Search results for: Lian Cen

Items from 1 to 20 out of 25 results

article

Well‐Defined Poly(ethylene glycol) Hydrogels with Enhanced Mechanical Performance Prepared by Thermally Induced Copper‐Catalyzed Azide–Alkyne Cycloaddition

Ke Wen Li, Lian Cen, Chao Zhou, Ao Kai Zhang, more

Macromolecular Materials and Engineering > 301 > 11 > 1374 - 1382

Poly(ethylene glycol) (PEG)‐based hydrogels have attracted increasing attention in recent years due to their good biocompatibility and low cost. However, the PEG‐based hydrogels prepared by traditional methods exhibit a poor machinability due to their disordered network structure. Herein, the preparation of well‐defined PEG‐based hydrogel via a facile thermally induced copper‐catalyzed azide–alkyne...

article

Influence of abutment tooth position and adhesive point dimension on the rigidity of a dental trauma wire‐composite splint

Yuqing Zhu, Hui Chen, Lian Cen, Jun Wang

Dental Traumatology > 32 > 3 > 225 - 230

Background/AimThe influence of abutment tooth position and adhesive point dimension on rigidity of wire‐composite splints, used in dental trauma, was evaluated in vitro. Materials and MethodsA commercial artificial resin model was used. The central incisors served as injured teeth with increased mobility (degrees of loosening II tooth 21 and III tooth 11), whereas teeth 12/22 or teeth 13/23 served...

article

Hydrogels of chemically cross-linked and organ-metallic complexed interpenetrating PEG networks

Meng-jiao Dong, Shun-li Liu, Lin-hua Tan, Lian Cen, more

Chinese Journal of Polymer Science > 2016 > 34 > 5 > 637-648

The aim of the present work was to prepare a well-defined hydrogel of chemically cross-linked and organ-metallic complexed interpenetrating PEG networks. The hydrogel was synthesized via the reaction of copper(I)- catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC) with poly(ethylene glycol)-dopamine (PEG-DA) (“Click Chemistry”) followed by complexation with Fe³⁺ ions to crosslink the polymeric...

article

PDL regeneration via cell homing in delayed replantation of avulsed teeth

Wenting Zhu, Qian Zhang, Yang Zhang, Lian Cen, more

Journal of Translational Medicine > 2015 > 13 > 1 > 1-11

Background This study was aimed to investigate whether regeneration of periodontal ligament (PDL) like tissue could be promoted by stromal cell-derived factor-1 (SDF1) and bone morphogenetic protein-7 (BMP7) induced cell homing in delayed replantation of avulsed teeth. Methods Canine mandibular premolar teeth were first extracted and air-dried for 2 h followed by complete detachment of their PDL...

article

Guided bone regeneration with tripolyphosphate cross-linked asymmetric chitosan membrane

Shiqing Ma, Zhen Chen, Feng Qiao, Yingchun Sun, more

Journal of Dentistry > 2014 > 42 > 12 > 1603-1612

The objective of this study was to prepare a novel asymmetric chitosan guided bone regeneration (GBR) membrane, which is composed of a dense layer isolating the bone defect from the invasion of surrounding connective fibrous tissue and a loose layer which can improve cell adhesion and stabilize blood clots, thus guided bone regeneration.The chitosan membrane was fabricated through liquid nitrogen...

article

The synthesis of hydrogels with controlled distribution of polymer brushes in hydrogel network

YuWei Sun, Chao Zhou, AoKai Zhang, LiQun Xu, more

Applied Surface Science > 2014 > 320 > C > 818-828

Poly(ethylene glycol) (PEG) hydrogels with 3-dimensionally controlled well-defined poly(N-isopropylacrylamide) (poly(NIPAAm)) brushes were prepared by combined copper(I)-catalyzed azide-alkyne cycloaddition (“Click Chemistry”) and atom transfer radical polymerization (ATRP). The resulting hydrogels were presented as representatives with their detailed synthesis routes and characterization. H_PEG-S-poly(NIPAAm)...

article

Layer-by-layer self-assembly of minocycline-loaded chitosan/alginate multilayer on titanium substrates to inhibit biofilm formation

Hongbin Lv, Zhen Chen, Xiaoping Yang, Lian Cen, more

Journal of Dentistry > 2014 > 42 > 11 > 1464-1472

Bacteria adhesion and subsequent biofilm formation are primary causes of implant associated infection. The biofilm makes the bacteria highly resistant to the host defense and antimicrobial treatment. Antibacterial coatings on the surface of titanium implant can prevent biofilm formation effectively, but it is still a challenge to accomplish relatively long lasting antibacterial effects before wound...

