Brenton R. Ware, Matthew D. Davidson, Samuel R. Allsup, more

Hepatology > 61 > 4 > 1370 - 1381

Induced pluripotent stem cell‐derived human hepatocyte‐like cells (iHeps) could provide a powerful tool for studying the mechanisms underlying human liver development and disease, testing the efficacy and safety of pharmaceuticals across different patients (i.e., personalized medicine), and enabling cell‐based therapies in the clinic. However, current in vitro protocols that rely upon growth factors...

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