Search results for: Ewa Malecka‐Panas

Items from 1 to 20 out of 64 results

article

Scoring system assessing mucosal visibility of upper gastrointestinal tract: The POLPREP scale

Marcin Romańczyk, Bartosz Ostrowski, Katarzyna Kozłowska‐Petriczko, Katarzyna M. Pawlak, more

Journal of Gastroenterology and Hepatology > 37 > 1 > 164 - 168

Background and Aim The proper visibility of mucosa during esophagogastroduodenoscopy (EGD) is crucial for the detection of early upper gastrointestinal tract lesions. In contrast to colonoscopy, no validated scoring system for the assessment of upper gastrointestinal mucosal cleanliness has been developed so far. The aim of the study was to create and validate standardized grading system (POLPREP)...

article

Brain‐derived neurotrophic factor is elevated in the blood serum of Crohn's disease patients, but is not influenced by anti‐TNF‐α treatment—A pilot study

Marcin Sochal, Ewa Małecka‐Panas, Agata Gabryelska, Jakub Fichna, more

Neurogastroenterology & Motility > 33 > 6 > n/a - n/a

Background Brain‐derived neurotrophic factor (BDNF) is associated with depression, pain, or sleep disorders, factors that are thought to be involved in the pathogenesis and clinical course of Crohn's disease (CD). Therefore, the study aimed at assessing the BDNF serum level in patients with CD and evaluates the effect of anti‐TNF‐α therapy on the BDNF level and its impact on sleep, mood, and pain...

article

Genome‐wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

Chiara Corradi, Manuel Gentiluomo, László Gajdán, Giulia Martina Cavestro, more

International Journal of Cancer > 148 > 11 > 2779 - 2788

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer‐related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability...

article

Novel selective agonist of GPR18, PSB‐KK‐1415 exerts potent anti‐inflammatory and anti‐nociceptive activities in animal models of intestinal inflammation and inflammatory pain

Adam Fabisiak, Natalia Fabisiak, Anna Mokrowiecka, Ewa Malecka‐Panas, more

Neurogastroenterology & Motility > 33 > 3 > n/a - n/a

Background GPR18 is a recently deorphanized receptor which was reported to act with several endogenous cannabinoid ligands. Here, we aimed to describe the role of GPR18 in intestinal inflammation and inflammatory pain. Methods The anti‐inflammatory activity of selective GPR18 agonist, PSB‐KK‐1415, and antagonist, PSB‐CB5, was characterized in semi‐chronic and chronic mouse models of colitis induced...

article

Genome‐wide association study identifies an early onset pancreatic cancer risk locus

Daniele Campa, Manuel Gentiluomo, Ofure Obazee, Alba Ballerini, more

International Journal of Cancer > 147 > 8 > 2065 - 2074

Early onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore, we performed a genome‐wide association study (GWAS) to identify novel genetic variants specific for patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) at younger ages. In the first phase, conducted on 821 cases with age of onset...

article

Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis

Frank Ulrich Weiss, Nico Hesselbarth, Andrea Párniczky, Dora Mosztbacher, more

Pancreatology > 2018 > 18 > 5 > 477-481

Acute pancreatitis (AP) is one of the most common gastrointestinal disorders often requiring hospitalization. Frequent aetiologies are gallstones and alcohol abuse. In contrast to chronic pancreatitis (CP) few robust genetic associations have been described. Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP...

article

Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation

Daniele Campa, Manuela Pastore, Gabriele Capurso, Thilo Hackert, more

International Journal of Cancer > 142 > 2 > 290 - 296

Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a five‐year survival of less than 6%. Chronic pancreatitis (CP), an inflammatory process in of the pancreas, is a strong risk factor for PDAC. Several genetic polymorphisms have been discovered as susceptibility loci for both CP and PDAC. Since CP and PDAC share a consistent number of epidemiologic risk factors, the aim of this...

article

Prognostic role of Hedgehog signaling pathway markers in pancreatic carcinogenesis

