Search results for: Vittorio Sirolli

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Erythropoietin induces miRNA‐210 by JAK2/STAT5 signaling in PBMCs of End‐stage Renal Disease patients

Paolo Felaco, Mario Felaco, Sara Franceschelli, Alessio Ferrone, more

The FEBS Journal > 287 > 23 > 5167 - 5182

Anemia of chronic kidney disease is associated with blunted response/resistance to erythropoietin‐stimulating agents (ESAs) in hemodialysis (HD) patients. Several molecules have been successfully associated with ESA responsiveness; however, none of them is now considered a valid therapeutic biomarker of erythropoietin resistance in these patients. We performed an evaluation of the level of specific...

article

Intensity, Duration, and Frequency of Post‐Dialysis Fatigue in Patients on Chronic Haemodialysis

Maurizio Bossola, Enrico Di Stasio, Tania Monteburini, Emanuele Parodi, more

Journal of Renal Care > 46 > 2 > 115 - 123

Background Although frequent and debilitating, little is known about the characteristics of post‐dialysis fatigue (PDF). Objective To characterise the intensity, duration and frequency of PDF and the associated variables in patients on chronic haemodialyses. Design Prospective, observational and multicenter study. Patients We studied 271 patients. Measurements Patients were considered to...

article

Prevalence and Severity of Postdialysis Fatigue Are Higher in Patients on Chronic Hemodialysis With Functional Disability

Maurizio Bossola, Enrico Di Stasio, Vittorio Sirolli, Fabio Ippoliti, more

Therapeutic Apheresis and Dialysis > 22 > 6 > 635 - 640

The aim of the present study was to determine the intensity, duration, frequency and prevalence of postdialysis fatigue (PDF) in patients on chronic hemodialysis (PCD) with and without functional disability. Patients underwent assessment of functional ability by the Katz ADL (activity daily living) questionnaire and the Lawton and Brody scale for the instrumental activity daily living (IADL) fatigue...

article

Proteomic Characterization of a New asymmetric Cellulose Triacetate Membrane for Hemodialysis

Maurizio Ronci, Lidia Leporini, Paolo Felaco, Vittorio Sirolli, more

PROTEOMICS – Clinical Applications > 12 > 6 > n/a - n/a

Purpose The artificial membrane inside the haemodialyzer is the main determinant of the quality and success of haemodialysis therapy. The performances of haemodialysis membranes are highly influenced by the interactions with plasma proteins, which in turn are related to the physical and chemical characteristics of the membrane material. The present cross‐over study is aimed to analyse the haemodialysis...

article

Prevalence and associated variables of post‐dialysis fatigue: Results of a prospective multicentre study

Maurizio Bossola, Emanuele Marzetti, Enrico Di Stasio, Tania Monteburini, more

Nephrology > 23 > 6 > 552 - 558

Aim The study aims to determine prevalence and severity of PDF and to define its associated variables. Methods In five haemodialysis units of northern‐centre Italy, patients were regarded to suffer from PDF if they spontaneously offered this complaint when asked the open‐ended question: Do you feel better or worse after dialysis? If worse, please specify in which way. A complaint of fatigue would...

article

New Treatment Approaches for the Anemia of CKD

Mario Bonomini, Lucia Del Vecchio, Vittorio Sirolli, Francesco Locatelli

American Journal of Kidney Diseases > 2016 > 67 > 1 > 133-142

Normocytic normochromic anemia is a common complication in chronic kidney disease and is associated with many adverse clinical consequences. Erythropoiesis-stimulating agents (ESAs) and adjuvant iron therapy represent the primary treatment for anemia in chronic kidney disease. The introduction of ESAs into clinical practice was a success story, mediating an increase in hemoglobin concentrations without...

article

Nitric oxide synthetic pathway and cGMP levels are altered in red blood cells from end-stage renal disease patients

