Search results for: Andreas M. Hötker

Items from 1 to 19 out of 19 results

article

MRI Characteristics of Pediatric Renal Tumors: A SIOP‐RTSG Radiology Panel Delphi Study

Justine N. Beek, Tom A. Watson, Rutger A.J. Nievelstein, Hervé J. Brisse, more

Journal of Magnetic Resonance Imaging > 55 > 2 > 543 - 552

Background The SIOP‐Renal Tumor Study Group (RTSG) does not advocate invasive procedures to determine histology before the start of therapy. This may induce misdiagnosis‐based treatment initiation, but only for a relatively small percentage of approximately 10% of non‐Wilms tumors (non‐WTs). MRI could be useful for reducing misdiagnosis, but there is no global consensus on differentiating characteristics...

article

Novel morphological and genetic features of fumarate hydratase deficient renal cell carcinoma in HLRCC syndrome patients with a tailored therapeutic approach

Nicolas Wyvekens, Nadejda Valtcheva, Axel Mischo, Birgit Helmchen, more

Genes, Chromosomes and Cancer > 59 > 11 > 611 - 619

The hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC) is defined by germline mutations in the fumarate hydratase (FH) gene and associated with leiomyomas and aggressive renal cell carcinomas with FH deficiency. Here, we comprehensively characterize two new patients with HLRCC syndrome on a morphological, immunohistochemical and genetic level. The patients developed aggressive HLRCC...

article

Pelvic MRI after induction chemotherapy and before long-course chemoradiation therapy for rectal cancer: What are the imaging findings?

Marc J. Gollub, Ivana Blazic, David D. B. Bates, Naomi Campbell, more

European Radiology > 2019 > 29 > 4 > 1733-1742

Objectives To determine the appearance of rectal cancer on MRI after oxaliplatin-based chemotherapy (ICT) and make a preliminary assessment of MRI’s value in predicting response to total neoadjuvant treatment (TNT). Methods In this IRB-approved, HIPAA-compliant, retrospective study between 1 January 2010–20 October 2014, pre- and post-ICT tumour T2 volume, relative T2 signal intensity (rT2SI), node...

article

Temporal changes in MRI appearance of the prostate after focal ablation

Andreas M. Hötker, Andreas Meier, Yousef Mazaheri, Junting Zheng, more

Abdominal Radiology > 2019 > 44 > 1 > 272-278

Purpose The purpose of our study was to retrospectively evaluate and categorize temporal changes in MRI appearances of the prostate in patients who underwent focal therapy with MRI follow-up. Methods The Institutional Review Board approved this retrospective study and waived the requirement for informed consent. Thirty-seven patients (median age 61; 48–70 years) with low-to-intermediate-risk, clinically...

article

Model selection for high b-value diffusion-weighted MRI of the prostate

Yousef Mazaheri, Andreas M. Hötker, Amita Shukla-Dave, Oguz Akin, more

Magnetic Resonance Imaging > 2018 > 46 > C > 21-27

To assess the abilities of the standard mono-exponential (ME), bi-exponential (BE), diffusion kurtosis (DK) and stretched exponential (SE) models to characterize diffusion signal in malignant and prostatic tissues and determine which of the four models best characterizes these tissues on a per-voxel basis.This institutional-review-board-approved, HIPAA-compliant, retrospective study included 55 patients...

article

Quantitating whole lesion tumor biology in rectal cancer MRI: taking a lesson from FDG-PET tumor metrics

Marc J. Gollub, Andreas M. Hotker, Kaitlin M. Woo, Yousef Mazaheri, more

Abdominal Radiology > 2018 > 43 > 7 > 1575-1582

Purpose To determine the value of novel whole tumor metrics in DWI-MRI and DCE-MRI of rectal cancer treatment assessment. Materials and methods This retrospective study included 24 uniformly treated patients with rectal adenocarcinoma who underwent MRI including diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) sequences, before and after chemoradiotherapy. Two experienced readers independently...

article

The value of advanced MRI techniques in the assessment of cervical cancer: a review