Katarzyna Winter, Janusz Strzelczyk, Monika Dzieniecka, Małgorzata Wągrowska-Danilewicz, more

Pancreatology > 2017 > 17 > 3(S) > S51

article

Evaluation of insulin-like growth factor (IGF-1) and retinol binding protein (RBP-4) levels in patients with newly diagnosed pancreatic adenocarcinoma (PDAC)

Barbara Wlodarczyk, Anita Gasiorowska, Anna Borkowska, Ewa Malecka-Panas

Pancreatology > 2017 > 17 > 4 > 623-628

The elevation of insulin-like growth factor 1 (IGF-1) and adipokine retinol-binding protein 4 (RBP-4) is known to be associated with the risk of many cancers. The aim of this study was to evaluate the serum concentrations of IGF-1 and RBP-4 in patients with PDAC and chronic pancreatitis (CP).The study included 43 patients with PDAC, 39 patients with CP and 10 controls. The concentrations of IGF-1...

article

Do pancreatic adenocarcinomas and neuroendocrine neoplasms share genetic susceptibility a PANDoRA study

Federico Canzian, Gabriele Capurso, Angelo Andriulli, John P. Neoptolemos, more

Pancreatology > 2017 > 17 > 3(S) > S32

article

Rare BRCA2 K3326X increases susceptibility to sporadic pancreatic ductal adenocarcinoma: A PANDoRA study

Ofure Obazee, Gabriele Carpurso, Angelo Adriulli, Pavel Soucek, more

Pancreatology > 2017 > 17 > 3(S) > S31-S32

article

Expression profiles of cancer stem cell markers: CD133, CD44, Musashi-1 and EpCAM in the cardiac mucosa—Barrett’s esophagus—early esophageal adenocarcinoma—advanced esophageal adenocarcinoma sequence

Anna Mokrowiecka, Lothar Veits, Christina Falkeis, Jacek Musial, more

Pathology - Research and Practice > 2017 > 213 > 3 > 205-209

Barrett's esophagus (BE), which develops as a result of gastroesophageal reflux disease, is a preneoplastic condition for esophageal adenocarcinoma (EAC). A new hypothesis suggests that cancer is a disease of stem cells, however, their expression and pathways in BE − EAC sequence are not fully elucidated yet.We used a panel of putative cancer stem cells markers to identify stem cells in consecutive...

article

Serum levels of insulin-like growth factor 1 (IGF-1) and insulin like growth factor binding protein 2 (IGFBP-2) in patients with pancreatic adenocarcinoma (PDAC)

Barbara Wlodarczyk, Anna Borkowska, Ewa Malecka-Panas, Anita Gasiorowska

Pancreatology > 2016 > 16 > 3(S1) > S90

article

Sa1477 Evaluation of Insulin-Like Growth Factor (IGF-1) and Retinol Binding Protein (RBP-4) Concentration Levels in Patients With Newly Diagnosed Pancreatic Adenocarcinoma (PDAC)

Barbara Wlodarczyk, Anna Borkowska, Ewa Malecka-Panas, Anita Gasiorowska

Gastroenterology > 2016 > 150 > 4(S1) > S326

article

Sa1469 Differential Expression of Hedgehog Signaling Pathway in Pancreatic Ductal Adenocarcinoma (PDAC) and Chronic Pancreatitis (CP)

Katarzyna Winter, Janusz Strzelczyk, Monika Dzieniecka, Malgorzata Wagrowska-Danilewicz, more

Gastroenterology > 2016 > 150 > 4(S1) > S324

article

The Association Between Adiposity and Survival in Patients with Colorectal Cancer

Lukasz Durko, Ewa Malecka-Panas

Current Nutrition Reports > 2016 > 5 > 1 > 48-53

Multiple studies confirm the impact of obesity on high incidence of colorectal cancer (CRC). There is a common perception that adiposity and related metabolic dysfunctions result in worse prognosis and decreased survival among patients with a CRC diagnosis. Several epidemiologic studies confirm this observation, however the results are not always consistent, probably due to different techniques used...

