Search results for: Kimberly Frost-Pineda

Items from 1 to 11 out of 11 results

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Factors affecting exposure to nicotine and carbon monoxide in adult cigarette smokers

Raheema Muhammad-Kah, Qiwei Liang, Kimberly Frost-Pineda, Paul E. Mendes, more

Regulatory Toxicology and Pharmacology > 2011 > 61 > 1 > 129-136

Exposure to cigarette smoke among smokers is highly variable. This variability has been attributed to differences in smoking behavior as measured by smoking topography, as well as other behavioral and subjective aspects of smoking. The objective of this study was to determine the factors affecting smoke exposure as estimated by biomarkers of exposure to nicotine and carbon monoxide (CO). In a multi-center...

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The relationship between nicotine dependence scores and biomarkers of exposure in adult cigarette smokers

Raheema S. Muhammad-Kah, Angela D. Hayden, Qiwei Liang, Kimberly Frost-Pineda, more

Regulatory Toxicology and Pharmacology > 2011 > 60 > 1 > 79-83

Background: Tobacco dependence is a multidimensional phenomenon. The Fagerström Test for Nicotine Dependence (FTND) is a widely administered six-item questionnaire used as a measure of nicotine dependence. It has been suggested that this test may not represent the entire spectrum of factors related to dependence. Also the relationship of this test with biomarkers of exposure to cigarette smoke has...

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The relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the US

Paul Mendes, Qiwei Liang, Kimberly Frost-Pineda, Sagar Munjal, more

Regulatory Toxicology and Pharmacology > 2009 > 55 > 1 > 17-27

Comprehensive data on human exposure to smoke constituents from different machine-measured tar yield cigarettes is limited. Methods: This study used a stratified, cross-sectional, multi-center design to estimate biomarkers of exposure (BOE) from nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), pyrene, CO, acrolein, and 1,3-butadiene and their relationship to tar yield categories of...

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Environmental tobacco smoke (ETS) evaluation of a third-generation electrically heated cigarette smoking system (EHCSS)

Kimberly Frost-Pineda, Barbara K. Zedler, Qiwei Liang, Hans J. Roethig

Regulatory Toxicology and Pharmacology > 2008 > 52 > 2 > 118-121

This sub-study of a randomized, controlled, forced-switching, open-label, parallel-group, clinical study compared environmental tobacco smoke (ETS) produced when 60 male and female adult smokers switched to a third-generation electrically heated cigarette smoking system (EHCSS), continued to smoke a conventional cigarette (CC), or stopped smoking (No-smoking). Concentrations of air constituents including...

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Short-term clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers

Kimberly Frost-Pineda, Barbara K. Zedler, Douglas Oliveri, Shixia Feng, more

Regulatory Toxicology and Pharmacology > 2008 > 52 > 2 > 104-110

This randomized, controlled, forced-switching, open-label, parallel-group, single-center study in 100 male and female adult smokers evaluated 12 biomarkers of tobacco smoke exposure. We measured exposure to the following smoke constituents: nicotine, pyrene, tobacco-specific nitrosamines, three aromatic amines, carbon monoxide, benzene, acrolein, crotonaldehyde, and 1,3-butadiene. After baseline exposure...

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12-Week clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers

Kimberly Frost-Pineda, Barbara K. Zedler, Douglas Oliveri, Qiwei Liang, more

Regulatory Toxicology and Pharmacology > 2008 > 52 > 2 > 111-117

This randomized, controlled, forced-switching, open-label, parallel-group, single-center study in 90 male and female adult smokers evaluated six biomarkers of tobacco smoke exposure over a 12-week period of unrestricted smoking in the participants’ normal life setting. Baseline biomarker levels were measured, then participants were randomly assigned to switch to an electrically heated cigarette smoking...

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Regarding “Is Cigarette Smoking a Gateway to Alcohol and Illicit Drug Use Disorders? A Study of Youths with and without Attention Deficit Hyperactivity Disorder”

Mark S. Gold, Kimberly Frost-Pineda

Biological Psychiatry > 2006 > 60 > 10 > 1166

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Physicians and Drug Screening

Mark S. Gold, Kimberly Frost-Pineda, Bruce A. Goldberger, Robert L. DuPont

Journal of Adolescent Health > 2006 > 39 > 2 > 154-155

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Is Speeding a Form of Gambling in Adolescents?

David S. Husted, Mark S. Gold, Kimberly Frost- Pineda, Mary A. Ferguson, more

Journal of Gambling Studies > 2006 > 22 > 2 > 209-219

Speeding is a major contributor to motor vehicle accidents, which are the leading cause of death in adolescents. This study compares the extent to which adolescents with gambling behavior and substance use reported driving over the posted speed limits (“speeding”). Florida adolescents ages 13–17 (n = 1051) were surveyed, and asked about gambling activities, problems related to gambling, substance...

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Second-hand exposure to aerosolized intravenous anesthetics propofol and fentanyl may cause sensitization and subsequent opiate addiction among anesthesiologists and surgeons

Priscilla F. McAuliffe, Mark S. Gold, Lakshmikant Bajpai, Michele L. Merves, more

Medical Hypotheses > 2006 > 66 > 5 > 874-882

We hypothesize that aerosolization of anesthetics administered intravenously to patients in the operating room may be an unintended source of exposure to physicians. This may lead to inadvertent sensitization, which is associated with an increased risk for developing addiction. This may contribute to the over-representation of certain specialties among physicians with addiction.We retrospectively...