Search results for: Naoki Muguruma

Items from 1 to 20 out of 89 results

article

miR‐144‐3p/miR‐451a promotes lymphovascular invasion through repression of PTEN/p19 in rectal neuroendocrine tumors

Noriaki Murayama, Koichi Okamoto, Tadahiko Nakagawa, Jinsei Miyoshi, more

Journal of Gastroenterology and Hepatology > 37 > 5 > 919 - 927

Background and Aim Although rectal neuroendocrine tumor (NET‐G1) have potential metastatic capability, even among small tumors, no predictive biomarker for invasion and metastasis has been reported. We analyzed microRNA (miRNA) expression profiles in rectal NET‐G1 tissues with and without lymphovascular invasion (LVI). Moreover, we then investigated their target genes to clarify the mechanism of...

article

Indocyanine green‐labeled dasatinib as a new fluorescent probe for molecular imaging of gastrointestinal stromal tumors

Shota Fujimoto, Naoki Muguruma, Michiyasu Nakao, Hidenori Ando, more

Journal of Gastroenterology and Hepatology > 36 > 5 > 1253 - 1262

Background and Aim It is difficult to differentiate gastrointestinal stromal tumors (GISTs) from other subepithelial lesions under gastrointestinal endoscopy. Because most GISTs express tyrosine kinase receptor c‐KIT, fluorescence‐labeled c‐KIT‐specific tyrosine kinase inhibitors seem to be useful agents for molecular imaging of GIST. We aimed to develop a near‐infrared fluorescent imaging technology...

article

Comparison of therapeutic outcomes of sorafenib and lenvatinib as primary treatments for hepatocellular carcinoma with a focus on molecular‐targeted agent sequential therapy: A propensity score‐matched analysis

Tetsu Tomonari, Yasushi Sato, Joji Tani, Akira Hirose, more

Hepatology Research > 51 > 4 > 472 - 481

Aim The optimal choice between sorafenib (SOR) or lenvatinib (LEN) as the first‐line treatment for unresectable hepatocellular carcinoma (u‐HCC) remains debatable. Using propensity score matching, this study compares the outcomes of SOR and LEN in the molecular‐targeted agent (MTA) sequential treatment of u‐HCC patients. Methods This retrospective, multicenter, observational study recruited 137...

article

Different phenotypes of gastric fundic gland polyposis and cancer in patients with familial adenomatous polyposis depending on Helicobacter pylori infection

Yasuhiro Mitsui, Ayaka Miyoshi, Koichi Okamoto, Naoki Muguruma, more

Gastric Cancer > 2019 > 22 > 6 > 1294-1300

A 37-year-old male with tarry stool presented to our hospital. Esophagogastroduodenoscopy revealed advanced gastric cancer, fundic gland polyposis (FGPsis), and negativity for Helicobacter pylori (HP) infection. Computed tomography exhibited multiple liver tumors. Total colonoscopy (TCS) demonstrated 139 tubular adenomas. He was diagnosed as having unresectable gastric cancer and received systemic...

article

A dose-escalation study of docetaxel, oxaliplatin, and S-1 (DOS) as a first-line therapy for patients with unresectable metastatic gastric cancer

Yasushi Sato, Tamotsu Sagawa, Hiroyuki Ohnuma, Masahiro Hirakawa, more

Cancer Chemotherapy and Pharmacology > 2019 > 83 > 1 > 161-167

Purpose The aim of this study was to determine the recommended dose (RD) for a docetaxel/oxaliplatin/S-1 (DOS) regimen in patients with unresectable gastric cancer and to preliminarily evaluate its efficacy. Methods Previously untreated patients with histologically proven unresectable metastatic gastric cancer were enrolled (n = 16). Docetaxel and oxaliplatin were administered intravenously on day...

article

Massive hemobilia following plastic stent removal in common bile duct cancer associated with primary sclerosing cholangitis (with video)

Hiroshi Miyamoto, Kumiko Tanaka, Fumika Nakamura, Takahiro Ikeda, more

Clinical Journal of Gastroenterology > 2019 > 12 > 1 > 46-51

Hemobilia is defined as bleeding into the biliary tract. Herein, we report a very rare case of massive hemobilia following plastic stent (PS) removal in common bile duct (CBD) cancer. A 72-year-old man with primary sclerosing cholangitis had undergone repeated insertion of a PS into the CBD. Biliary tract biopsy was performed based on suspicion of combined CBD cancer. Biopsy revealed poorly differentiated...

article

First report of an Asian family with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) revealed with the germline mutation of the APC exon 1B promoter region

