Search results for: Takashi Komori

Items from 1 to 20 out of 64 results

article

Adverse childhood experiences exacerbate peripheral symptoms of autism spectrum disorder in adults

Kazuki Okumura, Tsutomu Takeda, Takashi Komori, Michihiro Toritsuka, more

Psychiatry and Clinical Neurosciences > 78 > 10 > 580 - 587

Aim Adverse childhood experiences are potentially traumatic events with long‐lasting effects on the health and well‐being of patients with autism spectrum disorder (ASD). It is important to clarify which types of long‐lasting autism‐related symptoms are influenced by childhood experiences to design future intervention studies. However, few studies have examined the association between childhood experiences...

article

Altered properties of amyloidogenic prion protein in genetic Creutzfeldt–Jakob disease with PRNP V180I mutation in response to pentosan polysulfate

Masahiro Shijo, Motoi Yoshimura, Tsuyoshi Omae, Go Hashimoto, more

Brain Pathology > 33 > 5 > n/a - n/a

Genetic Creutzfeldt–Jakob disease (gCJD) with V180I prion protein gene (PRNP) mutation shows weaker prion protein (PrP) deposition histologically compared with sporadic CJD, and it is more difficult to detect protease‐resistant prion protein in immunoblotting. However, we previously reported the autopsy case of a patient with V180I gCJD who was treated with pentosan polysulfate sodium (PPS); this...

article

A difficult‐to‐diagnose anaplastic meningioma with spinal cord dissemination and cytokeratin positivity

Shuhei Morita, Ayako Horiba, Kenta Masui, Koji Yamaguchi, more

Pathology International > 73 > 7 > 323 - 326

article

Recurrent high‐grade astrocytoma with somatic mosaicism of isocitrate dehydrogenase gene mutation

Kenta Masui, Hiromi Onizuka, Masayuki Nitta, Yoshihiro Muragaki, more

Pathology International > 73 > 3 > 144 - 146

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Distribution of amyloid‐β precursor protein‐immunoreactive axons differs according to the severity of cerebral ischemia in autopsy brains

Erika Seki, Takashi Komori, Nobutaka Arai

Neuropathology > 42 > 4 > 269 - 273

Amyloid‐β precursor protein (APP) immunohistochemistry has been used to detect axonal injury in forensic neuropathology. However, axonal injury caused by cerebral ischemia has not been investigated by APP immunohistochemistry in detail. In particular, it is unknown if there is a correlation between the prognosis of cerebral ischemia and the distribution of axonal injury detected by APP immunohistochemistry...

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Tufted astrocyte‐like glia in two autopsy cases of multiple system atrophy: Is it a concomitant neurodegenerative disorder with multiple system atrophy and progressive supranuclear palsy?

Taku Homma, Yoko Mochizuki, Shinsuke Tobisawa, Takashi Komori, more

Neuropathology > 42 > 1 > 74 - 81

Tufted astrocytes are one of the core histopathological features of progressive supranuclear palsy (PSP). To our knowledge, only three cases of multiple system atrophy (MSA) with PSP pathology have been reported. Here, we report two autopsy cases of MSA associated with the appearance of tufted astrocyte‐like glia (TuALG). Clinically, the patients' symptoms were atypical of MSA; one showed vertical...

article

Implementation of evidence‐based intervention for suicidal patients admitted to the emergency department: Implications from our real‐world experience of assertive case management

Kazuya Okamura, Takashi Komori, Mai Sugimoto, Yoshitaka Kawashima, more

Psychiatry and Clinical Neurosciences > 75 > 3 > 108 - 109

article

cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading

David N. Louis, Pieter Wesseling, Kenneth Aldape, Daniel J. Brat, more

Brain Pathology > 30 > 4 > 844 - 856

cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid progress in molecular insights into these neoplasms. For Round 2 of its deliberations, cIMPACT‐NOW Working Committee 3 was reconstituted and convened...

article

Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors

Shiro Matsubara, Morinobu Seki, Shigeaki Suzuki, Takashi Komori, more

Journal for ImmunoTherapy of Cancer > 2019 > 7 > 1 > 1-7

Background Programmed cell death 1 inhibitors have revolutionized therapy for cancer by their outstanding effectiveness. However, they may cause adverse effects, among which inflammatory myopathy is one of the most disabling. To elucidate its mechanism, we analysed muscle biopsies and compared them with other inflammatory myopathies. Methods Muscle biopsies from three patients with inflammatory...

