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The regeneration of whole osteochondral constructs with a physiological structure has been a significant issue, both clinically and academically. In this study, we present a method using rabbit bone marrow stromal cells (BMSCs) cultured on a silk–RADA peptide scaffold in a specially designed two‐chambered co‐culture well for the generation of multilayered osteochondral constructs in vitro. This specially...
Hybrid silk scaffolds combining knitted silk fibers and silk sponge have been recently developed for use as ligament‐alone grafts. Incorporating an osteoinductive phase into the ends of a ligament scaffold may potentially generate an integrated “bone–ligament–bone” graft and improve graft osteointegration with host bone. To explore the possible application of hydroxyapatite (HA) coating in the fabrication...
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