Search results for: Hai‐Xia Fu

Items from 1 to 20 out of 27 results

article

Clinical features and prognostic model for viral encephalitis after allogeneic haematopoietic stem cell transplantation

Jin Wu, Yu‐Chen He, Qiu‐Sha Huang, Yun He, more

British Journal of Haematology > 205 > 4 > 1477 - 1488

The objective of this study was to identify independent prognostic factors of viral encephalitis (VE) after allogeneic haematopoietic stem cell transplantation (allo‐HSCT) and establish a prognostic model to identify post‐transplant VE patients with a greater likelihood of mortality. Among 5380 patients in our centre from 2014 to 2022, 211 patients who developed VE after allo‐HSCT were reviewed in...

article

Safety and efficacy of baricitinib in steroid‐resistant or relapsed immune thrombocytopenia: An open‐label pilot study

Peng Zhao, Zhuo‐Yu An, Hai‐Xia Fu, Hui‐Xin Liu, more

American Journal of Hematology > 99 > 10 > 1951 - 1958

Patients with steroid‐resistant or relapsed immune thrombocytopenia (ITP) suffer increased bleeding risk and impaired quality of life. Baricitinib, an oral Janus‐associated kinases (JAK) inhibitor, could alleviate both innate and adaptive immune disorders without inducing thrombocytopenia in several autoimmune diseases. Accordingly, an open‐label, single‐arm, phase 2 trial (NCT05446831) was initiated...

article

RETRACTED: A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation

Cheng‐Jie Feng, Peng Zhao, Hai‐Xia Fu, Chen‐Hua Yan, more

American Journal of Hematology > 99 > 4 > 633 - 641

Herpes zoster (HZ) refers to the rash appearing on dermatomes due to varicella zoster virus (VZV) reactivation. The incidence of HZ is significantly higher in allogeneic hematopoietic stem cell transplantation (allo‐HSCT) recipients than in non‐HSCT recipients. Although acyclovir prophylaxis is routinely administered to every allo‐HSCT recipient for 1 year after transplantation, some individuals eventually...

article

Tacrolimus prevents complement‐mediated Nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and pyroptosis of mesenchymal stem cells from immune thrombocytopenia

Xuan Cai, Jin Wu, Zhuo‐Yu An, Chen‐Cong Wang, more

British Journal of Haematology > 202 > 5 > 995 - 1010

The abnormal immunomodulatory functions of mesenchymal stem cells (MSCs) have been implicated in the development of immune thrombocytopenia (ITP). Recent studies have suggested important effects of complement on immune cell function. However, whether complement modulates bone marrow MSCs function in ITP is poorly defined. Tacrolimus has recently been applied to the treatment of autoimmune diseases...

article

Predicting short‐term and long‐term mortalities from sepsis in patients who receive allogeneic haematopoietic stem cell transplantation

Ye‐Jun Wu, Hui‐Xin Liu, Xiao‐Lu Zhu, Hai‐Xia Fu, more

British Journal of Haematology > 202 > 2 > 344 - 355

Patients who receive allogeneic haematopoietic stem cell transplantation (allo‐HSCT) may develop sepsis, which result in a highly intensive care unit admission rate and mortality. Therefore, short‐term and long‐term prognostic models for sepsis after allo‐HSCT are urgently needed. We enrolled patients receiving allo‐HSCT who developed sepsis after allo‐HSCT at Peking University People's Hospital between...

article

Recombinant human thrombopoietin increases platelet count in severe thrombocytopenic patients with hepatitis B‐related cirrhosis: Multicentre real‐world observational study

Ru Feng, Yi Liu, Xiao‐Lu Zhu, Wan‐Yi Zhai, more

Journal of Viral Hepatitis > 29 > 5 > 306 - 316

Patients with hepatitis B‐related cirrhosis complicated with thrombocytopenia have a higher risk of bleeding, which may lead to higher mortality. We aimed to explore the efficacy and safety of recombinant human thrombopoietin (rhTPO) in the treatment of hepatitis B‐related cirrhosis complicated with severe thrombocytopenia. Patients with hepatitis B‐related compensated liver cirrhosis complicated...

