Search results for: Jiahong Xu

Items from 1 to 20 out of 21 results

article

AbDPP: Target‐oriented antibody design with pretraining and prior biological structure knowledge

Chenglei Yu, Xiangtian Lin, Yuxuan Cheng, Jiahong Xu, more

Proteins: Structure, Function, and Bioinformatics > 92 > 10 > 1147 - 1160

Antibodies represent a crucial class of complex protein therapeutics and are essential in the treatment of a wide range of human diseases. Traditional antibody discovery methods, such as hybridoma and phage display technologies, suffer from limitations including inefficiency and a restricted exploration of the immense space of potential antibodies. To overcome these limitations, we propose a novel...

article

Deep learning‐based optimal tracking control of flow front position in an injection molding machine

Jiahong Xu, Zhigang Ren, Shengli Xie, Yalin Wang, more

Optimal Control Applications and Methods > 44 > 3 > 1376 - 1393

The product quality of injection‐molded plastic is closely related to the injection flow velocity of molten plastics. In this article, an optimal tracking control problem for the injection flow front position arising in the filling process in the injection molding machine (IMM) is considered, and an intelligent real‐time optimal control method based on deep neural networks (DNNs) is developed for...

article

The dephosphorylation of FADD at S191 induces an excessive expansion of TCRαβ⁺ IELs in the intestinal mucosa

Xuerui Zhang, Banghui Zhu, Lin Li, Jiahong Xu, more

Immunology > 167 > 2 > 233 - 246

Intestinal intraepithelial lymphocytes (IELs) play a crucial role in host defence against pathogens in the intestinal mucosa. The development of intestinal IELs is distinct from peripheral T lymphocytes and remains elusive. Fas‐associated protein with death domain (FADD) is important for T cell development in the thymus. Here we describe a novel function of FADD in the IEL development. FADD (S191A),...

article

Correction to: Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

Yihua Bei, Tianzhao Xu, Dongchao Lv, Pujiao Yu, more

Basic Research in Cardiology > 2019 > 114 > 6 > 1-1

The original version of this article unfortunately contained a mistake.

article

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

Yihua Bei, Li-Long Pan, Qiulian Zhou, Cuimei Zhao, more

BMC Medicine > 2019 > 17 > 1 > 1-20

Background Cathelicidins are a major group of natural antimicrobial peptides which play essential roles in regulating host defense and immunity. In addition to the antimicrobial and immunomodulatory activities, recent studies have reported the involvement of cathelicidins in cardiovascular diseases by regulating inflammatory response and microvascular dysfunction. However, the role of cathelicidins...

article

Serum Extracellular Vesicles Retard H9C2 Cell Senescence by Suppressing miR-34a Expression

Yang Liu, Zhuyuan Liu, Yuan Xie, Cuimei Zhao, more

Journal of Cardiovascular Translational Research > 2019 > 12 > 1 > 45-50

Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced cardiomyocytes senescence remains elusive. In this study, we found that human serum EVs inhibited DOX-induced senescence in H9C2 cells, which was abolished by miR-34a...

article

The Impact of Cell Phone Support on Psychosocial Outcomes for Youth Living with HIV Nonadherent to Antiretroviral Therapy

Caitlin S. Sayegh, Karen K. MacDonell, Leslie F. Clark, Nadia L. Dowshen, more

AIDS and Behavior > 2018 > 22 > 10 > 3357-3362

Mobile health interventions to promote adherence to antiretroviral therapy among adolescents and young adults living with HIV represent a promising strategy. This pilot study (N = 37) evaluated the psychosocial impacts of an efficacious adherence intervention, cell phone support (CPS). Participants receiving CPS reported significant decreases in perceived stress, depression, and illicit substance...

article

Synthesis and larvicidal activity of 1,3,4-oxadiazole derivatives containing a 3-chloropyridin-2-yl-1H-pyrazole scaffold

Yanyan Wang, Xiumian Lu, Jun Shi, Jiahong Xu, more

Monatshefte für Chemie - Chemical Monthly > 2018 > 149 > 3 > 611-623

A new series of 1,3,4-oxadiazole derivatives with a 3-chloropyridin-2-yl-1H-pyrazole moiety was designed, synthesized, and characterized. The results of bioassay against Helicoverpa armigera and Plutella xylostella indicated that some of the synthesized compounds showed remarkable larvicidal activity. In particular, the LC₅₀ values of the most active compounds against P. xylostella were 46.5, 23.9,...

