Search results for: Jens Hannibal

Items from 1 to 20 out of 46 results

article

Larger interface area at the human myotendinous junction in type 1 compared with type 2 muscle fibers

Jens Rithamer Jakobsen, Abigail Louise Mackey, Manuel Koch, Thomas Imhof, more

Scandinavian Journal of Medicine & Science in Sports > 33 > 2 > 136 - 145

The myotendinous junction (MTJ) is structurally specialized to transmit force. The highly folded muscle membrane at the MTJ increases the contact area between muscle and tendon and potentially the load tolerance of the MTJ. Muscles with a high content of type II fibers are more often subject to strain injury compared with muscles with type I fibers. It is hypothesized that this is explained by a smaller...

article

Prevention of retinal ganglion cell death by GPR81 agonist treatment

Rupali Vohra, Anna Luna Mølgaard Tams, Berta Sanz Morello, Zaynab Ahmad Mouhammad, more

Acta Ophthalmologica > 100 > S267 > n/a - n/a

Purpose Retinal ganglion cell (RGC) death is a common characteristic for ocular neurodegenerative diseases such as glaucoma and optic neuropathies. Recently, GPR81 agonist treatment has been identified as a key modulator of mitochondrial function and cell survival. Thus, we aimed to test whether GPR81 agonist treatment likewise promotes RGC survival and energy metabolism in retinal explants and wholemounts...

article

Decreased glucose metabolism and glutamine synthesis in the retina of a transgenic mouse model of Alzheimer’s disease

Anna Luna Mølgaard Tams, Berta Sanz Morello, Emil Winther Westi, Zaynab Ahmad Mouhammad, more

Acta Ophthalmologica > 100 > S267 > n/a - n/a

Purpose Visual changes are some of the earliest symptoms that patients with Alzheimer’s disease (AD) experience¹. Pathophysiological processes such as amyloid‐β plaque formation, vascular changes, neuroinflammation, and loss of retinal ganglion cells (RGCs) have been detected in the retina of AD patients and animal models¹. However, little is known about the molecular processes that underlie retinal...

article

Pituitary adenylate cyclase‐activating peptide: Potential roles in the pathophysiology and complications of cirrhosis

Mads Barloese, Mohammadnavid Chitgar, Jens Hannibal, Søren Møller

Liver International > 40 > 11 > 2578 - 2589

Pituitary adenylate cyclase‐activating peptide (PACAP) is a ubiquitous neuropeptide with diverse functions throughout the organism. Most abundantly investigated for its role in several neurological disorders as well as in circadian rhythms, other fields of medicine, including cardiology, have recently shown interest in the role of PACAP and its potential as a biomarker. Timely diagnosis and treatment...

article

Spatiotemporal expression pattern of PERIOD 1 and PERIOD 2 in the mouse SCN is dependent on VIP receptor 2 signaling

Jens Hannibal, Tania H. B. Norn, Birgitte Georg, Jan Fahrenkrug

European Journal of Neuroscience > 50 > 7 > 3115 - 3132

Neurons of the hypothalamic suprachiasmatic nucleus (SCN) express clock genes, which regulate their own transcription and generate daily output signals driving circadian rhythmic behavior and physiology. The neuropeptide VIP and its specific receptor, the VPAC2 receptor, are important for synchronization of clock neurons. In the present study, we characterized PER1 and PER2 expressing neurons in wild‐type...

article

Cover Image, Volume 526, Issue 12

Anders Tolstrup Christiansen, Jens Folke Kiilgaard, Kristian Klemp, David Paul Drucker Woldbye, more

Journal of Comparative Neurology > 526 > 12 > C1 - C1

The cover image, by Anders Tolstrup Christiansen et al., is based on the Research Article Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas—A comparative study, DOI: 10.1002/cne.24455.

article

Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas—A comparative study

Anders Tolstrup Christiansen, Jens Folke Kiilgaard, Kristian Klemp, David Paul Drucker Woldbye, more

Journal of Comparative Neurology > 526 > 12 > 1877 - 1895

Neuropeptide Y (NPY) is a peptide neurotransmitter abundantly expressed in the mammalian retina. Since its discovery, NPY has been studied in retinas of several species, but detailed characterization of morphology, cell‐type, and connectivity has never been conducted in larger mammals including humans and pigs. As the pig due to size and cellular composition is a well‐suited animal for retinal research,...

