Search results for: Kathleen J. Propert

Items from 1 to 20 out of 28 results

article

The Effect of Skin Pigmentation on the Accuracy of Pulse Oximetry in Infants with Hypoxemia

Elizabeth E. Foglia, Robin K. Whyte, Aasma Chaudhary, Antonio Mott, more

The Journal of Pediatrics > 2017 > 182 > C > 375-377.e2

To compare pulse oximetry measurement bias between infants with hypoxemia with either dark skin or light skin with Masimo Radical 7 and Nellcor Oximax. There was no significant difference in systematic bias based on skin pigment for either oximeter.

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Association Between Depression and Condom Use Differs by Sexual Behavior Group in Patients with HIV

Cristina Brickman, Kathleen J. Propert, Chelsea Voytek, David Metzger, more

AIDS and Behavior > 2017 > 21 > 6 > 1676-1683

Identifying a relationship between depression and sexual risk behavior in HIV-infected patients could establish a mechanism to enhance prevention efforts. We conducted a cross-sectional analysis using data from the University of Pennsylvania Center for AIDS Research and used ordinal logistic regression to measure the association between depression and non-condom use. 716 men who have sex with men...

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Is self‐reported adherence associated with clinical outcomes in women treated with anticholinergic medication for overactive bladder?

Uduak U. Andy, Lily A. Arya, Ariana L. Smith, Kathleen J. Propert, more

Neurourology and Urodynamics > 35 > 6 > 738 - 742

AimTo determine the association between self‐reported adherence to anticholinergic medication and clinical outcomes in women with overactive bladder (OAB). MethodsA prospective study of women with OAB treated with fesoterodine for 8 weeks. Adherence to medication was measured using the Medication Adherence Self‐report Inventory (MASRI). A self reported adherence rate of ≥80% was considered adherent...

article

Urinary incontinence and disability in community‐dwelling women: A cross‐sectional study

Joy A. Greer, Rengyi Xu, Kathleen J. Propert, Lily A. Arya

Neurourology and Urodynamics > 34 > 6 > 539 - 543

AimsDisability, an individual's reduced capacity to perform physical tasks encountered in daily routine, is associated with urinary incontinence in the elderly. Our objective was to determine if urinary incontinence is associated with disability in community‐dwelling women 40 years and older. MethodsCross‐sectional study among US women ≥40 years (n = 4,458) from National Health and Nutrition Examination...

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Validation of a self‐administered instrument to measure adherence to anticholinergic drugs in women with overactive bladder

Uduak U. Andy, Heidi S. Harvie, Ariana L. Smith, Kathleen J. Propert, more

Neurourology and Urodynamics > 34 > 5 > 424 - 428

AimTo validate a self‐administered instrument, the Medication Adherence Self‐Report Inventory (MASRI) for measuring adherence to anti‐cholinergic medication for overactive bladder (OAB). MethodsProspective study in 131 women with OAB treated with fesoterodine. Adherence was measured at 8 and 12 weeks using an interviewer administered brief medication questionnaire (BMQ) that assesses barriers to...

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Estimating the efficacy of an interstitial cystitis/painful bladder syndrome medication in a randomized trial with both non‐adherence and loss to follow‐up

Wei Yang, Kathleen J. Propert, J. Richard Landis

Statistics in Medicine > 33 > 20 > 3547 - 3555

We are motivated by a randomized clinical trial evaluating the efficacy of amitriptyline for the treatment of interstitial cystitis and painful bladder syndrome in treatment‐naïve patients. In the trial, both the non‐adherence rate and the rate of loss to follow‐up are fairly high. To estimate the effect of the treatment received on the outcome, we use the generalized structural mean model (GSMM),...

article

Omega‐3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers

Jane F. Ferguson, Claire K. Mulvey, Parth N. Patel, Rhia Y. Shah, more

Molecular Nutrition & Food Research > 58 > 3 > 601 - 613

ScopeFish oil‐derived n‐3 PUFA may improve cardiometabolic health through modulation of innate immunity. However, findings in clinical studies are conflicting. We hypothesized that n‐3 PUFA supplementation would dose‐dependently reduce the systemic inflammatory response to experimental endotoxemia in healthy humans. Methods and resultsThe Fenofibrate and omega‐3 Fatty Acid Modulation of Endotoxemia...

article

Construct validity of an instrument to measure neuropathic pain in women with bladder pain syndrome

Lily A. Arya, Heidi S. Harvie, Uduak U. Andy, Lori Cory, more

Neurourology and Urodynamics > 32 > 5 > 424 - 427

AimsTo determine the construct validity of an instrument to measure neuropathic pain in women with bladder pain syndrome (BPS). Our hypothesis is that neuropathic, bladder, and bowel pain represent different constructs in women with BPS. MethodsSecondary planned analysis of a prospective cross‐sectional study of 150 women with BPS. The relationship between neuropathic pain, urinary, and bowel symptoms...

article

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

Marina Cuchel, Emma A Meagher, Hendrik du Toit Theron, Dirk J Blom, more

The Lancet > 2013 > 381 > 9860 > 40-46

Patients with homozygous familial hypercholesterolaemia respond inadequately to existing drugs. We aimed to assess the efficacy and safety of the microsomal triglyceride transfer protein inhibitor lomitapide in adults with this disease. We did a single-arm, open-label, phase 3 study of lomitapide for treatment of patients with homozygous familial hypercholesterolemia. Current lipid lowering therapy...