article

Synthesis and insecticidal activity of diacylhydrazine derivatives containing a 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole scaffold

Yanyan Wang, Fangzhou Xu, Gang Yu, Jun Shi, more

Chemistry Central Journal > 2017 > 11 > 1 > 1-11

Background The diacylhydrazine derivatives have attracted considerable attention in recently years due to their simple structure, low toxicity, and high insecticidal selectivity. As well as 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole is an important scaffold in many insecticidal molecules. In an effort to discover new molecules with good insecticidal activity, a series of diacylhydrazine derivatives...

article

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

Yihua Bei, Tianzhao Xu, Dongchao Lv, Pujiao Yu, more

Basic Research in Cardiology > 2017 > 112 > 4 > 1-15

Extracellular vesicles (EVs) serve an important function as mediators of intercellular communication. Exercise is protective for the heart, although the signaling mechanisms that mediate this cardioprotection have not been fully elucidated. Here using nano-flow cytometry, we found a rapid increase in plasma EVs in human subjects undergoing exercise stress testing. We subsequently identified that serum...

article

Profiles of Risk Among HIV-Infected Youth in Clinic Settings

M. Isabel Fernández, Heather C. Huszti, Patrick A. Wilson, Shoshana Kahana, more

AIDS and Behavior > 2015 > 19 > 5 > 918-930

Despite the rising number of new HIV infections among youth, few tailored interventions for youth living with HIV (YLH) have been developed and rigorously tested. Developing tailored interventions necessitates identifying different profiles of YLH and understanding how risk and protective factors cluster together. Obtaining this critical information requires accessing a sufficiently large sample of...

article

Immune function of peripheral T cells in patients with venous thromboembolism or coronary artery atherosclerosis

Lin Zhou, Haoming Song, Wenjun Xu, Jiahong Xu, more

Revista Portuguesa de Cardiologia (English Edition) > 2014 > 33 > 6 > 339-344

Recent studies have shown that the major risk factors for arterial thrombotic diseases are closely associated with venous thromboembolism (VTE). This study aimed to investigate the expression of CD3, CD4 and CD8 in T lymphocytes, the CD4/CD8 ratio and high-sensitivity C-reactive protein (hs-CRP) levels in patients with VTE, coronary artery atherosclerosis (CAA) and healthy subjects.A total of 82 healthy...

article

Development and Implementation of Health and Wellness CBT for Individuals With Depression and HIV

Beth D. Kennard, Larry T. Brown, Linda Hawkins, Andrea Risi, more

Cognitive and Behavioral Practice > 2014 > 21 > 2 > 237-246

Rates of depression are reported to be between 22% to 33% in adults with HIV, which is double that of the general population. Depression negatively affects treatment adherence and health outcomes of those with medical illnesses. Further, it has been shown in adults that reducing depression may improve both adherence and health outcomes. To address the issues of depression and nonadherence, Health...

article

Substance abuse treatment for HIV infected young people: An open pilot trial

Christianne Esposito-Smythers, Larry K. Brown, Jennifer Wolff, Jiahong Xu, more

Journal of Substance Abuse Treatment > 2014 > 46 > 2 > 244-250

The purpose of this study was to test an integrated cognitive behavioral and contingency management (CBT/CM) intervention for young people living with HIV (YPLH) with an alcohol and/or cannabis use disorder in an open pilot trial. Seventeen participants (ages 18–24) were recruited from three HIV community clinics. Assessments were completed at pre-and post-treatment as well as 3month follow-up. Eighty...

article

Factors Affecting Linkage to Care and Engagement in Care for Newly Diagnosed HIV-Positive Adolescents Within Fifteen Adolescent Medicine Clinics in the United States

Morgan M. Philbin, Amanda E. Tanner, Anna DuVal, Jonathan M. Ellen, more

AIDS and Behavior > 2014 > 18 > 8 > 1501-1510

Early linkage to care and engagement in care are critical for initiation of medical interventions. However, over 50 % of newly diagnosed persons do not receive HIV-related care within 6 months of diagnosis. We evaluated a linkage to care and engagement in care initiative for HIV-positive adolescents in 15 U.S.-based clinics. Structural and client-level factors (e.g. demographic and behavioral characteristics,...

article

The effect of PPARG gene polymorphisms on the risk of coronary heart disease: a meta-analysis