article

HCMV modulates c‐Mpl/IEX‐1 pathway‐mediated megakaryo/thrombopoiesis via PDGFRα and αvβ3 receptors after allo‐HSCT

Fei‐Er Feng, Gao‐Chao Zhang, Feng‐Qi Liu, Yun He, more

Journal of Cellular Physiology > 236 > 9 > 6726 - 6741

Thrombocytopenia is a common complication of human cytomegalovirus (HCMV) infection in immunocompromised hosts, which contributes to poor prognosis even in patients receiving antiviral treatment. Here, we investigated the megakaryo/thrombopoiesis process, including the involvement of the c‐Mpl/IEX‐1 pathway, after HCMV infection, identified receptors mediating the interaction between megakaryocytes...

article

IgG synthesis rate and anti-myelin oligodendrocyte glycoprotein antibody in CSF may be associated with the onset of CNS demyelination after haplo-HSCT

Xiao-hui Zhang, Xin Zhao, Chen-cong Wang, Wei Han, more

Annals of Hematology > 2018 > 97 > 8 > 1399-1406

Haploidentical hematopoietic stem cell transplant (haplo-HSCT) is an upfront and effective therapy for hematology patients, but it usually has many complications, such as neurological complications. As one of the neurological complications following haplo-HSCT, immune-mediated demyelinating diseases of the central nervous system (CNS) seriously affect a patient’s quality of life. However, the incidence,...

article

Mesenchymal stem cell deficiency influences megakaryocytopoiesis through the TNFAIP3/NF‐κB/SMAD pathway in patients with immune thrombocytopenia

Yun He, Lin‐Lin Xu, Fei‐Er Feng, Qian‐Ming Wang, more

British Journal of Haematology > 180 > 3 > 395 - 411

Immune thrombocytopenia (ITP) is an autoimmune disease. Mesenchymal stem cells (MSCs) play important roles in the physiology and homeostasis of the haematopoietic system, including supporting megakaryocytic differentiation from CD34⁺ haematopoietic progenitor cells. Tumour necrosis factor alpha‐induced protein 3 (TNFAIP3, also termed A20) plays a key role in terminating NF‐κB signalling. Human genetic...

article

Thrombotic microangiopathy with concomitant GI aGVHD after allogeneic hematopoietic stem cell transplantation: Risk factors and outcome

Xiao‐hui Zhang, Xiao Liu, Qian‐ming Wang, Yun He, more

European Journal of Haematology > 100 > 2 > 171 - 181

Objectives To explore the possible risk factors for the occurrence and mortality of thrombotic microangiopathy (TMA) with concomitant acute graft‐vs‐host disease (aGVHD) and to investigate outcomes and treatments of this disorder after allo‐HSCT. Methods Fifty cases diagnosed with TMA with concomitant aGVHD and 150 controls were identified from a cohort composed of 3992 patients who underwent allo‐HSCT...

article

Apical aneurysm, apical thrombus, ventricular tachycardia and cerebral hemorrhagic infarction in a patient of mid-ventricular non-obstructive hypertrophic cardiomyopathy: A case report

Ji-Fang Ma, Hai-Xia Fu

International Journal of Cardiology > 2016 > 220 > C > 828-832

article

High-dose corticosteroid associated with catheter-related thrombosis after allogeneic hematopoietic stem cell transplantation

Xiao-Hui Zhang, Fei-Er Feng, Wei Han, Feng-Rong Wang, more

Thrombosis Research > 2016 > 144 > C > 6-11

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients are at an increased risk of thrombotic complications, most of which are catheter-related and present a substantial challenge. The incidence of CRT varies considerably depending on clinical factors. However, the underlying pathogenesis and risk factors remain unclear.We performed a retrospective nested case-control study in patients...

article

Outcomes and Complications of Lead Removal: Can We Establish a Risk Stratification Schema for a Collaborative and Effective Approach?

