Search results for: Ralph Tölg

Items from 1 to 20 out of 25 results

article

Efficacy of drug‐coated balloon angioplasty in early versus late occurring drug‐eluting stent restenosis: A pooled analysis from the randomized ISAR DESIRE 3 and DESIRE 4 trials

Tobias Koch, Salvatore Cassese, Erion Xhepa, Katharina Mayer, more

Catheterization and Cardiovascular Interventions > 96 > 5 > 1008 - 1015

Background Whether there exist differences concerning clinical outcomes between patients presenting with early versus late DES‐ISR undergoing treatment with drug‐coated balloons (DCB) remains a scientific knowledge gap. Methods This is a pooled analysis including patients with DES‐ISR assigned to treatment with DCB in the setting of the ISAR DESIRE 3 and 4 trials. Clinical outcomes were evaluated...

article

Safety and clinical performance of a drug eluting absorbable metal scaffold in the treatment of subjects with de novo lesions in native coronary arteries: Pooled 12‐month outcomes of BIOSOLVE‐II and BIOSOLVE‐III

Michael Haude, Hüseyin Ince, Stephan Kische, Alexandre Abizaid, more

Catheterization and Cardiovascular Interventions > 92 > 7 > E502 - E511

Objectives Based on outcomes of the BIOSOLVE‐II study, a novel second generation drug‐eluting absorbable metal scaffold gained CE‐mark in 2016. The BIOSOLVE‐III study aimed to confirm these outcomes and to obtain additional 12‐month angiographic data. Background Bioresorbable scaffolds are intended to overcome possible long‐term effects of permanent stents such as chronic vessel wall inflammation,...

article

Dual Antithrombotic Therapy with Clopidogrel and Novel Oral Anticoagulants in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Real-world Study

Julia Kebernik, Martin Borlich, Ralph Tölg, Mohamed El-Mawardy, more

Cardiology and Therapy > 2018 > 7 > 1 > 79-87

Introduction For patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI), proper antithrombotic therapy is equivocal. Current guidelines recommend triple therapy, which carries a high risk of bleeding. Recent large trials suggest that dual therapy (DT) with novel oral anticoagulant (NOAC) plus P2Y₁₂ inhibitor can be an appropriate alternative, but real-world data...

article

In vivo serial invasive imaging of the second-generation drug-eluting absorbable metal scaffold (Magmaris — DREAMS 2G) in de novo coronary lesions: Insights from the BIOSOLVE-II First-In-Man Trial

Hector M. Garcia-Garcia, Michael Haude, Kayode Kuku, Alexandre Hideo-Kajita, more

International Journal of Cardiology > 2018 > 255 > C > 22-28

Bioresorbable scaffolds may confer clinical benefit in long-term studies; early mechanistic studies using intravascular imaging have provided insightful information about the immediate and mid-term local serial effects of BRS on the coronary vessel wall.We assessed baseline, 6- and 12-month imaging data of the drug-eluting absorbable metal scaffold (DREAMS 2G).The international, first-in-man BIOSOLVE-II...

article

CRT-600.06 Implantation Technique in Magmaris Second-generation Drug-eluting Absorbable Metal Scaffold in Patients with Denovo Coronary Artery Lesions: Optical Coherence Tomography Analysis

Yuichi Ozaki, Hector M. Garcia-Garcia, Alexandre Hideo Kajita, Kayode O. Kuku, more

JACC: Cardiovascular Interventions > 2018 > 11 > 4(S) > S43

article

The fate of incomplete scaffold apposition of everolimus-eluting bioresorble scaffolds: A serial optical coherence tomography analysis

Takao Sato, Ralph Tölg, Mohamed El-Mawardy, Dmitriy S. Sulimov, more

Journal of Cardiology > 2017 > 70 > 5 > 454-460

Incomplete stent apposition (ISA) can be divided into acute and late forms. Late ISA may be due to persistent ISA or late-acquired ISA (LAISA). This study evaluated the natural course of ISA after bioresorbable vascular scaffold (BRS) implantation using optical coherence tomography (OCT).Thirty-two patients (45 BRS) were assessed immediately after BRS implantation and 1 year thereafter using OCT....

