Search results for: Rosa G. Liberman

Items from 1 to 11 out of 11 results

article

BEAMS Lab at MIT: Status report

Rosa G. Liberman, Paul L. Skipper, Steven R. Tannenbaum

Nuclear Inst. and Methods in Physics Research, B > 2010 > 268 > 7-8 > 887-890

The Biological Engineering Accelerator Mass Spectrometry (BEAMS) Lab at the Massachusetts Institute of Technology is a facility dedicated to incorporating AMS into life sciences research. As such, it is focused exclusively on radiocarbon and tritium AMS and makes use of a particularly compact instrument of a size compatible with most laboratory space. Recent developments at the BEAMS Lab were aimed...

article

Integration of Continuous-Flow Accelerator Mass Spectrometry with Chromatography and Mass-Selective Detection

Jimmy Flarakos, Rosa G. Liberman, Steven R. Tannenbaum, Paul L. Skipper

Analytical Chemistry > 2008 > 80 > 13 > 5079 - 5085

article

Monitoring in Vivo Metabolism and Elimination of the Endogenous DNA Adduct, M ₁ dG {3-(2-Deoxy-β- d - erythro -pentofuranosyl)pyrimido[1,2-α]purin-10(3 H )-one}, by Accelerator Mass Spectrometry ^†

Charles G. Knutson, Paul L. Skipper, Rosa G. Liberman, Steven R. Tannenbaum, more

Chemical Research in Toxicology > 2008 > 21 > 6 > 1290 - 1294

article

Analysis of DNA Adducts Formed in Vivo in Rats and Mice from 1,2-Dibromoethane, 1,2-Dichloroethane, Dibromomethane, and Dichloromethane Using HPLC/Accelerator Mass Spectrometry and Relevance to Risk Estimates ^†

Kengo Watanabe, Rosa G. Liberman, Paul L. Skipper, Steven R. Tannenbaum, more

Chemical Research in Toxicology > 2007 > 20 > 11 > 1594 - 1600

article

BEAMS Lab: Novel approaches to finding a balance between throughput and sensitivity

Rosa G. Liberman, Paul L. Skipper, Chandra Prakash, Christopher L. Shaffer, more

Nuclear Inst. and Methods in Physics Research, B > 2007 > 259 > 1 > 773-778

Development of ¹⁴ C AMS has long pursued the twin goals of maximizing both sensitivity and precision in the interest, among others, of optimizing radiocarbon dating. Application of AMS to biomedical research is less constrained with respect to sensitivity requirements, but more demanding of high throughput. This work presents some technical and conceptual developments in sample processing...

article

A gas-multiplication telescope detector for low-energy ions

Rosa G. Liberman, Ulrich J. Becker, Paul L. Skipper

Nuclear Inst. and Methods in Physics Research, A > 2006 > 565 > 2 > 686-690

A new detector has been designed and built for the accelerator mass spectrometry (AMS) system at the MIT BEAMS Laboratory. This gas ionization detector uses the common segmented-anode design to measure energy loss in two sectors. It differs from existing designs in having wire grid anodes rather than flat plates in order to permit gas multiplication of the signals induced by drift electrons from initial...

article

DNA Adduct Formation by 2,6-Dimethyl-, 3,5-Dimethyl-, and 3-Ethylaniline in Vivo in Mice

Paul L. Skipper, Laura J. Trudel, Thomas W. Kensler, John D. Groopman, more

Chemical Research in Toxicology > 2006 > 19 > 8 > 1086 - 1090

article

Quantification of DNA strand breaks and abasic sites by oxime derivatization and accelerator mass spectrometry: Application to γ-radiation and peroxynitrite

Xinfeng Zhou, Rosa G. Liberman, Paul L. Skipper, Yelena Margolin, more

Analytical Biochemistry > 2005 > 343 > 1 > 84-92

We report a highly sensitive method to quantify abasic sites and deoxyribose oxidation products arising in damaged DNA. The method exploits the reaction of aldehyde- and ketone-containing deoxyribose oxidation products and abasic sites with [ ¹⁴ C]methoxyamine to form stable oxime derivatives, as originally described by Talpaert-Borle and Liuzzi [Reaction of apurinic/apyrimidinic sites with...