Evelyn Dappa, Tania Elger, Annette Hasenburg, Christoph Düber, more

Insights into Imaging > 2017 > 8 > 5 > 471-481

Objectives To assess the value of new magnetic resonance imaging (MRI) techniques in cervical cancer. Methods We searched PubMed and MEDLINE and reviewed articles published from 1990 to 2016 to identify studies that used MRI techniques, such as diffusion weighted imaging (DWI), intravoxel incoherent motion (IVIM) and dynamic contrast enhancement (DCE) MRI, to assess parametric invasion, to detect...

article

MP55-08 DIAGNOSIS, MANAGEMENT, AND CLINICAL OUTCOMES OF CYSTIC RENAL CELL CARCINOMA

Mahyar Kashan, Mazyar Ghanaat, Maria Becerra, Andreas M. Hötker, more

The Journal of Urology > 2017 > 197 > 4(S) > e733

article

MP55-01 MIXED EPITHELIAL AND STROMAL TUMOR FAMILY: A SINGLE INSTITUTIONAL EXPERIENCE WITH THIS RARE RENAL ENTITY

Mahyar Kashan, Mazyar Ghanaat, Maria Becerra, Andreas M. Hötker, more

The Journal of Urology > 2017 > 197 > 4(S) > e730

article

The performance of PI-RADSv2 and quantitative apparent diffusion coefficient for predicting confirmatory prostate biopsy findings in patients considered for active surveillance of prostate cancer

Stephanie Nougaret, Nicola Robertson, Jennifer Golia Pernicka, Nicolas Molinari, more

Abdominal Radiology > 2017 > 42 > 7 > 1968-1974

Purpose To assess the performance of the updated Prostate Imaging Reporting and Data System (PI-RADSv2) and the apparent diffusion coefficient (ADC) for predicting confirmatory biopsy results in patients considered for active surveillance of prostate cancer (PCA). Methods IRB-approved, retrospective study of 371 consecutive men with clinically low-risk PCA (initial biopsy Gleason score ≤6, prostate-specific...

chapter

Improved noninvasive prostate cancer assessment using multiparametric magnetic resonance imaging

Xia Li, Asha Singanamalli, Dattesh Shanbhag, Andreas M. Hotker, more

2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI) > 1199 - 1203

2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI 2016)

This study explores potential multi-parametric magnetic resonance imaging (mpMRI) biomarkers for improved non-invasive prostate cancer (PCa) management, particularly for clinically significant PCa lesions that are missed by the current standard of care mpMRI exams. T2-weighted MRI and diffusion weighted imaging scans were acquired for subjects with Gleason Score 6 to 9 PCa lesions prior to radical...

article

Multiparametric MRI in the assessment of response of rectal cancer to neoadjuvant chemoradiotherapy: A comparison of morphological, volumetric and functional MRI parameters

Andreas M. Hötker, Lisa Tarlinton, Yousef Mazaheri, Kaitlin M. Woo, more

European Radiology > 2016 > 26 > 12 > 4303-4312

Purpose To compare morphological and functional MRI metrics and determine which ones perform best in assessing response to neoadjuvant chemoradiotherapy (CRT) in rectal cancer. Materials and methods This retrospective study included 24 uniformly-treated patients with biopsy-proven rectal adenocarcinoma who underwent MRI, including diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) sequences,...

article

Bevacizumab Monotherapy as Salvage Therapy for Advanced Clear Cell Renal Cell Carcinoma Pretreated With Targeted Drugs

Chung-Han Lee, Andreas M. Hötker, Martin H. Voss, Darren R. Feldman, more

Clinical Genitourinary Cancer > 2016 > 14 > 1 > 56-62

Bevacizumab has shown benefit in the first-line treatment of metastatic clear cell renal cell carcinoma (ccRCC) in combination with interferon α. In this retrospective analysis we assessed the efficacy of bevacizumab monotherapy in patients whose disease progressed during treatment with vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors, and/or mammalian target of rapamycin...