article

Neointimal Modification With Scoring Balloon and Efficacy of Drug-Coated Balloon Therapy in Patients With Restenosis in Drug-Eluting Coronary Stents

Sebastian Kufner, Michael Joner, Simon Schneider, Ralph Tölg, more

JACC: Cardiovascular Interventions > 2017 > 10 > 13 > 1332-1340

The aim of this study was to compare neointimal modification with scoring balloon pre-dilation before drug-coated balloon (DCB) versus DCB standard therapy in patients presenting with drug-eluting stent (DES) restenosis.DCB angioplasty for the treatment of coronary drug-eluting stent restenosis has demonstrated encouraging results. The efficacy of DCB treatment relies on rapid initial drug transfer...

article

Effect of strut distribution on neointimal coverage of everolimus-eluting bioresorbable scaffolds: an optical coherence tomography study

Takao Sato, John Jose, Abdelhakim Allai, Mohamed El-Mawardy, more

Journal of Thrombosis and Thrombolysis > 2017 > 44 > 2 > 161-168

The thick struts of bioresorbable vascular scaffolds (BRS) are associated with changes in wall shear stress and contribute to neointimal proliferation. We aimed to evaluate the relationship between the BRS strut distribution and the neointimal proliferation. 50 lesions underwent optical coherence tomography, 12 months after BRS implantation. Scaffold area and neointimal thickness were evaluated in...

article

Relationship between peri-strut low intensity areas and vascular healing response after everolimus-eluting bioresorbable scaffold implantation: An optical coherence tomography study

Takao Sato, John Jose, Mohamed El-Mawardy, Dmitriy S. Sulimov, more

Journal of Cardiology > 2017 > 69 > 4 > 606-612

Peri-strut low intensity areas (PLIA) surrounding metallic coronary stent struts on optical coherence tomography (OCT) images have been histologically related to delayed healing and inflammation, and have been associated with neointimal proliferation. The relationship between PLIA and vascular healing response after bioresorbable scaffold (BRS) implantation remains unclear.This study includes 38 consecutive...

article

Predictors of acute scaffold recoil after implantation of the everolimus-eluting bioresorbable scaffold: an optical coherence tomography assessment in native coronary arteries

Takao Sato, John Jose, Mohamed El-Mawardy, Dmitriy S. Sulimov, more

The International Journal of Cardiovascular Imaging > 2017 > 33 > 2 > 145-152

This study investigated the predictors of acute recoil after implantation of everolimus-eluting BRS based on optical coherence tomography (OCT). Thirty-nine patients (56 scaffolds) were enrolled. Acute absolute recoil by quantitative coronary angiography was defined as the difference between the mean diameter of the last inflated balloon (X) and the mean lumen diameter of BRS immediately after balloon...

article

Neointimal response to everolimus-eluting bioresorbable scaffolds implanted at bifurcating coronary segments: insights from optical coherence tomography

Takao Sato, John Jose, Mohamed El-Mawardy, Dmitriy S. Sulimov, more

The International Journal of Cardiovascular Imaging > 2017 > 33 > 2 > 169-175

Heterogeneity of neointimal thickness is observed after drug-eluting stents implantation in bifurcation lesions (BL). We evaluated the vascular response of everolimus-eluting bioresorbable scaffold (BRS) struts deployed at BL using optical coherence tomography (OCT). 50 patients (64 scaffolds) underwent follow-up OCT after BRS implantation. Cross-sectional areas of each BL with a side branch more...

article

Neointimal coverage of overlapping everolimus-eluting bioresorbable scaffolds: An optical coherence tomography study in native coronary arteries

Takao Sato, John Jose, Mohamed El-Mawardy, Dmitriy S. Sulimov, more

International Journal of Cardiology > 2016 > 221 > C > 243-245

article

Three-year efficacy and safety of new- versus early-generation drug-eluting stents for unprotected left main coronary artery disease insights from the ISAR-LEFT MAIN and ISAR-LEFT MAIN 2 trials

