Search results for: Matin Mahmoudifard

Items from 1 to 15 out of 15 results

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Novel simulation of the blood–brain barrier using the polyacrylonitrile electrospun nanofibrous membrane on 3D‐printed Transwell

Mohammad Raeiji, Dina Morshedi, Matin Mahmoudifard

Polymers for Advanced Technologies > 35 > 4 > n/a - n/a

The blood–brain barrier (BBB) possesses an intricate structure and set of characteristics that effectively restricts the transportation of substances to the central nervous system. Consequently, the development of pharmaceuticals for brain disorders poses significant hurdles. Numerous attempts have been made to produce innovative simulates of BBB that exhibit a striking resemblance to BBB and are...

article

Study on the antibacterial effect of CuO nanoparticles on Klebsiella pneumonia bacteria: Efficient treatment for colorectal cancer

Maria Valadbeigi, Matin Mahmoudifard, Shahla Mohammad Ganji, Sedigheh Mehrabian

Biotechnology and Applied Biochemistry > 70 > 6 > 1785 - 1793

Colorectal cancer (CRC) is a widespread type of cancer across the world. One efficient therapy approach is the use of antibiotic agents, but one of the main issues related to treating CRC is microbial resistance to antibiotics. As microbes are becoming more resistant to antibiotics and other traditional antimicrobial agents, nanobiotechnology has made it possible to employ nanomaterials with the aim...

article

Microfluidic Synthesis of Ultrasmall Chitosan/Graphene Quantum Dots Particles for Intranasal Delivery in Alzheimer's Disease Treatment

Fariba Mohebichamkhorami, Mehrdad Faizi, Matin Mahmoudifard, Arman Hajikarim‐Hamedani, more

Small > 19 > 40 > n/a - n/a

Nanoparticles (NPs) based therapies for Alzheimer's disease (AD) attract interest due to their ability to pass across or bypass the blood‐brain barrier. Chitosan (CS) NPs or graphene quantum dots (GQDs) are promising drug carriers with excellent physicochemical and electrical properties. The current study proposes the combination of CS and GQDs in ultrasmall NP form not as drug carriers but as theranostic...

article

The detection of the captured circulating tumor cells on the core‐shell nanofibrous membrane using hyaluronic acid‐functionalized graphene quantum dots

Sahar Asghari, Matin Mahmoudifard

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 111 > 5 > 1121 - 1132

In recent years, cancerous cases have increased remarkably worldwide, and metastasis is the leading cause of death. Therefore, research on the early detection of cancer and metastasis has expanded to aid successful cancer treatment. Here in this paper, at the first step, an electrospun nanofibrous membrane (NFM) with a core‐shell structure was fabricated from PCL and HA to achieve cancer cell capturing...

article

Hyaluronic acid–graphene quantum dot nanocomposite: Potential target drug delivery and cancer cell imaging

Nasrin Vahedi, Fatemeh Tabandeh, Matin Mahmoudifard

Biotechnology and Applied Biochemistry > 69 > 3 > 1068 - 1079

Nowadays, the use of nanoparticle‐based drug delivery systems has received much more attention. In this regard, here, graphene quantum dots (GQD) were used as drug carriers as well as imaging agents for cancer cells. In order to optimize the dose of the drug and reduce its side effects for healthy cells, hyaluronic acid was decorated on the surface of GQD to target cancer cells. The morphology and...

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Core‐shell nanofibrous membrane of polycaprolactone‐hyaluronic acid as a promising platform for the efficient capture and release of circulating tumor cells

Sahar Asghari, Matin Mahmoudifard

Polymers for Advanced Technologies > 32 > 3 > 1101 - 1113

According to the increase of deaths due to the metastasis of primary tumors in many cancers, a smart system is required to recognize the initialization of metastasis, immediately and efficiently. In this paper, we introduce a novel platform based on the electrospun nanofibrous membranes (NFMs) for efficient capture of circulating tumor cells (CTCs) and then release them for further study. It is important...

article

Different PES nanofibrous membrane parameters effect on the efficacy of immunoassay performance

Matin Mahmoudifard, Manuchehr Vossoughi

Polymers for Advanced Technologies > 30 > 8 > 1968 - 1977

The contribution of electrospun nanofibrous membranes (e.NFMs) in the biosensing platforms opens up a new prospect for the invention of faster and more sensitive analytical devices. In this paper, we utilized e.NFM of polyethersulfone (PES) as a solid substrate for the protein immobilization through two different approaches: physical and covalent. Scanning electron microscopy (SEM) and Fourier‐transform‐infrared...

article

Different types of electrospun nanofibers and their effect on microfluidic‐based immunoassay

Matin Mahmoudifard, Manouchehr Vossoughi, Masoud Soleimani

Polymers for Advanced Technologies > 30 > 4 > 973 - 982

Protein capturing on polymeric substrate of microfluidic devices is a key factor for the fabrication of immunoassay with high sensitivity. In this work, simple and versatile technique of electrospinning was used to produce electrospun nanofibrous membranes (e.NFMs) with high surface area as a substrate for microfluidic‐based immunoassay to increase sensitivity. It was found that the simultaneous use...