article

Intradural radicular arteriovenous fistula that mimics dural arteriovenous fistula: report of three cases

Keisuke Takai, Takashi Komori, Hiroki Kurita, Kensuke Kawai, more

Neuroradiology > 2019 > 61 > 10 > 1203-1208

We herein present three cases of a rare type of spinal AVF, an intradural radicular AVF, which mimicked a dural AVF. A 65-year-old male presented with congestive myelopathy. On angiography, right vertebral angiogram (VAG) showed a suspected dural AVF; however, left VAG showed the same intradural dilated vein fed by the anterior spinal artery (ASA). Intraoperative and histological results suggested...

article

Brainstem astroblastoma with MN1 translocation

Sun Ah Shin, Bokyung Ahn, Seung‐Ki Kim, Hyoung Jin Kang, more

Neuropathology > 38 > 6 > 631 - 637

Astroblastoma is a rare glial neoplasm that occurs mostly in the cerebral hemisphere of children, adolescents and young adults. Although astroblastic perivascular pseudorosettes are unique histopathology of this neoplasm, diagnosis is usually challenging. Recently, it was discovered that the meningioma 1 gene (MN1)‐altered pediatric central nervous system high‐grade neuroepithelial tumors are actually...

article

Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

Kohei Fukuoka, Yonehiro Kanemura, Tomoko Shofuda, Shintaro Fukushima, more

Acta Neuropathologica Communications > 2018 > 6 > 1 > 1-18

Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas have distinct molecular profiles and are likely to be different diseases. The presence of C11orf95-RELA fusion genes in a subset of supratentorial ependymomas (ST-EPN) indicated the existence of molecular subgroups. However, the pathogenesis of RELA fusion-negative ependymomas remains...

article

A Rare Case of Malignant Craniopharyngioma Reactive to Adjunctive Stereotactic Radiotherapy and Chemotherapy: Case Report and Literature Review

Shunsuke Nomura, Yasuo Aihara, Kosaku Amano, Seiichiro Eguchi, more

World Neurosurgery > 2018 > 117 > C > 332-338

Malignant craniopharyngioma or anaplastic craniopharyngioma was first reported in 1987 by Akachi and colleagues. It has malignant clinical and histological features, remarkably rapid progression, atypical pathology like squamous cell carcinoma, and a poor prognosis. To date, 17 cases of malignant craniopharyngioma have been reported, most of which were secondary malignant tumors. In classic benign...

article

A surgical strategy for lower grade gliomas using intraoperative molecular diagnosis

Shunichi Koriyama, Masayuki Nitta, Tatsuya Kobayashi, Yoshihiro Muragaki, more

Brain Tumor Pathology > 2018 > 35 > 3 > 159-167

Lower grade gliomas are both treated and diagnosed via surgical resection. Maximum tumor resection is currently the standard of care; however, this risks the loss of brain function. Glioma can be genetically subdivided into three different types, based on isocitrate dehydrogenase (IDH) mutation status and the presence of 1p/19q codeletion, which have radically different prognoses and responses to...

article

Altered gene expression in lymphoblastoid cell lines after subculture

Michihiro Toritsuka, Manabu Makinodan, Takahira Yamauchi, Yasunori Yamashita, more

In Vitro Cellular & Developmental Biology - Animal > 2018 > 54 > 7 > 523-527

Lymphoblastoid cell lines (LCLs) are nearly immortalized B lymphocytes that are used as long-lasting supply of human cells for studies on gene expression analyses. However, studies on the stability of the cellular features of LCLs are scarce. To address this issue, we measured gene expression in LCLs with different passage numbers and observed that gene expression substantially changed within 10 passages...

article

Transient Focal Magnetic Resonance Imaging Abnormalities After Status Epilepticus Showed 11C-Methionine Uptake with Positron Emission Tomography in a Patient with Cerebral Cavernous Malformation

Taichi Ishiguro, Masayuki Nitta, Takashi Komori, Takashi Maruyama, more

World Neurosurgery > 2018 > 114 > C > 43-46

Transient focal magnetic resonance imaging (MRI) abnormalities after status epilepticus (SE) are rarely seen in patients with benign brain tumors, and the underlying mechanism is still unknown. We report a rare case of cerebral cavernous malformation with transient focal MRI abnormalities around the tumor and accumulation of 11C-methionine on positron emission tomography (PET) after SE. These findings...