Salvatore Cassese, Sebastian Kufner, Erion Xhepa, Robert A. Byrne, more

Clinical Research in Cardiology > 2016 > 105 > 7 > 575-584

Background In percutaneous coronary intervention (PCI) patients new-generation drug-eluting stent (DES) has reduced adverse events in comparison to early-generation DES. The aim of the current study was to investigate the long-term clinical efficacy and safety of new-generation DES versus early-generation DES for PCI of unprotected left main coronary artery (uLMCA) disease. Methods The patient-level...

article

Outcome of percutaneous coronary intervention with drug-eluting stents in unprotected left main versus non-left main native coronary artery disease: results from the prospective multicenter German DES.DE registry

I. Akin, C. Naber, G. Sabin, M. Hochadel, more

Clinical Research in Cardiology > 2013 > 102 > 9 > 679-686

Background Unprotected left main coronary artery (ULMCA) disease is considered an indication for surgical revascularization. However, refined percutaneous coronary intervention (PCI) technology and modern drug-eluting stents (DES) render the ULMCA a target for interventional treatment. Methods and results Between October 2005 and September 2009, 374 patients receiving DES in ULMCA and 18,678 patients...

article

Twelve-month results of a Paclitaxel Releasing Balloon in Patients Presenting with In-stent Restenosis First-in-Man (PEPPER) trial

Christoph Hehrlein, Ulrich Dietz, Jacek Kubica, Erik Jørgensen, more

Cardiovascular Revascularization Medicine > 2012 > 13 > 5 > 260-264

Coronary in-stent restenosis (ISR) continues to be a therapeutic challenge especially after drug eluting stent (DES) implantation. We studied patients with ISR to investigate safety and efficacy of a novel drug coated balloon (DCB) incorporating paclitaxel into a microcrystalline structure by applying the inert excipient butyryltri-n-hexyl citrate (BTHC) in a prospective First-in-Man trial.Eighty-one...

article

No Evidence of “Obesity Paradox” After Treatment With Drug-Eluting Stents in a Routine Clinical Practice

Ibrahim Akin, Ralph Tölg, Matthias Hochadel, Martin W. Bergmann, more

JACC: Cardiovascular Interventions > 2012 > 5 > 2 > 162-169

The aim of this study was to compare clinical outcomes among unselected patients stratified in categories of body mass index, who underwent percutaneous coronary intervention (PCI) with either sirolimus-eluting or paclitaxel-eluting stents.Overweight and obesity are often considered risk factors for cardiovascular events. However, recent studies have associated obesity with better outcomes after PCI...

article

Cardiogoniometry as a diagnostic tool in patients with acute coronary syndromes: results of the CGM@ACS trial

Ralph Tölg, Uwe Zeymer, Ralf Birkemeyer, Rainer Wessely, more

Clinical Research in Cardiology > 2012 > 101 > 9 > 727-736

Background Cardiogoniometry (CGM) is a novel electrocardiac method utilising computer-assisted three-dimensional information on cardiac potentials. Objective To investigate the potential of CGM in discriminating non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and relevant coronary stenosis upon hospital admission by prospectively comparing its sensitivity, specificity and accuracy against...

article

Anatomic and Procedural Predictors of Paravalvular Aortic Regurgitation After Implantation of the Medtronic CoreValve Bioprosthesis

Mohammad A. Sherif, Mohamed Abdel-Wahab, Björn Stöcker, Volker Geist, more

Journal of the American College of Cardiology > 2010 > 56 > 20 > 1623-1629

The purpose of this study was to determine the predictors of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI).TAVI has been associated with a high rate of paravalvular regurgitation, usually mild. Nevertheless, moderate to severe regurgitations still occur and may have negative clinical consequences.Fifty patients with severe aortic stenosis were recruited and underwent...

article

Early hemodynamic and neurohormonal response after transcatheter aortic valve implantation