article

Cryopreservation of tissue-engineered epithelial sheets in trehalose

Fanfan Chen, Wenjie Zhang, Wei Wu, Yuqing Jin, more

Biomaterials > 2011 > 32 > 33 > 8426-8435

Tissue-engineered epidermal membranes are useful for clinical wound healing. To facilitate these products in the clinic, optimized storage methods need to be developed. We studied the efficiency of extracellular trehalose at various concentrations for cryopreserving human tissue-engineered epidermal membranes compared with that of dimethyl-sulfoxide (DMSO) used by most organ banks for cryopreserving...

article

The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway

Huijie Gu, Fangfang Guo, Xiao Zhou, Lunli Gong, more

Biomaterials > 2011 > 32 > 29 > 7023-7033

Our previous study indicates that akermanite, a type of Ca-, Mg-, Si-containing bioceramic, can promote the osteogenic differentiation of hASCs. To elucidate the underlying mechanism, we investigated the effect of the extract from akermanite, on proliferation and osteogenic differentiation of hASCs. The original extract was obtained at 200 mg akermanite/ml LG-DMEM and further diluted with LG-DMEM...

article

Incorporation of tripolyphosphate nanoparticles into fibrous poly(lactide-co-glycolide) scaffolds for tissue engineering

Shujun Xie, Qin Zhu, Bin Wang, Huijie Gu, more

Biomaterials > 2010 > 31 > 19 > 5100-5109

Poly(lactide-co-glycolide) (PLGA) has been widely used for scaffolding materials in tissue engineering. It degrades mainly via hydrolysis of the ester bonds into lactic acid and glycolic acid leading to the decrease in pH of the surrounding microenvironment. The current study was designed to quickly neutralize the acidic degradation products of PLGA fibrous scaffolds by incorporating tripolyphosphate...

article

A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells

Chen Wang, Lian Cen, Shuo Yin, Qihai Liu, more

Biomaterials > 2010 > 31 > 4 > 621-630

Smooth muscle layer plays an important role in maintaining homeostasis of blood vessels, thus generating a functional smooth muscle layer is a prerequisite for successful construction of blood vessels via tissue-engineering approach. In this study, we investigated the feasibility of constructing an elastic vessel wall in small diameter (less than 6 mm) using smooth muscle cells (SMCs) differentiated...

article

Vitreous cryopreservation of tissue engineered bone composed of bone marrow mesenchymal stem cells and partially demineralized bone matrix

Hongyu Yin, Lei Cui, Guangpeng Liu, Lian Cen, more

Cryobiology > 2009 > 59 > 2 > 180-187

Cryopreservation of tissue engineered products by maintaining their structure and function is a prerequisite for large-scale clinical applications. In this study, we examined the feasibility of cryopreservation of tissue engineered bone (TEB) composed of osteo-induced canine bone marrow mesenchymal stem cells (cBMSCs) and partially demineralized bone matrix (pDBM) scaffold by vitrification. A novel...

article

In vitro engineering of fibrocartilage using CDMP1 induced dermal fibroblasts and polyglycolide

Guiqing Zhao, Shuo Yin, Guangpeng Liu, Lian Cen, more

Biomaterials > 2009 > 30 > 19 > 3241-3250

This study was designed to explore the feasibility of using cartilage-derived morphogenetic protein-1 (CDMP1) induced dermal fibroblasts (DFs) as seed cells and polyglycolide (PGA) as scaffold for fibrocartilage engineering. DFs isolated from canine were expanded and seeded on PGA scaffold to fabricate cell/scaffold constructs which were cultured with or without CDMP1. Proliferation and differentiation...

article

Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh

Lei Cui, Yaohao Wu, Lian Cen, Heng Zhou, more

Biomaterials > 2009 > 30 > 14 > 2683-2693

The current study was designed to observe chondrogenic differentiation of adipose derived stem cells (ASCs) on fibrous polyglycolic acid (PGA) scaffold stabilized with polylactic acid (PLA), and to further explore the feasibility of using the resulting cell/scaffold constructs to repair full thickness articular cartilage defects in non-weight bearing area in porcine model within a follow-up of 6 months...

article

A comparative study of proliferation and osteogenic differentiation of adipose-derived stem cells on akermanite and β-TCP ceramics