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Early Termination of a Trial of Mycophenolate Mofetil for Treatment of Interstitial Cystitis/Painful Bladder Syndrome: Lessons Learned

Claire C. Yang, David A. Burks, Kathleen J. Propert, Robert D. Mayer, more

The Journal of Urology > 2011 > 185 > 3 > 901-906

We evaluated the efficacy and tolerability of mycophenolate mofetil in patients with treatment refractory interstitial cystitis/painful bladder syndrome. A total of 210 patients with interstitial cystitis/painful bladder syndrome were to be randomized into a multicenter, placebo controlled trial using a 2:1 randomization. Participants in whom at least 3 interstitial cystitis/painful bladder syndrome...

article

Analysis of B cell subsets following pancreatic islet cell transplantation in a patient with type 1 diabetes by cytometric fingerprinting

Debora R. Sekiguchi, Jennifer A. Sutter, Michael R. Rickels, Ali Naji, more

Journal of Immunological Methods > 2011 > 363 > 2 > 233-244

Manual gating of bivariate plots remains the most frequently used data analysis method in flow cytometry. However, gating is operator-dependent and cumbersome, particularly with the increasing complexity of modern multicolor immunophenotyping data. A method that can remove operator bias, enable systematic and thorough analysis of complex high-dimensional data, correlate temporal changes in different...

article

Effect of Amitriptyline on Symptoms in Treatment Naïve Patients With Interstitial Cystitis/Painful Bladder Syndrome

Harris E. Foster, Philip M. Hanno, J. Curtis Nickel, Christopher K. Payne, more

The Journal of Urology > 2010 > 183 > 5 > 1853-1858

Amitriptyline is frequently used to treat patients with interstitial cystitis/painful bladder syndrome. The evidence to support this practice is derived mainly from a small, single site clinical trial and case reports.We conducted a multicenter, randomized, double-blind, placebo controlled clinical trial of amitriptyline in subjects with interstitial cystitis/painful bladder syndrome who were naïve...

article

800 CATASTROPHIZING AND SPOUSAL RESPONSES IN MEN SUFFERING FROM CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME (CP/CPPS)

Dean A. Tripp, Jessica Ginting, J. Curtis Nickel, Kathleen J. Propert, more

The Journal of Urology > 2010 > 183 > 4 Supplement > e312-e313

article

Muscle Tenderness in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: The Chronic Prostatitis Cohort Study

Daniel A. Shoskes, Richard Berger, Angelo Elmi, J. Richard Landis, more

The Journal of Urology > 2008 > 179 > 2 > 556-560

Myofascial pain is a possible etiology for category III chronic prostatitis/chronic pelvic pain syndrome, either secondary to infection/inflammation or as the primary cause. We documented tenderness on physical examination in a large multicenter cohort of patients with chronic pelvic pain syndrome and compared to controls.Data were reviewed from the National Institutes of Health Chronic Prostatitis...

article

Sexual Function is a Determinant of Poor Quality of Life for Women With Treatment Refractory Interstitial Cystitis

J. Curtis Nickel, Dean Tripp, Valerie Teal, Kathleen J. Propert, more

The Journal of Urology > 2007 > 177 > 5 > 1832-1836

Interstitial cystitis significantly negatively impacts quality of life. The demographic and clinical factors associated with decreased quality of life in these patients have not been well studied.Women with moderate/severe interstitial cystitis enrolled in a clinical trial of intravesical bacillus Calmette-Guerin were studied. Demographic data and responses to questionnaires were evaluated at baseline,...

article

Discovery of Morphological Subgroups That Correlate With Severity of Symptoms in Interstitial Cystitis: A Proposed Biopsy Classification System

Benjamin E. Leiby, J. Richard Landis, Kathleen J. Propert, John E. Tomaszewski

The Journal of Urology > 2007 > 177 > 1 > 142-148

We identified morphologically distinct subgroups in interstitial cystitis using cluster analysis and investigated the associations between cluster membership and urinary symptoms.Of 637 patients enrolled in the Interstitial Cystitis Data Base Study 203 (32%) provided bladder biopsies at baseline screening, representing the focus of this analysis. A cluster analysis algorithm implemented in SAS® PROC...