article

Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature

Casper Schwartz Riedel, Birgitte Georg, Henrik L. Jørgensen, Jens Hannibal, more

Journal of Molecular Neuroscience > 2018 > 64 > 1 > 9-19

Early growth response transcription factor 1 (EGR1) is expressed in the suprachiasmatic nucleus (SCN) after light stimulation. We used EGR1-deficient mice to address the role of EGR1 in the clock function and light-induced resetting of the clock. The diurnal rhythms of expression of the clock genes BMAL1 and PER1 in the SCN were evaluated by semi-quantitative in situ hybridization. We found no difference...

article

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always

Birgitte Georg, Anna Ghelli, Carla Giordano, Fred N. Ross-Cisneros, more

Mitochondrion > 2017 > 36 > C > 77-84

Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different...

article

Wavy multistratified amacrine cells in the monkey retina contain immunoreactive secretoneurin

Andrea S. Bordt, Ye Long, Nobuo Kouyama, Elizabeth S. Yamada, more

Peptides > 2017 > 94 > C > 33-42

The goals of this study were to describe the morphology, neurotransmitter content and synaptic connections of neurons in primate retinas that contain the neuropeptide secretoneurin. Amacrine cells were labeled with antibodies to secretoneurin in macaque and baboon retinas. Their processes formed three distinct plexuses in the inner plexiform layer: one in the outermost stratum, one in the center and...

article

Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity

Jens Hannibal, Anders Tolstrup Christiansen, Steffen Heegaard, Jan Fahrenkrug, more

Journal of Comparative Neurology > 525 > 8 > 1934 - 1961

Intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin belong to a heterogenic population of RGCs which regulate the circadian clock, masking behavior, melatonin suppression, the pupillary light reflex, and sleep/wake cycles. The different functions seem to be associated to different subtypes of melanopsin cells. In rodents, subtype classification has associated...

article

Melanopsin retinal ganglion cell loss in Alzheimer disease

Chiara La Morgia, Fred N. Ross‐Cisneros, Yosef Koronyo, Jens Hannibal, more

Annals of Neurology > 79 > 1 > 90 - 109

ObjectiveMelanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We investigated mRGCs in AD, hypothesizing that they contribute to circadian dysfunction. MethodsWe assessed retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) in 21 mild‐moderate AD patients, and in...

article

The Light‐Induced FOS Response in Melanopsin Expressing HEK‐293 Cells is Correlated with Melanopsin Quantity and Dependent on Light Duration and Irradiance

Birgitte Georg, Lene Rask, Jens Hannibal, Jan Fahrenkrug

Photochemistry and Photobiology > 90 > 5 > 1069 - 1076

We established a cell line (HEK‐hMel) expressing melanopsin in a tetracycline dependent manner to elucidate new aspects of melanopsin's light response. Different light stimuli were evaluated using FOS expression as response parameter. Immunoblotting was used to evaluate expression of melanopsin and FOS and qPCR to quantify FOS mRNA responses. The magnitude of the FOS response was found to correlate...

article

Differential expression of melanopsin mRNA and protein in Brown Norwegian rats

Jens Hannibal, Birgitte Georg, Jan Fahrenkrug

Experimental Eye Research > 2013 > 106 > Complete > 55-63

Melanopsin is expressed in a subpopulation of retinal ganglion cells rendering these cells intrinsically photosensitive (ipRGCs). The ipRGCs are the primary RGCs mediating light entrainment of the circadian clock and control of the pupillary light reflex, light regulated melatonin secretion and negative masking behaviour. Previous studies have demonstrated that melanopsin expression in albino rats...

article

Circadian rhythms and food anticipatory behavior in Wfs1-deficient mice

Hendrik Luuk, Jan Fahrenkrug, Jens Hannibal

Biochemical and Biophysical Research Communications > 2012 > 424 > 4 > 717-723

The dorsomedial hypothalamic nucleus (DMH) has been proposed as a candidate for the neural substrate of a food-entrainable oscillator. The existence of a food-entrainable oscillator in the mammalian nervous system was inferred previously from restricted feeding-induced behavioral rhythmicity in rodents with suprachiasmatic nucleus lesions. In the present study, we have characterized the circadian...

article

Altered pupillary light reflex in PACAP receptor 1-deficient mice

Anna Engelund, Jan Fahrenkrug, Adrian Harrison, Hendrik Luuk, more

Brain Research > 2012 > 1453 > Complete > 17-25

The pupillary light reflex (PLR) is regulated by the classical photoreceptors, rods and cones, and by intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin. IpRGCs receive input from rods and cones and project to the olivary pretectal nucleus (OPN), which is the primary visual center involved in PLR. Mice lacking either the classical photoreceptors or...

