Search results for: Mitsuru Seki

Items from 1 to 20 out of 23 results

article

Hemorrhagic duodenal ulcer as a rare complication prior to antiplatelet therapy for Kawasaki disease

Yusuke Hashimoto, Hideki Kumagai, Yuko Okada, Mitsuru Seki, more

Pediatrics International > 65 > 1 > n/a - n/a

article

Continuous cyclosporine a infusion in patients with severe Kawasaki disease

Mitsuru Seki, Takaomi Minami, Shun Suzuki, Sadahiro Furui, more

Pediatrics International > 64 > 1 > n/a - n/a

Background The efficacy and safety of continuous intravenous infusion of cyclosporine A (CICsA) in patients with intravenous immunoglobulin‐resistant Kawasaki disease are unclear. Methods Between 2010 and 2020, 83 patients with Kawasaki disease that was not responsive to intravenous immunoglobulin (total dose ≥ 4 g/kg) were enrolled. All patients were started on CICsA (3 mg/kg/day) and switched...

article

A case of Kawasaki disease complicated by acute disseminated encephalitis

Sadahiro Furui, Mitsuru Seki, Takaomi Minami, Masahide Goto, more

Pediatrics International > 62 > 7 > 872 - 873

article

Occurrence of Kawasaki disease after simultaneous immunization

Daisuke Matsubara, Takaomi Minami, Mitsuru Seki, Daisuke Tamura, more

Pediatrics International > 61 > 11 > 1171 - 1173

article

Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey in Japan

Hiroshi Masuda, Tohru Kobayashi, Akira Hachiya, Yasutaka Nakashima, more

The Journal of Pediatrics > 2018 > 195 > C > 115-120.e3

To assess the safety and efficacy of infliximab (IFX) for the treatment of patients with Kawasaki disease (KD).This was a nationwide survey of 274 Japanese institutions exploring how IFX was used to treat patients with KD. The patients' sex, age, treatment course, pre- and post-IFX therapy blood test results, coronary artery lesions (CALs), and adverse events (AEs) were evaluated.We analyzed 434 patients...

article

A New Z Score Curve of the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population

Tohru Kobayashi, Shigeto Fuse, Naoko Sakamoto, Masashi Mikami, more

Journal of the American Society of Echocardiography > 2016 > 29 > 8 > 794-801.e29

Several coronary artery Z score models have been developed. However, a Z score model derived by the lambda-mu-sigma (LMS) method has not been established.Echocardiographic measurements of the proximal right coronary artery, left main coronary artery, proximal left anterior descending coronary artery, and proximal left circumflex artery were prospectively collected in 3,851 healthy children ≤18 years...

article

Ventricular fibrogenesis activity assessed by serum levels of procollagen type III N-terminal amino peptide during the staged Fontan procedure

Masaya Sugimoto, Hirofumi Saiki, Akiko Tamai, Mitsuru Seki, more

The Journal of Thoracic and Cardiovascular Surgery > 2016 > 151 > 6 > 1518-1526

We tested the hypotheses that volume overload and cyanosis observed in the pre-Fontan single ventricular circulation are associated with increased ventricular fibrogenesis, that the Fontan procedure helps to reduce fibrogenesis, and that persistently increased fibrogenesis in the Fontan ventricle is associated with ventricular diastolic dysfunction.Levels of serum amino-terminal procollagen type III,...

article

Mechanism of aortic root dilation and cardiovascular function in tetralogy of Fallot

Mitsuru Seki, Seiko Kuwata, Clara Kurishima, Ryo Nakagawa, more

Pediatrics International > 58 > 5 > 323 - 330

The aortic root dilation in tetralogy of Fallot (TOF) is a long‐term clinical problem, because a severely dilated aorta can lead to aortic regurgitation, dissection, or rupture, which can be fatal, necessitating surgical intervention. The details of the mechanism of aortic root dilation, however, are unclear. We have shown that aortic stiffness is increased in patients with repaired TOF, and may mirror...