Qihai Liu, Lian Cen, Shuo Yin, Lei Chen, more

Biomaterials > 2008 > 29 > 36 > 4792-4799

This study investigated the in vitro effects of akermanite, a new kind of Ca-, Mg-, Si-containing bioceramic, on the attachment, proliferation and osteogenic differentiation of human adipose-derived stem cells (hASCs). Parallel comparison of the cellular behaviors of hASCs on the akermanite was made with those on beta-tricalcium phosphate (β-TCP). Scanning electron microscope (SEM) observation and...

article

Engineering of an elastic large muscular vessel wall with pulsatile stimulation in bioreactor

Zhi C. Xu, Wen J. Zhang, Hong Li, Lei Cui, more

Biomaterials > 2008 > 29 > 10 > 1464-1472

Tissue engineering offers a new approach for the construction of vascular substitutes in vitro with proper mechanical properties. Although success has been made in the engineering of small blood vessels (<6mm in diameter), it remains a challenge to engineer large vessels (>6mm in diameter) due to their insufficient biomechanical property. In the current study, an elastic large vessel wall (6mm...

article

Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model

Lei Cui, Bo Liu, Guangpeng Liu, Wenjie Zhang, more

Biomaterials > 2007 > 28 > 36 > 5477-5486

Adipose derived stem cells (ASCs) with osteogenic differentiation potential have been documented as an alternative cell source for bone regeneration. However, most of previous in vivo studies were carried out on small animals along with relatively short-term follow-up. In this study, we investigated the feasibility of using ASCs and coral scaffolds to repair a cranial bone defect in a canine model,...

article

Au–Pt bimetallic nanoparticles formation via viologen-mediated reduction on polymeric nanospheres

Lian Cen, K.G. Neoh, Qinjia Cai, E.T. Kang

Journal of Colloid And Interface Science > 2006 > 300 > 1 > 190-199

Poly(vinylbenzyl chloride) nanospheres prepared via emulsion polymerization were surface functionalized with viologen moieties. Several methods were investigated to achieve the desired high surface concentration of viologen moieties with minimal aggregation of the nanospheres. The viologen-functionalized nanospheres were used for photoinduced reduction of gold ions and platinum ions, either individually,...

article

Cellular Response to Magnetic Nanoparticles “PEGylated” via Surface-Initiated Atom Transfer Radical Polymerization

Hu, Koon Gee Neoh, Lian Cen, En-Tang Kang

Biomacromolecules > 2006 > 7 > 3 > 809 - 816

article

Porous and Electrically Conductive Polypyrrole−Poly(vinyl alcohol) Composite and Its Applications as a Biomaterial

Yali Li, K. G. Neoh, Lian Cen, E. T. Kang

Langmuir > 2005 > 21 > 23 > 10702 - 10709

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Search results for: Lian Cen

Well‐Defined Poly(ethylene glycol) Hydrogels with Enhanced Mechanical Performance Prepared by Thermally Induced Copper‐Catalyzed Azide–Alkyne Cycloaddition

Influence of abutment tooth position and adhesive point dimension on the rigidity of a dental trauma wire‐composite splint

Hydrogels of chemically cross-linked and organ-metallic complexed interpenetrating PEG networks

PDL regeneration via cell homing in delayed replantation of avulsed teeth

Guided bone regeneration with tripolyphosphate cross-linked asymmetric chitosan membrane

The synthesis of hydrogels with controlled distribution of polymer brushes in hydrogel network

Layer-by-layer self-assembly of minocycline-loaded chitosan/alginate multilayer on titanium substrates to inhibit biofilm formation

Cryopreservation of tissue-engineered epithelial sheets in trehalose

The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway

Incorporation of tripolyphosphate nanoparticles into fibrous poly(lactide-co-glycolide) scaffolds for tissue engineering

A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells

Vitreous cryopreservation of tissue engineered bone composed of bone marrow mesenchymal stem cells and partially demineralized bone matrix

In vitro engineering of fibrocartilage using CDMP1 induced dermal fibroblasts and polyglycolide

Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh

A comparative study of proliferation and osteogenic differentiation of adipose-derived stem cells on akermanite and β-TCP ceramics

Engineering of an elastic large muscular vessel wall with pulsatile stimulation in bioreactor

Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model

Au–Pt bimetallic nanoparticles formation via viologen-mediated reduction on polymeric nanospheres

Cellular Response to Magnetic Nanoparticles “PEGylated” via Surface-Initiated Atom Transfer Radical Polymerization

Porous and Electrically Conductive Polypyrrole−Poly(vinyl alcohol) Composite and Its Applications as a Biomaterial

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