Yasuhiro Mitsui, Reiko Yokoyama, Shota Fujimoto, Kaizo Kagemoto, more

Gastric Cancer > 2018 > 21 > 6 > 1058-1063

A 48-year-old Japanese female with left hypochondralgia presented at our hospital. Esophagogastroduodenoscopy (EGD) revealed gastric cancers and carpeting fundic gland polyposis (FGPs) without Helicobacter pylori infection. Computed tomography showed multiple liver metastases. Total colonoscopy revealed a colonic tubular adenoma but not polyposis. She was diagnosed as having advanced gastric cancer...

article

Sa1984 - Near-Infrared Molecular Imaging of Gastrointestinal Stromal Tumors using a Novel Fluorescent Probe Indocyanine Green (ICG)-Labeled Dasatinib

Shota Fujimoto, Naoki Muguruma, Michiyasu Nakao, Yoshihiko Miyamoto, more

Gastroenterology > 2018 > 154 > 6(S1) > S-437

article

Sa1209 - Clinicopathological Analyses of Colorectal Polyps and Cancers in Serrated Polyposis Syndrome

Fumika Nakamura, Koichi Okamoto, Kumiko Tanaka, Yasuteru Fujino, more

Gastroenterology > 2018 > 154 > 6(S1) > S-278

article

1027 - Mir-144-3P/451A as a Novel Biomarker for Predicting Recurrence and Metastasis in Rectal Neuroendocrine Tumors Through Targeting Pten/P19

Jinsei Miyoshi, Noriaki Murayama, Tadahiko Nakagawa, Tetsu Tomonari, more

Gastroenterology > 2018 > 154 > 6(S1) > S-196

article

APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism

Rie Harada, Masako Kimura, Yasushi Sato, Tatsuya Taniguchi, more

BMC Gastroenterology > 2018 > 18 > 1 > 1-8

Background It has been reported that some single-nucleotide polymorphisms (SNPs) in lipid regulators such as apolipoproteins and cell surface molecules for hepatitis C virus (HCV) entry into hepatocytes are associated with HCV infection. However, it is unknown how HCV infection is affected by altered lipid metabolism resulting from the SNPs. We investigated the relationship between these SNPs and...

article

A triplet combination with capecitabine/oxaliplatin/irinotecan (XELOXIRI) plus cetuximab as first-line therapy for patients with metastatic colorectal cancer: a dose escalation study

Yasushi Sato, Masahiro Hirakawa, Hiroyuki Ohnuma, Minoru Takahashi, more

Cancer Chemotherapy and Pharmacology > 2017 > 80 > 6 > 1133-1139

Purpose The addition of cetuximab to triplet chemotherapy can increase treatment efficacy for patients with metastatic colorectal cancer (mCRC). We explored the dose-limiting toxicity and feasibility of a triweekly capecitabine, oxaliplatin, irinotecan, plus cetuximab (XELOXIRI plus cetuximab) regimen in patients with wild-type KRAS mCRC. Methods Patients received oxaliplatin (100 mg/m², day 1),...

article

Sa1717 Detection of Aberrant Crypt Foci Using Image-Enhanced Endoscopy

Kaizo Kagemoto, Koichi Okamoto, Tohshi Takaoka, Yasuyuki Okada, more

Gastrointestinal Endoscopy > 2017 > 85 > 5(S) > AB252

article

Efficacy of hybrid endoscopic submucosal dissection (ESD) as a rescue treatment in difficult colorectal ESD cases

Koichi Okamoto, Naoki Muguruma, Kaizo Kagemoto, Yasuhiro Mitsui, more

Digestive Endoscopy > 29 > S2 > 45 - 52

Background and Aim Endoscopic submucosal dissection (ESD), which provides a higher en bloc resection rate than conventional endoscopic mucosal resection (EMR), is considered to be a useful treatment option for large colorectal tumors. However, colorectal ESD is not widely used because of its technical difficulty, risk of complications and time required. To overcome these drawbacks, a simpler modified...

article

Optical Molecular Imaging of Aberrant Crypt Foci in the Human Colon by Glutathione S-Transferase-Activated Fluorogenic Probe

Naoki Muguruma, Koichi Okamoto, Shota Fujimoto, Tadahiko Nakagawa, more

Gastroenterology > 2017 > 152 > 5(S1) > S44

article

Usefulness of Linked Color Imaging System in Endoscopic Diagnosis of Sessile Serrated Adenoma/Polyp: A Novel Image Enhanced Technique

Daisaku Fujimoto, Kaizo Kagemoto, Yasuyuki Okada, Hironori Tanaka, more

Gastroenterology > 2017 > 152 > 5(S1) > S81-S82

article

A New Theranostic Combination of Fluorescent Molecular Imaging and Laser Therapy Targeting C-Kit in Gastrointestinal Stromal Tumors