HAI‐XIA FU, XIN‐MIAO HUANG, LI ZHONG, MICHAEL J. OSBORN, more

Pacing and Clinical Electrophysiology > 38 > 12 > 1439 - 1447

BackgroundRemoval of an entire cardiovascular implantable electronic device is associated with morbidity and mortality. We sought to establish a risk classification scheme according to the outcomes of transvenous lead removal in a single center, with the goal of using that scheme to guide electrophysiology lab versus operating room extraction. MethodsConsecutive patients undergoing transvenous lead...

article

Prophylactic use of low-dose interleukin-2 early post-transplantation: a randomised study

Xiangyu Zhao, Xiaosu Zhao, Yutong Wang, Ying-Jun Chang, more

The Lancet > 2015 > 386 > Supplement 1 > S7

Evidence suggests that natural killer cells and regulatory CD4⁺CD25⁺FoxP3⁺ T (T_reg) cells, which are expanded and stimulated by the application of interleukin-2, could mediate protection against graft-versus-host disease (GVHD) while maintaining graft anti-tumour activity. The aim of this study was to confirm that a low dose of interleukin-2 can prevent relapse while reducing chronic GVHD. This study...

article

Combination of FVIII and low-dose rFVIIa improves haemostasis in acquired haemophilia A patients: a collaborative controlled study

Xiao-hui Zhang, Xiao-lu Zhu, Ting Niu, Jing Sun, more

Thrombosis Research > 2015 > 135 > 5 > 835-840

Acquired haemophilia A (AHA) is an autoimmune disease that potentially leads to severe bleeding and has a high rate of mortality. This collaborative study aimed to assess the efficacy of the co-administration of FVIII and low-dose rFVIIa in patients with AHA.This study retrospectively compared the combined FVIII/low-dose rFVIIa therapy (initial dose range of 25–55μg/Kg) with the combined FVIII/PCC...

article

Recruitment of CD8⁺ T cells into bone marrow might explain the suppression of megakaryocyte apoptosis through high expression of CX3CR1⁺ in prolonged isolated thrombocytopenia after allogeneic hematopoietic stem cell transplantation

Xiao-Hui Zhang, Guo-Xiang Wang, Hong-Hu Zhu, Yan-Rong Liu, more

Annals of Hematology > 2015 > 94 > 10 > 1689-1698

Prolonged isolated thrombocytopenia is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is associated with a poor prognosis. This study aimed to investigate the pathogenesis of prolonged isolated thrombocytopenia (PT). We analysed the expression of CX3CR1 on CD4 and CD8 T cells in bone marrow (BM) and peripheral blood (PB) at +90 days from allo-HSCT...

article

Outcome and Management of Pacemaker‐Induced Superior Vena Cava Syndrome

HAI‐XIA FU, XIN‐MIAO HUANG, LI ZHONG, MICHAEL J. OSBORN, more

Pacing and Clinical Electrophysiology > 37 > 11 > 1470 - 1476

BackgroundWe aimed to determine the long‐term outcomes of percutaneous lead extraction and stent placement in patients with pacemaker‐induced superior vena cava (SVC) syndrome. MethodsThe study retrospectively screened patients who underwent lead extraction followed by central vein stent implantation at Mayo Clinic (Rochester, MN, USA), from January 2005 to December 2012, to identify the patients with pacemaker‐induced SVC syndrome. Demographic, clinical, and follow‐up characteristics of those patients were collected from electronic medical records...

article

Outcomes of Lead Revision for Myocardial Perforation After Cardiac Implantable Electronic Device Placement

XIN‐MIAO HUANG, HAI‐XIA FU, LI ZHONG, MICHAEL J. OSBORN, more

Journal of Cardiovascular Electrophysiology > 25 > 10 > 1119 - 1124

IntroductionCardiac perforation is an infrequent but potentially life‐threatening complication associated with placement of a cardiac implantable electronic device (CIED). The objective of this study was to determine the outcomes of percutaneous lead revision in patients who had lead perforation of the myocardium after CIED placement. Methods and ResultsWe reviewed records of 1,458 patients who underwent...