Natalia Di Pietro, Annalisa Giardinelli, Vittorio Sirolli, Chiara Riganti, more

Molecular and Cellular Biochemistry > 2016 > 417 > 1-2 > 155-167

Red blood cells (RBCs) enzymatically produce nitric oxide (NO) by a functional RBC-nitric oxide synthase (RBC-NOS). NO is a vascular key regulatory molecule. In RBCs its generation is complex and influenced by several factors, including insulin, acetylcholine, and calcium. NO availability is reduced in end-stage renal disease (ESRD) and associated with endothelial dysfunction. We previously demonstrated...

article

Serum Fetuin A in Hemodialysis: A Link Between Derangement of Calcium-Phosphorus Homeostasis and Progression of Atherosclerosis?

Giovanni Pertosa, Simona Simone, Marco Ciccone, Silvia Porreca, more

American Journal of Kidney Diseases > 2009 > 53 > 3 > 467-474

Fetuin A, a circulating inhibitor of ectopic calcification, is downregulated in hemodialysis and has been shown to predict cardiovascular mortality in this setting. The association of altered calcium-phosphorus with serum fetuin A levels is still a matter of debate. Although carotid intima-media thickness (cIMT) is a strong predictor of major cardiovascular events, its association with serum fetuin...

article

Proteomics Characterization of Protein Adsorption onto Hemodialysis Membranes

Mario Bonomini, Barbara Pavone, Vittorio Sirolli, Francesca Del Buono, more

Journal of Proteome Research > 2006 > 5 > 10 > 2666 - 2674

article

Involvement of phosphatidylserine exposure in the recognition and phagocytosis of uremic erythrocytes

Mario Bonomini, Vittorio Sirolli, Marcella Reale, Arduino Arduini

American Journal of Kidney Diseases > 2001 > 37 > 4 > 807-814

Cell surface-exposed phosphatidylserine (PS) represents a signal for macrophage recognition and cell phagocytosis. This study examines PS exposure and susceptibility to erythrocyte phagocytosis in patients with chronic uremia in an attempt to assess the possible pathogenic mechanism behind cell removal in a condition associated with shortened erythrocyte life. Both PS-expressing erythrocytes and erythrophagocytosis...

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Keywords

FATIGUE (3)
HEMODIALYSIS (3)
ACTIVITY DAILY LIVING (2)
END-STAGE RENAL DISEASE (2)
POST‐DIALYSIS (2)
ACTIVIN TRAP (1)
ADSORPTION (1)
ANEMIA (1)
CALCIUM-PHOSPHORUS (1)
CELLULOSE TRIACETATE MEMBRANE (1)
CGMP (1)
CHRONIC KIDNEY DISEASE (CKD) (1)
CHRONIC RENAL INSUFFICIENCY (1)
DIALYSIS (1)
EPO RECEPTOR (1)
ERYTHROPOIESIS (1)
ERYTHROPOIESIS STIMULATING AGENT (ESA) (1)
ERYTHROPOIETIN (1)
ERYTHROPOIETIN (EPO) (1)
FETUIN A (1)
GENE THERAPY (1)
HAEMODIALYSES (1)
HAEMODIALYSIS (1)
HIF STABILIZER (1)
HYPOXIA-INDUCIBLE FACTOR (HIF) (1)
INSTRUMENTAL ACTIVITY DAILY LIVING (1)
INTIMA-MEDIA THICKNESS (1)
JAK2 (1)
LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (1)
MIRNA‐210 (1)
NITRIC OXIDE (1)
NITRIC OXIDE SYNTHASE (1)
PBMCS (1)
POST‐DIALYSIS FATIGUE (1)
PROLYL HYDROXYLASE INHIBITOR (1)
PROTEIN IDENTIFICATION (1)
RECOVERY TIME (1)
RED BLOOD CELLS (1)
RENAL ANEMIA (1)
REVIEW (1)
STAT5 (1)
ULTRAFILTRATION RATE (1)
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Wiley (5)
Elsevier (3)
ACS (1)
Springer (1)

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Search results for: Vittorio Sirolli

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