Shota Fujimoto, Naoki Muguruma, Koichi Okamoto, Misaki Miwa, more

Gastroenterology > 2017 > 152 > 5(S1) > S44

article

Duodenal cancer in a young patient with Peuts-Jeghers syndrome harboring an entire deletion of the STK11 gene

Satoshi Teramae, Koichi Okamoto, Kumiko Tanaka, Reika Matsumoto, more

Clinical Journal of Gastroenterology > 2017 > 10 > 3 > 232-239

A 21-year-old woman with Peuts-Jeghers syndrome (PJS) was referred to our hospital for gastrointestinal surveillance. She had been diagnosed as having PJS from a young age based on her family history and the presence of mucocutaneous pigmentation on her lips and oral mucosa. Her mother and brother had PJS harboring an entire deletion of the STK11 gene. She had tetralogy of Fallot, atrial tachycardia,...

article

Clinicopathological characteristics of serrated polyps as precursors to colorectal cancer: Current status and management

Koichi Okamoto, Shinji Kitamura, Tetsuo Kimura, Tadahiko Nakagawa, more

Journal of Gastroenterology and Hepatology > 32 > 2 > 358 - 367

Serrated polyps have long been thought to lack malignant potential in the human colorectum. However, identification of the serrated pathway to colorectal cancer based on molecular biology has improved our understanding of the pathogenesis of colorectal cancers. Accordingly, serrated polyps such as traditional serrated adenoma and sessile serrated adenoma/polyps (SSA/P) are now considered to be precursor...

article

Colon capsule endoscopy: toward the future

Naoki Muguruma, Kumiko Tanaka, Satoshi Teramae, Tetsuji Takayama

Clinical Journal of Gastroenterology > 2017 > 10 > 1 > 1-6

Colon capsule endoscopy is a wireless and minimally invasive technique for visualization of the whole colon. With recent improvements of technical features in second-generation systems, a more important role for colon capsule endoscopy is rapidly emerging. Although several limitations and drawbacks are yet to be resolved, its usefulness as a tool for colorectal cancer screening and monitoring disease...

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INFONA - science communication portal

Search results for: Naoki Muguruma

miR‐144‐3p/miR‐451a promotes lymphovascular invasion through repression of PTEN/p19 in rectal neuroendocrine tumors

Indocyanine green‐labeled dasatinib as a new fluorescent probe for molecular imaging of gastrointestinal stromal tumors

Comparison of therapeutic outcomes of sorafenib and lenvatinib as primary treatments for hepatocellular carcinoma with a focus on molecular‐targeted agent sequential therapy: A propensity score‐matched analysis

Different phenotypes of gastric fundic gland polyposis and cancer in patients with familial adenomatous polyposis depending on Helicobacter pylori infection

A dose-escalation study of docetaxel, oxaliplatin, and S-1 (DOS) as a first-line therapy for patients with unresectable metastatic gastric cancer

Massive hemobilia following plastic stent removal in common bile duct cancer associated with primary sclerosing cholangitis (with video)

First report of an Asian family with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) revealed with the germline mutation of the APC exon 1B promoter region

Sa1984 - Near-Infrared Molecular Imaging of Gastrointestinal Stromal Tumors using a Novel Fluorescent Probe Indocyanine Green (ICG)-Labeled Dasatinib

Sa1209 - Clinicopathological Analyses of Colorectal Polyps and Cancers in Serrated Polyposis Syndrome

1027 - Mir-144-3P/451A as a Novel Biomarker for Predicting Recurrence and Metastasis in Rectal Neuroendocrine Tumors Through Targeting Pten/P19

APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism

A triplet combination with capecitabine/oxaliplatin/irinotecan (XELOXIRI) plus cetuximab as first-line therapy for patients with metastatic colorectal cancer: a dose escalation study

Sa1717 Detection of Aberrant Crypt Foci Using Image-Enhanced Endoscopy

Efficacy of hybrid endoscopic submucosal dissection (ESD) as a rescue treatment in difficult colorectal ESD cases

Optical Molecular Imaging of Aberrant Crypt Foci in the Human Colon by Glutathione S-Transferase-Activated Fluorogenic Probe

Usefulness of Linked Color Imaging System in Endoscopic Diagnosis of Sessile Serrated Adenoma/Polyp: A Novel Image Enhanced Technique

A New Theranostic Combination of Fluorescent Molecular Imaging and Laser Therapy Targeting C-Kit in Gastrointestinal Stromal Tumors

Duodenal cancer in a young patient with Peuts-Jeghers syndrome harboring an entire deletion of the STK11 gene

Clinicopathological characteristics of serrated polyps as precursors to colorectal cancer: Current status and management

Colon capsule endoscopy: toward the future

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