article

Cytomegalovirus is a potential risk factor for late‐onset hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation

Ting‐Ting Han, Lan‐Ping Xu, Dai‐Hong Liu, Kai‐Yan Liu, more

American Journal of Hematology > 89 > 1 > 55 - 61

Late‐onset hemorrhagic cystitis (LOHC) is a common complication following allogeneic hematopoietic stem cell transplantation (allo‐HSCT) and is primarily associated with viral infection. We prospectively quantified cytomegalovirus (CMV), BK virus (BKV), and adenovirus in urine and plasma using Q‐RT‐PCR in 50 consecutive patients to define the relationship between virus and LOHC. Of the 50 patients,...

article

Persistent luminescent nanoparticles for super-long time in vivo and in situ imaging with repeatable excitation

Meng Sun, Zhan-Jun Li, Chun-Lin Liu, Hai-Xia Fu, more

Journal of Luminescence > 2014 > 145 > Complete > 838-842

In order to realize super-long time (more than 3 days) in vivo imaging, SrAl ₂ O ₄ :Eu ²⁺ ,Dy ³⁺ (SAO) nanoparticles were employed as probes with in situ repeatable excitation capability. In our experiments, strontium aluminate nanoparticles were prepared. After surface modified with pyrophosphoric acid (PPA), grafted by PEG-5000-OCH ₃ and irradiated with 365nm...

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INFONA - science communication portal

Search results for: Hai‐Xia Fu

Clinical features and prognostic model for viral encephalitis after allogeneic haematopoietic stem cell transplantation

Safety and efficacy of baricitinib in steroid‐resistant or relapsed immune thrombocytopenia: An open‐label pilot study

RETRACTED: A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation

Tacrolimus prevents complement‐mediated Nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and pyroptosis of mesenchymal stem cells from immune thrombocytopenia

Predicting short‐term and long‐term mortalities from sepsis in patients who receive allogeneic haematopoietic stem cell transplantation

Recombinant human thrombopoietin increases platelet count in severe thrombocytopenic patients with hepatitis B‐related cirrhosis: Multicentre real‐world observational study

HCMV modulates c‐Mpl/IEX‐1 pathway‐mediated megakaryo/thrombopoiesis via PDGFRα and αvβ3 receptors after allo‐HSCT

IgG synthesis rate and anti-myelin oligodendrocyte glycoprotein antibody in CSF may be associated with the onset of CNS demyelination after haplo-HSCT

Mesenchymal stem cell deficiency influences megakaryocytopoiesis through the TNFAIP3/NF‐κB/SMAD pathway in patients with immune thrombocytopenia

Thrombotic microangiopathy with concomitant GI aGVHD after allogeneic hematopoietic stem cell transplantation: Risk factors and outcome

Apical aneurysm, apical thrombus, ventricular tachycardia and cerebral hemorrhagic infarction in a patient of mid-ventricular non-obstructive hypertrophic cardiomyopathy: A case report

High-dose corticosteroid associated with catheter-related thrombosis after allogeneic hematopoietic stem cell transplantation

Outcomes and Complications of Lead Removal: Can We Establish a Risk Stratification Schema for a Collaborative and Effective Approach?

Prophylactic use of low-dose interleukin-2 early post-transplantation: a randomised study

Combination of FVIII and low-dose rFVIIa improves haemostasis in acquired haemophilia A patients: a collaborative controlled study

Recruitment of CD8⁺ T cells into bone marrow might explain the suppression of megakaryocyte apoptosis through high expression of CX3CR1⁺ in prolonged isolated thrombocytopenia after allogeneic hematopoietic stem cell transplantation

Outcome and Management of Pacemaker‐Induced Superior Vena Cava Syndrome

Outcomes of Lead Revision for Myocardial Perforation After Cardiac Implantable Electronic Device Placement

Cytomegalovirus is a potential risk factor for late‐onset hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation

Persistent luminescent nanoparticles for super-long time in vivo and in situ imaging with repeatable excitation

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