Wenjun Xu, Jiahong Xu, Bing Sun, Haibin Chen, more

Molecular Biology Reports > 2013 > 40 > 2 > 875-884

The peroxisome proliferator-activated receptor-γ (PPARG) is a member of the nuclear hormone receptor superfamily that has attracted considerable attention as a candidate gene for coronary heart disease (CHD) based on its function as a key factor involved in the regulation of lipid and glucose metabolism. In the past decade, a number of case–control studies have been carried out to investigate the...

article

Risk Perceptions After Human Papillomavirus Vaccination in HIV-Infected Adolescents and Young Adult Women

Jessica A. Kahn, Jiahong Xu, Gregory D. Zimet, Nancy Liu, more

Journal of Adolescent Health > 2012 > 50 > 5 > 464-470

To examine risk perceptions (perceived risk of human papillomavirus [HPV], perceived risk of other sexually transmitted infections [STIs], and need for safer sexual behaviors) and to determine factors associated with these risk perceptions after HPV vaccination. Data were collected at the baseline visit of an HPV-6, −11, −16, −18 vaccine clinical trial in 16–23-year-old HIV-infected young women...

article

Circulating microRNAs: novel biomarkers for cardiovascular diseases

Jiahong Xu, Jiangmin Zhao, Graham Evan, Chunyang Xiao, more

Journal of Molecular Medicine > 2012 > 90 > 8 > 865-875

MicroRNAs (miRNAs) are a novel class of small, non-coding, single-stranded RNAs that negatively regulate gene expression via translational inhibition or mRNA degradation followed by protein synthesis repression. Many miRNAs are expressed in a tissue- and/or cell-specific manner and their expression patterns are reflective of underlying patho-physiologic processes. miRNAs can be detected in serum or...

article

β₂‐ but not β₁‐adrenoceptor activation modulates intracellular oxygen availability

Jun Li, Biao Yan, Zhaoxia Huo, Ying Liu, more

The Journal of Physiology > 588 > 16 > 2987 - 2998

β‐Adrenoceptors (β‐ARs) play a critical role in the regulation of cardiovascular function. Intracellular oxygen homeostasis is crucial for the survival of cardiomyocytes. However, it is still unclear whether β‐AR activation can modulate intracellular oxygen. Here we used mitochondrial and cytosolic target Renilla luciferase to detect intracellular oxygen concentration. Pharmacological experiments...

article

Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: Clinical implications

Alexander Chi, Zhongxing Liao, Nam P. Nguyen, Jiahong Xu, more

Radiotherapy and Oncology > 2010 > 94 > 1 > 1-11

To analyze the patterns of failure, the toxicity profile, and the factors influencing efficacy of stereotactic body radiation (SBRT) for early-stage non-small-cell lung cancer (NSCLC).A search was based on PubMed electronic databases. All searches were conducted in May, 2009.The local control ranged from 80% to 100% in most studies with adequate isocentric or peripheral biologically effective dose...

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INFONA - science communication portal

Search results for: Jiahong Xu

AbDPP: Target‐oriented antibody design with pretraining and prior biological structure knowledge

Deep learning‐based optimal tracking control of flow front position in an injection molding machine

The dephosphorylation of FADD at S191 induces an excessive expansion of TCRαβ⁺ IELs in the intestinal mucosa

Correction to: Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

Serum Extracellular Vesicles Retard H9C2 Cell Senescence by Suppressing miR-34a Expression

The Impact of Cell Phone Support on Psychosocial Outcomes for Youth Living with HIV Nonadherent to Antiretroviral Therapy

Synthesis and larvicidal activity of 1,3,4-oxadiazole derivatives containing a 3-chloropyridin-2-yl-1H-pyrazole scaffold

Synthesis and insecticidal activity of diacylhydrazine derivatives containing a 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole scaffold

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

Profiles of Risk Among HIV-Infected Youth in Clinic Settings

Immune function of peripheral T cells in patients with venous thromboembolism or coronary artery atherosclerosis

Development and Implementation of Health and Wellness CBT for Individuals With Depression and HIV

Substance abuse treatment for HIV infected young people: An open pilot trial

Factors Affecting Linkage to Care and Engagement in Care for Newly Diagnosed HIV-Positive Adolescents Within Fifteen Adolescent Medicine Clinics in the United States

The effect of PPARG gene polymorphisms on the risk of coronary heart disease: a meta-analysis

Risk Perceptions After Human Papillomavirus Vaccination in HIV-Infected Adolescents and Young Adult Women

Circulating microRNAs: novel biomarkers for cardiovascular diseases

β₂‐ but not β₁‐adrenoceptor activation modulates intracellular oxygen availability

Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: Clinical implications

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