Mohammad A. Sherif, Mohamed Abdel-Wahab, Omar Awad, Volker Geist, more

American Heart Journal > 2010 > 160 > 5 > 862-869

The conventional surgical aortic bioprostheses used for treatment of aortic stenosis (AS) are inherently stenotic in nature. The more favorable mechanical profile of the Medtronic CoreValve bioprosthesis may translate into a better hemodynamic and neurohormonal response.The early hemodynamic and neurohormonal responses of 56 patients who underwent successful transcatheter aortic valve implantation...

article

Simvastatin and Ezetimibe in Addition to Nonpharmacological Risk Factor Modification for Achieving New Low-Density Lipoprotein Cholesterol Targets

Branislav Liska, Ahmed A. Khattab, Lutz Herrmann, Mohamed Abdel-Wahab, more

Herz > 2008 > 33 > 5 > 362-367

Background: Though guidelines emphasize low-density lipoprotein cholesterol (LDL-C) lowering as an essential strategy for cardiovascular risk reduction, achieving target levels may be difficult. Patients and Methods: The authors conducted a prospective, controlled, open-label trial examining the effectiveness and safety of high-dose fluvastatin or a standard dosage of simvastatin plus ezetimibe,...

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Search results for: Ralph Tölg

Efficacy of drug‐coated balloon angioplasty in early versus late occurring drug‐eluting stent restenosis: A pooled analysis from the randomized ISAR DESIRE 3 and DESIRE 4 trials

Safety and clinical performance of a drug eluting absorbable metal scaffold in the treatment of subjects with de novo lesions in native coronary arteries: Pooled 12‐month outcomes of BIOSOLVE‐II and BIOSOLVE‐III

Dual Antithrombotic Therapy with Clopidogrel and Novel Oral Anticoagulants in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Real-world Study

In vivo serial invasive imaging of the second-generation drug-eluting absorbable metal scaffold (Magmaris — DREAMS 2G) in de novo coronary lesions: Insights from the BIOSOLVE-II First-In-Man Trial

CRT-600.06 Implantation Technique in Magmaris Second-generation Drug-eluting Absorbable Metal Scaffold in Patients with Denovo Coronary Artery Lesions: Optical Coherence Tomography Analysis

The fate of incomplete scaffold apposition of everolimus-eluting bioresorble scaffolds: A serial optical coherence tomography analysis

Neointimal Modification With Scoring Balloon and Efficacy of Drug-Coated Balloon Therapy in Patients With Restenosis in Drug-Eluting Coronary Stents

Effect of strut distribution on neointimal coverage of everolimus-eluting bioresorbable scaffolds: an optical coherence tomography study

Relationship between peri-strut low intensity areas and vascular healing response after everolimus-eluting bioresorbable scaffold implantation: An optical coherence tomography study

Predictors of acute scaffold recoil after implantation of the everolimus-eluting bioresorbable scaffold: an optical coherence tomography assessment in native coronary arteries

Neointimal response to everolimus-eluting bioresorbable scaffolds implanted at bifurcating coronary segments: insights from optical coherence tomography

Neointimal coverage of overlapping everolimus-eluting bioresorbable scaffolds: An optical coherence tomography study in native coronary arteries

Three-year efficacy and safety of new- versus early-generation drug-eluting stents for unprotected left main coronary artery disease insights from the ISAR-LEFT MAIN and ISAR-LEFT MAIN 2 trials

Outcome of percutaneous coronary intervention with drug-eluting stents in unprotected left main versus non-left main native coronary artery disease: results from the prospective multicenter German DES.DE registry

Twelve-month results of a Paclitaxel Releasing Balloon in Patients Presenting with In-stent Restenosis First-in-Man (PEPPER) trial

No Evidence of “Obesity Paradox” After Treatment With Drug-Eluting Stents in a Routine Clinical Practice

Cardiogoniometry as a diagnostic tool in patients with acute coronary syndromes: results of the CGM@ACS trial

Anatomic and Procedural Predictors of Paravalvular Aortic Regurgitation After Implantation of the Medtronic CoreValve Bioprosthesis

Early hemodynamic and neurohormonal response after transcatheter aortic valve implantation

Simvastatin and Ezetimibe in Addition to Nonpharmacological Risk Factor Modification for Achieving New Low-Density Lipoprotein Cholesterol Targets

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