Search results for: Colleen S. Kraft

Items from 1 to 19 out of 19 results

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Characterization of Ebola convalescent plasma donor immune response and psoralen treated plasma in the United States

Christina L. Dean, Jay W. Hooper, John M. Dye, Samantha E. Zak, more

BACKGROUND In 2014, passive immunization by transfusion of Ebola convalescent plasma (ECP) was considered for treating patients with acute Ebola virus disease (EVD). Early Ebola virus (EBOV) seroconversion confers a survival advantage in natural infection, hence transfusion of ECP plasma with high levels of neutralizing EBOV antibodies is a potential passive immune therapy. Techniques to reduce the...

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Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience

Yao‐Wen Cheng, Emmalee Phelps, Vincent Ganapini, Noor Khan, more

American Journal of Transplantation > 19 > 2 > 501 - 511

Fecal microbiota transplant (FMT) is recommended for Clostridium difficile infection (CDI) treatment; however, use in solid organ transplantation (SOT) patients has theoretical safety concerns. This multicenter, retrospective study evaluated FMT safety, effectiveness, and risk factors for failure in SOT patients. Primary cure and overall cure were defined as resolution of diarrhea or negative C difficile...

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Tacrolimus concentration to dose ratio in solid organ transplant patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection

Michael H. Woodworth, Colleen S. Kraft, Erika J. Meredith, Aneesh K. Mehta, more

Transplant Infectious Disease > 20 > 2 > n/a - n/a

Fecal microbiota transplantation (FMT) is increasingly being performed for Clostridium difficile infection in solid organ transplant (SOT) patients; however, little is known about the potential pharmacokinetic or pharmacomicrobial effects this may have on tacrolimus levels. We reviewed the medical records of 10 SOT patients from September 2012‐December 2016 who were taking tacrolimus at time of FMT...

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Performance evaluation of the Aptima HSV-1 and 2 assay for the detection of HSV in cutaneous and mucocutaneous lesion specimens

Soya S. Sam, Angela M. Caliendo, Jessica Ingersoll, Deborah Abdul-Ali, more

Journal of Clinical Virology > 2018 > 99-100 > C > 1-4

Timely and precise laboratory diagnosis of Herpes simplex viruses (HSV) is required to guide clinical management.The study evaluated limit of detection (LOD) and performance characteristics of the Aptima HSV 1 & 2 assay in comparison to four assays.The multi-center study compared qualitative detection of HSV-1 and 2 by the Aptima HSV-1 and 2 assay (Hologic) to ELVIS culture, Lyra Direct (Quidel),...

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Risk factors and epidemiology of Clostridium difficile infection in hematopoietic stem cell transplant recipients during the peritransplant period

Sol del Mar Aldrete, Colleen S. Kraft, Matthew J. Magee, Austin Chan, more

Transplant Infectious Disease > 19 > 1 > n/a - n/a

Background Hematopoietic stem cell transplant (HSCT) recipients represent a high‐risk group for developing Clostridium difficile (CD) infection (CDI). We aimed to identify specific risk factors for CDI in an HSCT patient population during the peritransplant period. Methods We performed a case–control study within a cohort of HSCT patients who received a transplant from November 2010 to March 2013...

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Long-term Management of Panuveitis and Iris Heterochromia in an Ebola Survivor

Jessica G. Shantha, Ian Crozier, Jay B. Varkey, Colleen S. Kraft, more

Ophthalmology > 2016 > 123 > 12 > 2626-2628.e2

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Overlooking the importance of immunoassays – Authors' reply

Lieselotte Cnops, Johan van Griensven, Anna N Honko, Daniel G Bausch, more

The Lancet Infectious Diseases > 2016 > 16 > 10 > 1110

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Intestinal microbiome disruption in patients in a long-term acute care hospital: A case for development of microbiome disruption indices to improve infection prevention

Alison Laufer Halpin, Tom J.B. de Man, Colleen S. Kraft, K. Allison Perry, more

American Journal of Infection Control > 2016 > 44 > 7 > 830-836

Composition and diversity of intestinal microbial communities (microbiota) are generally accepted as a risk factor for poor outcomes; however, we cannot yet use this information to prevent adverse outcomes.Stool was collected from 8 long-term acute care hospital patients experiencing diarrhea and 2 fecal microbiota transplant donors; 16S rDNA V1-V2 hypervariable regions were sequenced. Composition...

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Essentials of filoviral load quantification

Lieselotte Cnops, Johan van Griensven, Anna N Honko, Daniel G Bausch, more

The Lancet Infectious Diseases > 2016 > 16 > 7 > e134-e138

Quantitative measurement of viral load is an important parameter in the management of filovirus disease outbreaks because viral load correlates with severity of disease, survival, and infectivity. During the ongoing Ebola virus disease outbreak in parts of Western Africa, most assays used in the detection of Ebola virus disease by more than 44 diagnostic laboratories yielded qualitative results. Regulatory...