article

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility

Daniele Campa, Cosmeri Rizzato, Rachael Stolzenberg‐Solomon, Paola Pacetti, more

International Journal of Cancer > 137 > 9 > 2175 - 2183

A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT–CLPTM1L gene region on chromosome 5p15.33. Because this region is characterized by low linkage disequilibrium, we sought to identify whether additional single nucleotide polymorphisms (SNPs) could be related to pancreatic cancer risk, independently of rs401681. We...

article

Expression of Hedgehog signaling pathway in pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP)

Katarzyna Winter, Janusz Strzelczyk, Monika Dzieniecka, Malgorzata Wagrowska-Danilewicz, more

Pancreatology > 2015 > 15 > 3 Supplement > S88

article

Clinical significance of hyaluronic acid and soluble fractalkine in pancreatic adenocarcinoma

Anna Kozak, Anita Gasiorowska, Anna Borkowska, Leszek Czupryniak, more

Pancreatology > 2015 > 15 > 3 Supplement > S21

article

Evaluation of insulin-like growth factor (IGF-1) and retinol binding protein (RBP-4) concentration levels in patients with newly diagnosed pancreatic adenocarcinoma

Barbara Wlodarczyk, Anna Borkowska, Ewa Malecka-Panas, Anita Gasiorowska

Pancreatology > 2015 > 15 > 3 Supplement > S92

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INFONA - science communication portal

Search results for: Ewa Malecka‐Panas

Scoring system assessing mucosal visibility of upper gastrointestinal tract: The POLPREP scale

Brain‐derived neurotrophic factor is elevated in the blood serum of Crohn's disease patients, but is not influenced by anti‐TNF‐α treatment—A pilot study

Genome‐wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

Novel selective agonist of GPR18, PSB‐KK‐1415 exerts potent anti‐inflammatory and anti‐nociceptive activities in animal models of intestinal inflammation and inflammatory pain

Genome‐wide association study identifies an early onset pancreatic cancer risk locus

Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis

Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation

Prognostic role of Hedgehog signaling pathway markers in pancreatic carcinogenesis

Evaluation of insulin-like growth factor (IGF-1) and retinol binding protein (RBP-4) levels in patients with newly diagnosed pancreatic adenocarcinoma (PDAC)

Do pancreatic adenocarcinomas and neuroendocrine neoplasms share genetic susceptibility a PANDoRA study

Rare BRCA2 K3326X increases susceptibility to sporadic pancreatic ductal adenocarcinoma: A PANDoRA study

Expression profiles of cancer stem cell markers: CD133, CD44, Musashi-1 and EpCAM in the cardiac mucosa—Barrett’s esophagus—early esophageal adenocarcinoma—advanced esophageal adenocarcinoma sequence

Serum levels of insulin-like growth factor 1 (IGF-1) and insulin like growth factor binding protein 2 (IGFBP-2) in patients with pancreatic adenocarcinoma (PDAC)

Sa1477 Evaluation of Insulin-Like Growth Factor (IGF-1) and Retinol Binding Protein (RBP-4) Concentration Levels in Patients With Newly Diagnosed Pancreatic Adenocarcinoma (PDAC)

Sa1469 Differential Expression of Hedgehog Signaling Pathway in Pancreatic Ductal Adenocarcinoma (PDAC) and Chronic Pancreatitis (CP)

The Association Between Adiposity and Survival in Patients with Colorectal Cancer

TERT gene harbors multiple variants associated with pancreatic cancer susceptibility

Expression of Hedgehog signaling pathway in pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP)

Clinical significance of hyaluronic acid and soluble fractalkine in pancreatic adenocarcinoma

Evaluation of insulin-like growth factor (IGF-1) and retinol binding protein (RBP-4) concentration levels in patients with newly diagnosed pancreatic adenocarcinoma

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