article

Subcentimeter Pulmonary Nodules are Not Associated with Disease Progression in Patients with Renal Cell Carcinoma

Roy Mano, Emily Vertosick, Alexander I. Sankin, Michael S. Chevinsky, more

The Journal of Urology > 2015 > 193 > 3 > 776-782

Renal cell carcinoma most commonly metastasizes to the lung. Indeterminate pulmonary nodules develop preoperatively in half of the patients with localized renal cell carcinoma but clinical significance remains poorly defined. We determined whether the presence of indeterminate pulmonary nodules, or nodule size or number is associated with renal cell carcinoma outcomes.We reviewed data on 1,102 patients...

article

Prostate Cancer: assessing the effects of androgen-deprivation therapy using quantitative diffusion-weighted and dynamic contrast-enhanced MRI

Andreas M. Hötker, Yousef Mazaheri, Junting Zheng, Chaya S. Moskowitz, more

European Radiology > 2015 > 25 > 9 > 2665-2672

Purpose To investigate the effects of androgen-deprivation therapy (ADT) on MRI parameters and evaluate their associations with treatment response measures. Materials and methods The study included 30 men with histopathologically confirmed prostate cancer who underwent MRI before and after initiation of ADT. Thirty-four tumours were volumetrically assessed on DW-MRI (n = 32) and DCE-MRI (n = 18),...

article

Interreader and inter-test agreement in assessing treatment response following transarterial embolization for hepatocellular carcinoma

Olivio F. Donati, Richard Kinh Gian Do, Andreas M. Hötker, Seth S. Katz, more

European Radiology > 2015 > 25 > 9 > 2779-2788

Purpose To evaluate interreader and inter-test agreement in applying size- and necrosis-based response assessment criteria after transarterial embolization (TAE) for hepatocellular carcinoma (HCC), applying two different methods of European Association for the Study of the Liver (EASL) criteria. Methods Seventy-four patients (median age, 67 years) from a prospectively accrued study population were...

article

Dynamic contrast enhanced‐MRI in rectal cancer: Inter‐ and intraobserver reproducibility and the effect of slice selection on pharmacokinetic analysis

Andreas M. Hötker, Irene Schmidtmann, Katja Oberholzer, Christoph Düber

Journal of Magnetic Resonance Imaging > 40 > 3 > 715 - 722

PurposeTo assess inter‐ and intraobserver reproducibility of DCE‐MRI measurements and possible differences between two directly adjacent slices. Materials and MethodsDCE‐MRI measurements of 30 patients with histologically proven rectal carcinoma were performed on a 1.5 Tesla (T) MR system during intravenous contrast agent application before and after neoadjuvant radiochemotherapy with two directly...

article

Speech and motion control for interventional radiology: requirements and feasibility

Andreas M. Hötker, Michael B. Pitton, Peter Mildenberger, Christoph Düber

International Journal of Computer Assisted Radiology and Surgery > 2013 > 8 > 6 > 997-1002

Purpose Interventional radiology is performed in a sterile environment where speech and motion control of image review is needed to simplify and expedite routine procedures. The requirements and limitations were defined by testing an interventional radiology test bed speech and motion control system. Methods Motion control software was implemented using the Microsoft $$^{\circledR }$$ Kinect...

article

Rectal Cancer: Mucinous Carcinoma on Magnetic Resonance Imaging Indicates Poor Response to Neoadjuvant Chemoradiation

Katja Oberholzer, Matthias Menig, Andreas Kreft, Astrid Schneider, more

International Journal of Radiation Oncology, Biology, Physics > 2012 > 82 > 2 > 842-848

To assess response of locally advanced rectal carcinoma to chemoradiation with regard to mucinous status and local tumor invasion found at pretherapeutic magnetic resonance imaging (MRI).A total of 88 patients were included in this prospective study of patients with advanced mrT3 and mrT4 carcinomas. Carcinomas were categorized by MRI as mucinous (mucin proportion >50% within the tumor volume),...

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Search results for: Andreas M. Hötker

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