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Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies that mainly target muscle nicotinic acetylcholine receptor (AChR) and cause loss of functional AChRs in the neuromuscular junction. Despite extensive knowledge from studies on MG and its major autoantigen, the aetiology of the disease remains unclear, thus rendering therapeutic options unable to target the causative agent....
Myasthenia gravis (MG) is caused by autoantibodies to the acetylcholine receptor (AChR). Experiments with fetal (α 2 βγδ) and adult (α 2 βεδ) AChR and with recombinant subunit dimers showed that some monoclonal antibodies (mAbs) against the main immunogenic region (MIR), located on the α-subunit of the AChR, bind better to fetal AChR and to αγ subunit dimer than to adult AChR and αε...
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