Search results for: Mitchell J Schwaber

Items from 1 to 11 out of 11 results

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Trends in antimicrobial resistance in Israel, 2014–2017

Yaakov Dickstein, Elizabeth Temkin, Michal Ish Shalom, David Schwartz, more

Antimicrobial Resistance & Infection Control > 2019 > 8 > 1 > 1-5

We analyzed Israeli national data on antimicrobial susceptibility from bloodstream isolates collected between 2014 and 2017 and compared resistance proportions with those of Europe. The incidence of bloodstream infection (BSI) caused by most antibiotic-resistant organisms remained unchanged or decreased. An exception was increased incidence of BSI caused by third-generation cephalosporin-resistant...

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Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study

Belén Gutiérrez-Gutiérrez, Elena Salamanca, Marina de Cueto, Po-Ren Hsueh, more

The Lancet Infectious Diseases > 2017 > 17 > 7 > 726-734

The best available treatment against carbapenemase-producing Enterobacteriaceae (CPE) is unknown. The objective of this study was to investigate the effect of appropriate therapy and of appropriate combination therapy on mortality of patients with bloodstream infections (BSIs) due to CPE. In this retrospective cohort study, we included patients with clinically significant monomicrobial BSIs due...

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A Predictive Model of Mortality in Patients With Bloodstream Infections due to Carbapenemase-Producing Enterobacteriaceae

Belén Gutiérrez-Gutiérrez, Elena Salamanca, Marina de Cueto, Po-Ren Hsueh, more

Mayo Clinic Proceedings > 2016 > 91 > 10 > 1362-1371

To develop a score to predict mortality in patients with bloodstream infections (BSIs) due to carbapenemase-producing Enterobacteriaceae (CPE).A multinational retrospective cohort study (INCREMENT project) was performed from January 1, 2004, through December 31, 2013. Patients with clinically relevant monomicrobial BSIs due to CPE were included and randomly assigned to either a derivation cohort (DC)...

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Prevalence and risk factors for carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among patients prior to bowel surgery

Iris Pfeffer, Meir Zemel, Yehuda Kariv, Hagit Mishali, more

Diagnostic Microbiology and Infectious Disease > 2016 > 85 > 3 > 377-380

Prophylactic antibiotics are an important measure in preventing perioperative infection, Failure to cover multidrug-resistant pathogens may place carriers at increased risk of infection. We conducted a prospective, cross-sectional study in patients prior to bowel surgery to measure the carriage prevalence of extended-spectrum β-lactamase-producing Enterobacteriaceae and identify risk factors for carriage...

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Pro-Arrhythmic Effects of Noncardiac Medications

Sami Viskin, Ofer Havakuk, Mitchell J. Schwaber

Journal of the American College of Cardiology > 2015 > 66 > 20 > 2185-2188

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A national survey of the molecular epidemiology of Clostridium difficile in Israel: the dissemination of the ribotype 027 strain with reduced susceptibility to vancomycin and metronidazole

Amos Adler, Tamar Miller-Roll, Rita Bradenstein, Colin Block, more

Diagnostic Microbiology & Infectious Disease > 2015 > 83 > 1 > 21-24

Our goals were to study the molecular epidemiology and antimicrobial susceptibilities of C. difficile strains in Israel. Microbiology laboratories serving 6 general hospitals (GH) and 10 long-term care facilities (LTCF) were asked to submit all stool samples in January–February 2014 that tested positive for C. difficile. Toxigenic C. difficile isolates were recovered in 208 out of 217 samples (95...

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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases

L Silvia Munoz-Price, Laurent Poirel, Robert A Bonomo, Mitchell J Schwaber, more

The Lancet Infectious Diseases > 2013 > 13 > 9 > 785-796

Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria, especially K pneumoniae, although their precise epidemiology is diverse across countries and regions. The mortality described among patients infected with organisms positive for KPC is high, perhaps as a result...

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Clonal transmission of a rare methicillin-resistant Staphylococcus aureus genotype between horses and staff at a veterinary teaching hospital

Mitchell J. Schwaber, Shiri Navon-Venezia, Samira Masarwa, Sharon Tirosh-Levy, more

Veterinary Microbiology > 2013 > 162 > 2-4 > 907-911

Methicillin-resistant Staphylococcus aureus (MRSA) infection or colonization has become a serious emerging condition in equine hospitals. Following the detection of MRSA in asymptomatic hospitalized horses and in two horses with post-operative wound infections, an investigation was conducted. Twelve of 84 horses (14.3%) and 16 of 139 personnel (11.5%) were MRSA carriers. The profile of the dominant...

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Pseudomonas aeruginosa bacteremia upon hospital admission: risk factors for mortality and influence of inadequate empirical antimicrobial therapy

Vered Schechner, Tamar Gottesman, Orna Schwartz, Maya Korem, more

Diagnostic Microbiology & Infectious Disease > 2011 > 71 > 1 > 38-45

Pseudomonas aeruginosa is an uncommon cause of bacteremia upon hospital admission (UHA) and the chosen empirical antimicrobial therapy may not cover it appropriately. In a multicenter prospective study conducted in Israel, we evaluated risk factors for in-hospital mortality in patients with P. aeruginosa bacteremia UHA and determined the influence of delay in adequate empirical antimicrobial therapy...

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The effects of group 1 versus group 2 carbapenems on imipenem-resistant Pseudomonas aeruginosa: an ecological study

Yehuda Carmeli, Shiri Klarfeld Lidji, Esther Shabtai, Shiri Navon-Venezia, more

Diagnostic Microbiology & Infectious Disease > 2011 > 70 > 3 > 367-372

Use of the group 2 carbapenems, imipenem and meropenem, may lead to emergence of Pseudomonas aeruginosa resistance. The group 1 carbapenem ertapenem has limited activity against P. aeruginosa and is not associated with imipenem-resistant P. aeruginosa (IMP-R PA) in vitro. This retrospective, group-level, longitudinal study collected patient, antibiotic use, and resistance data from 2001 to 2005 using...