article

Gliosarcoma arising from oligodendroglioma, IDH mutant and 1p/19q codeleted

Takayuki Yasuda, Masayuki Nitta, Takashi Komori, Tatsuya Kobayashi, more

Neuropathology > 38 > 1 > 41 - 46

Herein, we present a rare case of gliosarcoma arising from oligodendroglioma, isocitrate dehydrogenase (IDH) mutant and 1p/19q codeleted. A 36‐year‐old man presented with a non‐enhanced calcified abnormal lesion on the right frontal lobe. The patient underwent subtotal surgical resection, PAV chemotherapy (procarbazine, nimustine (ACNU) and vincristine), and fractionated radiotherapy with 50 Gy. The...

article

Comprehensive genetic characterization of rosette‐forming glioneuronal tumors: independent component analysis by tissue microdissection

Yohei Kitamura, Takashi Komori, Makoto Shibuya, Kentaro Ohara, more

Brain Pathology > 28 > 1 > 87 - 93

A rosette‐forming glioneuronal tumor (RGNT) is a rare mixed neuronal‐glial tumor characterized by biphasic architecture of glial and neurocytic components. The number of reports of genetic analyses of RGNTs is few. Additionally, the genetic background of the unique biphasic pathological characteristics of such mixed neuronal‐glial tumors remains unclear. To clarify the genetic background of RGNTs,...

article

Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation

Keisuke Takai, Shota Tanaka, Takashi Sota, Akitake Mukasa, more

World Neurosurgery > 2017 > 108 > C > 991.e13-991.e16

In 2016, the World Health Organization updated its classification of tumors, adding genetic profiles to the conventional histopathologic typing.The authors present herein the first case of a 44-year-old female with isocitrate dehydrogenase–mutant World Health Organization grade II diffuse spinal astrocytoma diagnosed on the basis of both histopathologic and genetic findings.The present case underscores...

article

Pathology of oligodendroglia: An overview

Takashi Komori

Neuropathology > 37 > 5 > 465 - 474

Oligodendroglia are cells responsible for creating myelin sheaths for axons in the CNS. However, pathologies of oligodendroglia other than demyelination are not well understood due to the lack of adequate methods of characterizing pathological conditions affecting oligodendroglia in human tissue. This review discusses three major topics with the aim of clarifying some of the controversies in the study...

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INFONA - science communication portal

Search results for: Takashi Komori

Adverse childhood experiences exacerbate peripheral symptoms of autism spectrum disorder in adults

Altered properties of amyloidogenic prion protein in genetic Creutzfeldt–Jakob disease with PRNP V180I mutation in response to pentosan polysulfate

A difficult‐to‐diagnose anaplastic meningioma with spinal cord dissemination and cytokeratin positivity

Recurrent high‐grade astrocytoma with somatic mosaicism of isocitrate dehydrogenase gene mutation

Distribution of amyloid‐β precursor protein‐immunoreactive axons differs according to the severity of cerebral ischemia in autopsy brains

Tufted astrocyte‐like glia in two autopsy cases of multiple system atrophy: Is it a concomitant neurodegenerative disorder with multiple system atrophy and progressive supranuclear palsy?

Implementation of evidence‐based intervention for suicidal patients admitted to the emergency department: Implications from our real‐world experience of assertive case management

cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading

Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors

Intradural radicular arteriovenous fistula that mimics dural arteriovenous fistula: report of three cases

Brainstem astroblastoma with MN1 translocation

Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

A Rare Case of Malignant Craniopharyngioma Reactive to Adjunctive Stereotactic Radiotherapy and Chemotherapy: Case Report and Literature Review

A surgical strategy for lower grade gliomas using intraoperative molecular diagnosis

Altered gene expression in lymphoblastoid cell lines after subculture

Transient Focal Magnetic Resonance Imaging Abnormalities After Status Epilepticus Showed 11C-Methionine Uptake with Positron Emission Tomography in a Patient with Cerebral Cavernous Malformation

Gliosarcoma arising from oligodendroglioma, IDH mutant and 1p/19q codeleted

Comprehensive genetic characterization of rosette‐forming glioneuronal tumors: independent component analysis by tissue microdissection

Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation

Pathology of oligodendroglia: An overview

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