article

MICRORNA-21 UPREGULATION CONTRIBUTES TO RIGHT VENTRICULAR FAILURE THROUGH PHOSPHATASE AND TENSIN HOMOLOG-DRIVEN FIBROSIS

Jeffery Powers, Mitsuru Seki, John Holten, Anthony Poidomani, more

Journal of the American College of Cardiology > 2016 > 67 > 13(S) > 1397

article

CLASS I HISTONE DEACETYLASE INHIBITION REDUCES SUSTAINED ATRIAL FIBRILLATION AND REMODELING IN DOGS

Mitsuru Seki, Jeffery Powers, Jianhe Huang, Ryan LaCanna, more

Journal of the American College of Cardiology > 2016 > 67 > 13(S) > 671

article

Periostin Cre-mediated Hypoxia-inducible Transfroming Growth Factor-β Receptor Deletion in Pulmonary Artery Prevents Pulmonary Arterial Hypertension in Mice

Mitsuru Seki, Norimichi Koitabashi, Hirokazu Arakawa, Masahiko Kurabayashi

Journal of Cardiac Failure > 2014 > 20 > 10 Supplement > S145

article

Fibroblast-specific TGFβ Receptor Inhibition Promotes Smooth Muscle Proliferation in Coronary Artery of Pressure-overloaded Mouse Heart

Norimichi Koitabashi, Masaru Obokata, Mitsuru Seki, Simon Conway, more

Journal of Cardiac Failure > 2014 > 20 > 10 Supplement > S150

article

Reply

Hideaki Senzaki, Ryo Inuzuka, Mitsuru Seki, Masaya Sugimoto, more

The Annals of Thoracic Surgery > 2014 > 97 > 5 > 1854-1855

article

Progressive aortic dilation and aortic stiffness in children with repaired tetralogy of Fallot

Mitsuru Seki, Clara Kurishima, Hirofumi Saiki, Satoshi Masutani, more

Heart and Vessels > 2014 > 29 > 1 > 83-87

Progressive aortic dilation occurs in patients with tetralogy of Fallot (TOF), possibly due to abnormal histopathology of the aortic media that weakens the aortic wall. This medial histopathology may be reflected as aortic stiffness, which in turn may predict progressive aortic dilation. To test this theory, we studied the relationship between aortic wall stiffness, measured by pulse wave velocity...

article

Pulmonary Arterial Wall Stiffness and Its Impact on Right Ventricular Afterload in Patients With Repaired Tetralogy of Fallot

Ryo Inuzuka, Mitsuru Seki, Masaya Sugimoto, Hirofumi Saiki, more

The Annals of Thoracic Surgery > 2013 > 96 > 4 > 1435-1441

Recent histologic studies involving patients with tetralogy of Fallot (TOF) have revealed a reduction in normal elastic fibers in the pulmonary trunk. Such histologic changes may significantly alter the mechanical properties of the arterial wall and may thereby augment the pulsatile afterload on the right ventricle (RV) and propagate RV dilation and dysfunction.We studied 29 patients with repaired...

article

Efficacy of Intravenous Immunoglobulin Combined with Prednisolone Following Resistance to Initial Intravenous Immunoglobulin Treatment of Acute Kawasaki Disease

Tohru Kobayashi, Tomio Kobayashi, Akihiro Morikawa, Kentaro Ikeda, more

The Journal of Pediatrics > 2013 > 163 > 2 > 521-526.e1

To determine the most effective first-line rescue therapy for intravenous immunoglobulin (IVIG) nonresponders, using IVIG, prednisolone, or both, to prevent coronary artery abnormalities (CAAs).We retrospectively reviewed the clinical records of 359 consecutive patients with Kawasaki disease who failed to respond to initial IVIG.CAAs up to 1 month after treatment were less common in the IVIG+prednisolone...