article

Bringing AMS into the bioanalytical chemistry lab

Paul L Skipper, Barbara J Hughey, Rosa G Liberman, Man Ho Choi, more

Nuclear Inst. and Methods in Physics Research, B > 2004 > 223-224 > Complete > 740-744

Three different interfaces for coupling an accelerator mass spectrometer to other bioanalytical instruments were constructed and tested. All three produce gaseous samples – CO ₂ or H ₂ – and connect to a gas-fed AMS ion source. The gas chromatograph interface functions as an on-line reactor for analysis of ¹⁴ C-labeled compounds. The laser-induced combustion interface provides...

article

The NSI biomedical AMS system at MIT: current status

Rosa G Liberman, Barbara J Hughey, Paul L Skipper, John S Wishnok, more

Nuclear Inst. and Methods in Physics Research, B > 2004 > 223-224 > Complete > 82-86

A compact, low-energy AMS system designed for detection of ¹⁴ C and ³ H in bioanalytical chemistry applications has been completed and has undergone initial performance evaluation. The instrument is equipped with a gas-fed ion source that accepts a flow of carrier gas from any of several interfaces that convert sample carbon and hydrogen in real time to CO ₂ and H ₂ ...

article

An Interface for Direct Analysis of ¹⁴ C in Nonvolatile Samples by Accelerator Mass Spectrometry

Rosa G. Liberman, Steven R. Tannenbaum, Barbara J. Hughey, Ruth E. Shefer, more

Analytical Chemistry > 2004 > 76 > 2 > 328 - 334

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Keywords

ACCELERATOR MASS SPECTROMETRY (4)
BIOMEDICAL AMS (3)
CARBON-14 (2)
GAS-FED ION SOURCE (2)
TRITIUM (2)
14C LABELED COMPOUNDS (1)
14C LABELING (1)
ABASIC SITES (1)
BIOLOGICAL AMS (1)
BIOMEDICAL SAMPLES (1)
BOUNCING WIEN FILTER ELECTRIC FIELD (1)
CONTROL SYSTEM (1)
DNA DAMAGE (1)
DRUG PHARMACOKINETICS (1)
HIGH THROUGHPUT (1)
HIGH THROUGHPUT LASER-INDUCED COMBUSTION INTERFACE (1)
INTERFACE (1)
METABOLITE PROFILING (1)
METHOXYAMINE (1)
OXIME DERIVATIZATION (1)
SEGMENTED ANODE IONIZATION CHAMBER (1)
STRAND BREAKS (1)
TRITIUM AMS (1)
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Elsevier (6)
ACS (5)

INFONA - science communication portal

Search results for: Rosa G. Liberman

BEAMS Lab at MIT: Status report

Integration of Continuous-Flow Accelerator Mass Spectrometry with Chromatography and Mass-Selective Detection

Monitoring in Vivo Metabolism and Elimination of the Endogenous DNA Adduct, M ₁ dG {3-(2-Deoxy-β- d - erythro -pentofuranosyl)pyrimido[1,2-α]purin-10(3 H )-one}, by Accelerator Mass Spectrometry ^†

Analysis of DNA Adducts Formed in Vivo in Rats and Mice from 1,2-Dibromoethane, 1,2-Dichloroethane, Dibromomethane, and Dichloromethane Using HPLC/Accelerator Mass Spectrometry and Relevance to Risk Estimates ^†

BEAMS Lab: Novel approaches to finding a balance between throughput and sensitivity

A gas-multiplication telescope detector for low-energy ions

DNA Adduct Formation by 2,6-Dimethyl-, 3,5-Dimethyl-, and 3-Ethylaniline in Vivo in Mice

Quantification of DNA strand breaks and abasic sites by oxime derivatization and accelerator mass spectrometry: Application to γ-radiation and peroxynitrite

Bringing AMS into the bioanalytical chemistry lab

The NSI biomedical AMS system at MIT: current status

An Interface for Direct Analysis of ¹⁴ C in Nonvolatile Samples by Accelerator Mass Spectrometry

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