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Molecular epidemiology of norovirus in children and the elderly in Atlanta, Georgia, United States

Jumi Yi, Kelly Wahl, Bethany K. Sederdahl, Robert R. Jerris, more

Journal of Medical Virology > 88 > 6 > 961 - 970

Noroviruses are an important cause of gastroenteritis, which can be severe at the extremes of ages. Data documenting the endemic burden of norovirus among children and elderly adults are lacking. Stool specimens submitted for clinical testing were collected from elderly (≥65 years) adults and children (<18 years) with acute vomiting and/or diarrhea seeking care at several metropolitan Atlanta adult...

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Successful treatment of chronic Pouchitis utilizing fecal microbiota transplantation (FMT): a case report

Shuyang Fang, Colleen S. Kraft, Tanvi Dhere, Jahnavi Srinivasan, more

International Journal of Colorectal Disease > 2016 > 31 > 5 > 1093-1094

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Fecal transplant is as effective and safe in immunocompromised as non-immunocompromised patients for Clostridium difficile

Amar Mandalia, Angela Ward, William Tauxe, Colleen S. Kraft, more

International Journal of Colorectal Disease > 2016 > 31 > 5 > 1059-1060

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Fatal aortic pseudoaneurysm from disseminated Mycobacterium kansasii infection: case report

Laleh Ehsani, Sujan C. Reddy, Mario Mosunjac, Colleen S. Kraft, more

Human Pathology > 2015 > 46 > 3 > 467-470

Mycobacterium kansasii is a photochromogenic, slow-growing mycobacterium species that can cause pulmonary infection in patients with predisposing lung diseases, as well as extrapulmonary or disseminated disease in immunosuppressed patients. We describe a patient with a myelodysplastic syndrome, disseminated M kansasii infection, and ruptured aortic aneurysm. He had a recent diagnosis of mycobacterium...

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Sa1288 Outcomes for Route and Immunocompromised Status Do Not Significantly Differ in Fecal Microbiota Transplant for Recurrent Clostridium difficile

Amar Mandalia, Angela Ward, Colleen S. Kraft, Tanvi A. Dhere

Gastroenterology > 2014 > 146 > 5 Supplement 1 > S-252-S-253

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A NOVEL IMAGING PROBE FOR THE DETECTION OF SUBCLINICAL BACTERIAL INFECTIONS INVOLVING CARDIAC DEVICES

Kiyoko Takemiya, Niren Murthy, Wone Woo Seo, Xinghai Ning, more

Journal of the American College of Cardiology > 2014 > 63 > 12(S) > A2146

article

Interpreting Laboratory Results in Transgender Patients on Hormone Therapy

Tiffany K. Roberts, Colleen S. Kraft, Deborah French, Wuyang Ji, more

The American Journal of Medicine > 2014 > 127 > 2 > 159-162

Clinical guidelines recommend laboratory monitoring of transgender persons on cross-sex hormone therapy, but gender-specific reference intervals leave clinicians with the dilemma of deciding what is “normal” for each patient. The goal of this study was to identify consistent changes in measurands with hormone therapy and determine which reference interval is appropriate.Laboratory data were abstracted...

article

Successful use of Plasma Preparation Tubes™ (PPTs) in the COBAS® AmpliPrep/COBAS® TaqMan® HIV-1 Test

Colleen S. Kraft, José Nilo G. Binongo, Eileen M. Burd, Molly E. Eaton, more

Journal of Clinical Virology > 2013 > 57 > 1 > 77-79

Since switching to the COBAS ^® AmpliPrep/COBAS ^® TaqMan ^® HIV-1 Test, v. 1.0 from the Amplicor HIV-1 Monitor Test, v. 1.5, an increase in detectable viral load results was noted. We were concerned that this was due to the use of Plasma Preparation Tubes (PPT) in this test.To assess the impact of different pre-analytical processing conditions on HIV-1 viral load results on the...

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Pichia anomala (Candida pelliculosa) Fungemia in a Patient with Sickle Cell Disease

Austin W. Chan, Emily J. Cartwright, Sujan C. Reddy, Colleen S. Kraft, more

Mycopathologia > 2013 > 176 > 3-4 > 273-277

This case report discusses a patient with sickle cell disease who presented with fungemia from Pichia anomala (teleomorph: Candida pelliculosa). The organism was identified as P. anomala by MALDI-TOF VITEK mass spectrometry and VITEK 2 yeast identification card. Pichia anomala should be considered in sickle cell patients with recurrent fungemia.

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Cytomegalovirus DNA stability in EDTA anti-coagulated whole blood and plasma samples

Deborah Abdul-Ali, Colleen S. Kraft, Jessica Ingersoll, Mona Frempong, more

Journal of Clinical Virology > 2011 > 52 > 3 > 222-224

Cytomegalovirus (CMV) DNA viral load testing is routinely performed in centers that serve patients that are immunosuppressed from organ or hematopoietic stem cell transplantation. Clinical laboratories that offer this testing often face practical concerns about the storage of these specimens to ensure accurate measurement for patient care. The published studies that assess CMV DNA stability at 4°C...

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