article

Electrospun polyethersolfone nanofibrous membrane as novel platform for protein immobilization in microfluidic systems

Matin Mahmoudifard, Manouchehr Vossoughi, Sara Soudi, Masoud Soleimani

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 106 > 3 > 1108 - 1120

In the present study, the feasibility of electrospun polyethersolfone (PES) nanofibrous membrane as the solid substrate for microfluidic based immunoassays to enhance the density of immobilized antibody on the surface of membrane was assessed. Conversely, the efficacy of antibody immobilization was compared by two different strategies as 1‐Ethyl‐3‐(3‐dimethylaminopropyl)‐carbodiimide (EDC)/N‐Hydroxysuccinimide...

article

Study of epithelial differentiation and protein expression of keratinocyte-mesenchyme stem cell co-cultivation on electrospun nylon/B. vulgaris extract composite scaffold

Simzar Hosseinzadeh, Masoud Soleimani, Manuchehr Vossoughi, Parviz Ranjbarvan, more

Materials Science and Engineering: C > 2017 > 75 > C > 653-662

Employing of the composite electrospun scaffold containing herbal extract in conjugation with co-culturing of cells can open up new window to the design of efficient biomaterials for skin tissue regeneration. Here, we introduce the synergistic effect of composite electrospun nanofibrous scaffold of nylon66 loaded with Beta vulgaris (B. vulgaris) (extract of beet roots, a plants whose widely used in...

article

Nanofibrous hydrogel with stable electrical conductivity for biological applications

Simzar Hosseinzadeh, Sayed Mahdi Rezayat, Ebrahim Vashegani-Farahani, Matin Mahmoudifard, more

Polymer > 2016 > 97 > C > 205-216

3D hydrogel environment with both unique properties of nanofibrous structure and electrical character can provide a promising scaffold for skeletal muscle tissue engineering approaches. Herein, the poly acrylic acid (PAA)-based hydrogel was engineered to conductive one by aniline polymerization in the form of nanofibers. The poly aniline (PANi) nanofibers were made by the optimized chemical reactions...

article

The nanofibrous PAN-PANi scaffold as an efficient substrate for skeletal muscle differentiation using satellite cells

Simzar Hosseinzadeh, Matin Mahmoudifard, Farzaneh Mohamadyar-Toupkanlou, Masomeh Dodel, more

Bioprocess and Biosystems Engineering > 2016 > 39 > 7 > 1163-1172

Among polymers, polyaniline (PANi) has been introduced as a good candidate for muscle regeneration due to high conductivity and also biocompatibility. Herein, for the first time, we report the use of electrospun nanofibrous membrane of PAN-PANi as efficient scaffold for muscle regeneration. The prepared PAN-PANi electrospun nanofibrous membrane was characterized by scanning electron microscopy (SEM),...

article

Efficient protein immobilization on polyethersolfone electrospun nanofibrous membrane via covalent binding for biosensing applications

Matin Mahmoudifard, Sara Soudi, Masoud Soleimani, Simzar Hosseinzadeh, more

Materials Science and Engineering: C > 2016 > 58 > C > 586-594

In this paper we introduce novel strategy for antibody immobilization using high surface area electrospun nanofibrous membrane based on ethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling chemistry. To present the high performance of proposed biosensors, anti-staphylococcus enterotoxin B (anti-SEB) was used as a model to demonstrate the utility of our proposed system...

article

Quantum dot/polyvinyl alcohol composite nanofibers membrane as highly sensitive fluorescence quenching-based sensors

Matin Mahmoudifard, Ahmad Mousavi Shoushtari, Maryam Shanehsaz

Fibers and Polymers > 2014 > 15 > 9 > 1797-1803

Nanofibrous membranes are intensively applied to fabricate advanced intelligent devices like highly sensitive sensors due to their flexibility, high porosity, high surface area and good mechanical and chemical stability. In this work, fluorescent cadmium telluride (CdTe) quantum dots (Q.Ds) were synthesized and then uniformly embedded in poly vinyl alcohol (PVA) nanofibers by electrospinning technique...

article

Fabrication and characterization study of electrospun quantum dot — poly vinyl alcohol composite nanofiber for novel engineering applications

Matin Mahmoudifard, Ahmad Mousavi Shoushtari, Afshin Mohsenifar

Fibers and Polymers > 2012 > 13 > 8 > 1031-1036

CdTe quantum dot/PVA (poly vinyl alcohol) composite nanofiber was successfully fabricated by eletrospinning process. CdTe quantum dots were uniformly dispersed and stabilized into solid nanofiber structure. Spectrofluorometer analysis revealed whenever Q.D’s enter to the PVA solution, due to the aggregation of Q.D’s red shift happens; however, when blend Q.D-PVA solution changes to nanofiber form...

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