Search results for: Kentaro Jingushi

Items from 1 to 11 out of 11 results

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Hypoxia regulates tumour characteristic RNA modifications in ovarian cancers

Yuya Monoe, Shunsuke Miyamoto, Kentaro Jingushi, Masaya Tanimoto, more

The FEBS Journal > 290 > 8 > 2085 - 2096

Analysis of ovarian cancer tissue and normal ovarian tissue revealed 31 RNA modifications with significant differences observed in cancer tissue compared with normal tissue. Moreover, we found Im and chm5U as characteristic RNA modifications in advanced and platinum‐resistant ovarian cancers, respectively. Considering that these differences in RNA modifications may be due to the intra‐tumour microenvironment,...

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Azurocidin is loaded into small extracellular vesicles via its N‐linked glycosylation and promotes intravasation of renal cell carcinoma cells

Takuya Naito, Kentaro Jingushi, Koji Ueda, Kazutake Tsujikawa

FEBS Letters > 595 > 19 > 2522 - 2532

Azurocidin (AZU1) is an antimicrobial protein secreted by neutrophils that acts as a chemoattractant for monocytes and macrophages and a permeabilizer of vascular endothelial cells. We previously identified AZU1 to be specifically present in extracellular vesicles (EVs) obtained from renal cell carcinoma (RCC) tissues. Here, we examined the relationship between N‐linked glycosylation and AZU1 loading...

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Extracellular vesicles isolated from human renal cell carcinoma tissues disrupt vascular endothelial cell morphology via azurocidin

Kentaro Jingushi, Motohide Uemura, Naomi Ohnishi, Wataru Nakata, more

International Journal of Cancer > 142 > 3 > 607 - 617

Cancer‐associated extracellular vesicles (EVs) are intimately involved in establishment of tumor microenvironment and occurrence of metastasis. However, previous studies have mainly relied on experiments with cultured cell lines or mouse models, making it difficult to gain a full understanding of EV functions in human body. Hence, we extracted EVs directly from surgically resected viable clear cell...

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Peripheral blood monocyte count reflecting tumor‐infiltrating macrophages is a predictive factor of adverse pathology in radical prostatectomy specimens

Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, more

The Prostate > 77 > 14 > 1383 - 1388

Background Tumor‐infiltrating macrophages, which are thought to be derived from blood monocytes, interact with tumor cells to promote cancer progression. The aim of this study was to assess the association of peripheral blood monocyte count with pathological findings and local tumor‐infiltrating macrophages in prostatectomy specimens. Methods Preoperative peripheral blood monocyte counts were retrospectively...

article

TP53 gene status is a critical determinant of phenotypes induced by ALKBH3 knockdown in non-small cell lung cancers

Takahiro Kogaki, Ikumi Ohshio, Megumi Kawaguchi, Mizuki Kimoto, more

Biochemical and Biophysical Research Communications > 2017 > 488 > 2 > 285-290

Human AlkB homolog 3 (ALKBH3) is overexpressed in non-small cell lung cancers (NSCLC) and its high expression is significantly correlated with poor prognosis. While ALKBH3 knockdown induces apoptosis in NSCLC cells, the underlying anti-apoptotic mechanisms of ALKBH3 in NSCLC cells remain unclear. Here we show that ALKBH3 knockdown induces cell cycle arrest or apoptosis depending on the TP53 gene status...

article

ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin

Ikumi Ohshio, Ryoji Kawakami, Yohei Tsukada, Kazuhiro Nakajima, more

Biochemical and Biophysical Research Communications > 2016 > 477 > 3 > 413-418

Human AlkB homolog 8 (ALKBH8) is highly expressed in high-grade, superficially and deeply invasive bladder cancer. Moreover, ALKBH8 knockdown induces apoptosis in bladder cancer cells. However, the underlying anti-apoptotic mechanism of ALKBH8 in bladder cancer cells has thus far remained unclear. Moreover, there is no direct evidence that highly expressed ALKBH8 is involved in tumor progression in vivo...

article

MP47-01 OVEREXPRESSED MIR-27A-3P IS AS INDEPENDENT PROGNOSTIC FACTOR FOR RECURRENCE IN CLEAR CELL RENAL CELL CARCINOMA

Wataru Nakata, Motohide Uemura, Toshiro Kinouchi, Takuji Hayashi, more

The Journal of Urology > 2015 > 193 > 4 Supplement > e552

article

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Fumi Takahashi-Yanaga, Tatsuya Yoshihara, Kentaro Jingushi, Kazuhiro Igawa, more

Biochemical Pharmacology > 2014 > 89 > 3 > 340-348

We reported that differentiation-inducing factor-1 (DIF-1), synthesized by Dictyostelium discoideum, inhibited proliferation of various tumor cell lines in vitro by suppressing the Wnt/β-catenin signaling pathway. However, it remained unexplored whether DIF-1 also inhibits tumor growth in vivo. In the present study, therefore, we examined in-vivo effects of DIF-1 using three cancer models: Mutyh-deficient...

article

DIF-1 inhibits the Wnt/β-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines

Kentaro Jingushi, Fumi Takahashi-Yanaga, Tatsuya Yoshihara, Fumie Shiraishi, more

Biochemical Pharmacology > 2012 > 83 > 1 > 47-56

We previously reported that differentiation-inducing factor-1 (DIF-1), a morphogen in Dictyostelium discoideum, inhibits the proliferation of human cancer cell lines by inducing β-catenin degradation and suppressing the Wnt/β-catenin signaling pathway. To determine whether β-catenin degradation is essential for the effect of DIF-1, we examined the effect of DIF-1 on human colon cancer cell lines (HCT-116,...

article

Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells

Fumi Takahashi-Yanaga, Tatsuya Yoshihara, Kentaro Jingushi, Yoshikazu Miwa, more

Biochemical and Biophysical Research Communications > 2008 > 377 > 4 > 1185-1190

We examined the effect of celecoxib on the expression of T-cell factors (TCFs) to clarify the mechanism by which celecoxib suppress β-catenin/TCF-dependent transcriptional activity without reducing the level of β-catenin protein, using HCT-116 cells. Celecoxib suppressed the expression of TCF-1 and TCF-4 in a time-dependent manner. Pretreatment of cells with the proteasome inhibitor MG132 inhibited...

article

In vivo banking for vascularized autograft bone by intramuscular inoculation of recombinant human bone morphogenetic protein-2 and β-tricalcium phosphate

Wei-Jia Chen, Seiya Jingushi, Kentaro Jingushi, Yukihide Iwamoto

Journal of Orthopaedic Science > 2006 > 11 > 3 > 283-288

Background The gold standard of bone graft substitutes is vascularized autologous bone. Our strategy to acquire this bone substitute is using recombinant human bone morphogenetic protein (rhBMP)-2 with β-tricalcium phosphate (TCP) as carrier to induce bone tissue in muscle and grafting as a muscle-pedicled bone flap. In our previous studies, morphologically controlled living bone was successfully...

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