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In article number 1902393, Charles G. Knutson, Roger D. Kamm, and co‐workers use microvascular networks self‐assembled from human cells within microfluid devices to directly measure trans‐capillary solute flux. Physiological fluid flow through the cell junctions, passive diffusion across the cell membrane, and active vesicular transport, recapitulate the in vivo mode and magnitude of transport for...
In vitro prediction of physiologically relevant transport of therapeutic molecules across the microcirculation represents an intriguing opportunity to predict efficacy in human populations. On‐chip microvascular networks (MVNs) show physiologically relevant values of molecular permeability, yet like most systems, they lack an important contribution to transport: the ever‐present fluid convection through...
A cysteine was introduced into the FG-loop (P187C) of CYP51 from Mycobacterium tuberculosis (MT) for selective labeling with BODIPY and fluorescence energy transfer (FRET) analysis. Förster radius for the BODIPY–heme pair was calculated assuming that the distance between the heme and Cys187 in solution corresponds to that in the crystal structure of ligand free MTCYP51. Interaction of MTCYP51 with...
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