article

Altered Rhythm of Adrenal Clock Genes, StAR and Serum Corticosterone in VIP Receptor 2-Deficient Mice

Jan Fahrenkrug, Birgitte Georg, Jens Hannibal, Henrik Løvendahl Jørgensen

Journal of Molecular Neuroscience > 2012 > 48 > 3 > 584-596

The circadian time-keeping system consists of clocks in the suprachiasmatic nucleus (SCN) and in peripheral organs including an adrenal clock linked to the rhythmic corticosteroid production by regulating steroidogenic acute regulatory protein (StAR). Clock cells contain an autonomous molecular oscillator based on a group of clock genes and their protein products. Mice lacking the VPAC2 receptor display...

article

Localisation of the neuropeptide PACAP and its receptors in the rat parathyroid and thyroid glands

Jan Fahrenkrug, Jens Hannibal

General and Comparative Endocrinology > 2011 > 171 > 1 > 105-113

PACAP (pituitary adenylate cyclase activating polypeptide) is widely distributed neuropeptide acting via three subtypes of receptors, PAC ₁ , VPAC ₁ and VPAC ₂ . Here we examined the localisation and nature of PACAP-immunoreactive nerves in the rat thyroid and parathyroid glands and defined the distribution of PAC ₁ , VPAC ₁ and VPAC ₂ receptor mRNA’s...

article

Melanopsin-expressing retinal ganglion cells: implications for human diseases

Chiara La Morgia, Fred N. Ross-Cisneros, Jens Hannibal, Pasquale Montagna, more

Vision Research > 2011 > 51 > 2 > 296-302

In the last decade, there was the seminal discovery of melanopsin-expressing retinal ganglion cells (mRGCs) as a new class of photoreceptors that subserve the photoentrainment of circadian rhythms and other non-image forming functions of the eye. Since then, there has been a growing research interest on these cells, mainly focused on animal models. Only recently, a few studies have started to address...

article

Cholecystokinin (CCK)‐expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK‐deficient mice

Jens Hannibal, Christian Hundahl, Jan Fahrenkrug, Jens F. Rehfeld, more

European Journal of Neuroscience > 32 > 6 > 1006 - 1017

The suprachiasmatic nucleus (SCN) is the principal pacemaker driving circadian rhythms of physiology and behaviour. Neurons within the SCN express both classical and neuropeptide transmitters which regulate clock functions. Cholecyctokinin (CCK) is a potent neurotransmitter expressed in neurons of the mammalian SCN, but its role in circadian timing is not known. In the present study, CCK was demonstrated...

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INFONA - science communication portal

Search results for: Jens Hannibal

Larger interface area at the human myotendinous junction in type 1 compared with type 2 muscle fibers

Prevention of retinal ganglion cell death by GPR81 agonist treatment

Decreased glucose metabolism and glutamine synthesis in the retina of a transgenic mouse model of Alzheimer’s disease

Pituitary adenylate cyclase‐activating peptide: Potential roles in the pathophysiology and complications of cirrhosis

Spatiotemporal expression pattern of PERIOD 1 and PERIOD 2 in the mouse SCN is dependent on VIP receptor 2 signaling

Cover Image, Volume 526, Issue 12

Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas—A comparative study

Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always

Wavy multistratified amacrine cells in the monkey retina contain immunoreactive secretoneurin

Melanopsin expressing human retinal ganglion cells: Subtypes, distribution, and intraretinal connectivity

Melanopsin retinal ganglion cell loss in Alzheimer disease

The Light‐Induced FOS Response in Melanopsin Expressing HEK‐293 Cells is Correlated with Melanopsin Quantity and Dependent on Light Duration and Irradiance

Differential expression of melanopsin mRNA and protein in Brown Norwegian rats

Circadian rhythms and food anticipatory behavior in Wfs1-deficient mice

Altered pupillary light reflex in PACAP receptor 1-deficient mice

Altered Rhythm of Adrenal Clock Genes, StAR and Serum Corticosterone in VIP Receptor 2-Deficient Mice

Localisation of the neuropeptide PACAP and its receptors in the rat parathyroid and thyroid glands

Melanopsin-expressing retinal ganglion cells: implications for human diseases

Cholecystokinin (CCK)‐expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK‐deficient mice

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