article

Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial

Tohru Kobayashi, Tsutomu Saji, Tetsuya Otani, Kazuo Takeuchi, more

The Lancet > 2012 > 379 > 9826 > 1613-1620

Evidence indicates that corticosteroid therapy might be beneficial for the primary treatment of severe Kawasaki disease. We assessed whether addition of prednisolone to intravenous immunoglobulin with aspirin would reduce the incidence of coronary artery abnormalities in patients with severe Kawasaki disease. We did a multicentre, prospective, randomised, open-label, blinded-endpoints trial at...

article

Findings in the Pulmonary Vascular Bed in the Remote Phase After Kawasaki Disease

Masaya Sugimoto, Hirotaka Ishido, Mitsuru Seki, Satoshi Masutani, more

The American Journal of Cardiology > 2012 > 109 > 8 > 1219-1222

Kawasaki disease (KD) is a form of systemic vasculitis that causes chronic changes in arterial walls, including pulmonary arteries. The aim of this study was to test the hypothesis that pulmonary arterial wall properties and hemodynamics are abnormal after the resolution of KD. Pulmonary arterial input impedance was measured during cardiac catheterization (4.8 ± 4.5 years after disease onset) in 47...

article

Noninvasive assessment of left ventricular contractility in pediatric patients using the maximum rate of pressure rise in peripheral arteries

Hidenori Kawasaki, Mitsuru Seki, Hirofumi Saiki, Satoshi Masutani, more

Heart and Vessels > 2012 > 27 > 4 > 384-390

The maximum rate of left ventricular pressure rise (LV dp/dt _max) is a good indicator of ventricular contractility. However, its measurement requires invasive cardiac catheterization. By applying the relationship between the ratio of aorta (Ao) dp/dt _max to LV dp/dt _max and the mean artery pressure (MAP), we tested the possible noninvasive estimation of LV dp/dt _max by the maximum rate of pressure...

article

Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome

Mitsuru Seki, Hirokazu Kimura, Akio Mori, Akira Shimada, more

Pediatrics International > 52 > 4 > e196 - e199

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INFONA - science communication portal

Search results for: Mitsuru Seki

Hemorrhagic duodenal ulcer as a rare complication prior to antiplatelet therapy for Kawasaki disease

Continuous cyclosporine a infusion in patients with severe Kawasaki disease

A case of Kawasaki disease complicated by acute disseminated encephalitis

Occurrence of Kawasaki disease after simultaneous immunization

Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey in Japan

A New Z Score Curve of the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population

Ventricular fibrogenesis activity assessed by serum levels of procollagen type III N-terminal amino peptide during the staged Fontan procedure

Mechanism of aortic root dilation and cardiovascular function in tetralogy of Fallot

MICRORNA-21 UPREGULATION CONTRIBUTES TO RIGHT VENTRICULAR FAILURE THROUGH PHOSPHATASE AND TENSIN HOMOLOG-DRIVEN FIBROSIS

CLASS I HISTONE DEACETYLASE INHIBITION REDUCES SUSTAINED ATRIAL FIBRILLATION AND REMODELING IN DOGS

Periostin Cre-mediated Hypoxia-inducible Transfroming Growth Factor-β Receptor Deletion in Pulmonary Artery Prevents Pulmonary Arterial Hypertension in Mice

Fibroblast-specific TGFβ Receptor Inhibition Promotes Smooth Muscle Proliferation in Coronary Artery of Pressure-overloaded Mouse Heart

Reply

Progressive aortic dilation and aortic stiffness in children with repaired tetralogy of Fallot

Pulmonary Arterial Wall Stiffness and Its Impact on Right Ventricular Afterload in Patients With Repaired Tetralogy of Fallot

Efficacy of Intravenous Immunoglobulin Combined with Prednisolone Following Resistance to Initial Intravenous Immunoglobulin Treatment of Acute Kawasaki Disease

Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial

Findings in the Pulmonary Vascular Bed in the Remote Phase After Kawasaki Disease

Noninvasive assessment of left ventricular contractility in pediatric patients using the maximum rate of pressure rise in peripheral arteries

Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome

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