article

Prospective evaluation of candidate urine and cell markers in patients with interstitial cystitis enrolled in a randomized clinical trial of Bacillus Calmette Guerin (BCG)

Susan Keay, Jay E. Reeder, Kristopher Koch, Chen-Ou Zhang, more

World Journal of Urology > 2007 > 25 > 5 > 499-504

We measured candidate urine biomarkers and bladder cell DNA cytometry in interstitial cystitis (IC) patients randomized to receive intravesical Bacillus Calmette Guerin (BCG) or placebo in a multicenter trial. Participants received 6 weekly instillations and were followed for 34 weeks. Urine was collected at baseline, prior to fourth treatment, and at study end. Antiproliferative factor (APF) activity...

article

How Does the Pre-Massage and Post-Massage 2-Glass Test Compare to the Meares-Stamey 4-Glass Test in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome?

J. Curtis Nickel, Daniel Shoskes, Yanlin Wang, Richard B. Alexander, more

The Journal of Urology > 2006 > 176 > 1 > 119-124

The Meares-Stamey 4-glass test is the standard method of assessing inflammation and the presence of bacteria in the lower urinary tract in men presenting with the chronic prostatitis syndrome. However, most urologists do not use it in daily practice because of the time and difficulty in performing it, as well as the additional expense. We evaluated a simpler test, the 2-glass pre-massage and post-massage...

article

Prostate-specific antigen test in diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome

Robert B. Nadler, Mary McNaughton Collins, Kathleen J. Propert, Stephen D. Mikolajczyk, more

Urology > 2006 > 67 > 2 > 337-342

To determine whether prostate-specific antigen (PSA), the percent free PSA, or free PSA isoforms may be used as diagnostic markers for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS; National Institutes of Health category IIIa and IIIb). We evaluated 421 patients enrolled in the Chronic Prostatitis Cohort Study and 112 age-matched controls. Subjects were stratified by the number of white...

article

GRANULOMATOUS PROSTATITIS LINKED TO HLA-DRB1*1501

RICHARD B. ALEXANDER, DEAN L. MANN, ANDREW A. BORKOWSKI, MARCELO FERNANDEZ-VINA, more

The Journal of Urology > 2004 > 171 > 6 Part 1 > 2326-2329

Granulomatous prostatitis is characterized by a pattern of granulomatous inflammation in the prostate. In most cases the etiology is unknown. Based on the hypothesis that granulomatous prostatitis may be an autoimmune disease we performed intermediate and selective high resolution typing of HLA-DR in a group of patients with the disease and compared the frequency of class II HLA phenotypes to that...

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Search results for: Kathleen J. Propert

The Effect of Skin Pigmentation on the Accuracy of Pulse Oximetry in Infants with Hypoxemia

Association Between Depression and Condom Use Differs by Sexual Behavior Group in Patients with HIV

Is self‐reported adherence associated with clinical outcomes in women treated with anticholinergic medication for overactive bladder?

Urinary incontinence and disability in community‐dwelling women: A cross‐sectional study

Validation of a self‐administered instrument to measure adherence to anticholinergic drugs in women with overactive bladder

Estimating the efficacy of an interstitial cystitis/painful bladder syndrome medication in a randomized trial with both non‐adherence and loss to follow‐up

Omega‐3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers

Construct validity of an instrument to measure neuropathic pain in women with bladder pain syndrome

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

Early Termination of a Trial of Mycophenolate Mofetil for Treatment of Interstitial Cystitis/Painful Bladder Syndrome: Lessons Learned

Analysis of B cell subsets following pancreatic islet cell transplantation in a patient with type 1 diabetes by cytometric fingerprinting

Effect of Amitriptyline on Symptoms in Treatment Naïve Patients With Interstitial Cystitis/Painful Bladder Syndrome

800 CATASTROPHIZING AND SPOUSAL RESPONSES IN MEN SUFFERING FROM CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME (CP/CPPS)

Muscle Tenderness in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: The Chronic Prostatitis Cohort Study

Sexual Function is a Determinant of Poor Quality of Life for Women With Treatment Refractory Interstitial Cystitis

Discovery of Morphological Subgroups That Correlate With Severity of Symptoms in Interstitial Cystitis: A Proposed Biopsy Classification System

Prospective evaluation of candidate urine and cell markers in patients with interstitial cystitis enrolled in a randomized clinical trial of Bacillus Calmette Guerin (BCG)

How Does the Pre-Massage and Post-Massage 2-Glass Test Compare to the Meares-Stamey 4-Glass Test in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome?

Prostate-specific antigen test in diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome

GRANULOMATOUS PROSTATITIS LINKED TO HLA-DRB1*1501

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